Expression of the membrane-associated mucin MUC-1 and its relationship with Ki67 in mucoepidermoid carcinoma of the salivary
Background: Salivary gland tumors are rare and with different malignant potential. Immunohistochemistry is useful, especially Ki67, a marker of cell proliferation, for its prognostic information. On the other side, the mucin MUC-1 is overexpressed and loses its exclusively apical membranous localiza...
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| Lenguaje: | Español |
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Facultad de Odontología
2022
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/39610 |
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I10-R335-article-396102022-12-05T14:41:32Z Expression of the membrane-associated mucin MUC-1 and its relationship with Ki67 in mucoepidermoid carcinoma of the salivary Expresión de la mucina asociada a membrana MUC-1/ y su relación con Ki67 en el carcinoma mucoepidermoide de glándulas salivales Gomez Rosso, Maria Araceli salivary tumors mucoepidermoid carcinoma histological grade MUC-1 Ki67 tumores salivales, carcinoma mucoepidermoide, grado histológico, MUC-1, Ki67 Background: Salivary gland tumors are rare and with different malignant potential. Immunohistochemistry is useful, especially Ki67, a marker of cell proliferation, for its prognostic information. On the other side, the mucin MUC-1 is overexpressed and loses its exclusively apical membranous localization and is aberrantly glycosylated in mucoepidermoid carcinoma of salivary glands. In the present work, we investigated the quantitative expression of tumor proliferative index and localization and overexpression of MUC-1 in the mucoepidermoid carcinoma of the human salivary glands, not studied is these organs, to determine their relationship with the histological grade and prognosis. Methods: H/E staining and immunohistochemistry with MUC-1 and Ki67 antibodies was performed on 10 cases. Results: The markings of the mucoepidermoid carcinoma depended on the histological grade; in low- grade tumors with MUC-1 only 10 to 25% of the cells were labeled, in contrast to high- grade tumors, with 75 to 90% labeled cells. They also differed in cell proliferation; in the low-grade tumors was 15% and in high-grade tumors it was greater than 30%. Conclusion: MUC-1 overexpression is significantly higher in high-grade mucoepidermoid carcinoma, as is Ki67 marking, results that are associated with tumor prognosis Objetivo: los tumores de glándulas salivales son raros y con diferente potencial maligno. La inmunohistoquímica es útil, especialmente Ki67, marcador de proliferación celular, para su información pronóstica. Por otro lado, la mucina MUC-1 se sobreexpresa y pierde su localización membranosa exclusivamente apical y además se glicosila de forma aberrante en neoplasias malignas de distintos órganos. En el presente trabajo se investigó la expresión cuantitativa del índice proliferativo tumoral y la localización y sobreexpresión de MUC-1 en el carcinoma mucoepidermoide de glándulas salivales humanas, no estudiadas según el grado histológico y pronóstico de esta neoplasia maligna. Métodos: tinción con H/E e inmunohistoquímica con los anticuerpos MUC-1 y KI67 fueron realizadas en 10 casos. Resultados: las marcaciones inmunohistoquímicas del carcinoma mucoepidermoide dependieron de su grado histológico; en los tumores de bajo grado sólo se marcaron con MUC-1 10 a 25% de las células, a diferencia de los tumores de alto grado, con 75 a 90% de células marcadas. También se diferenciaron en la proliferación celular; en los tumores de bajo grado fue de 15% y en los de alto grado mayor al 30%. Conclusión: la sobreexpresión de MUC-1 es significativamente mayor en el carcinoma mucoepidermoide de alto grado al igual que la marcación con Ki67, resultados que se asocian al pronóstico tumoral Facultad de Odontología 2022-12-05 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/39610 Revista de la Facultad de Odontología; Vol. 32 Núm. 3 (2022): Rev Fac Odont 32(3)-2022-Diciembre; 10-18 2545-7594 0325-1071 spa https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/39610/39642 https://creativecommons.org/licenses/by-nc-sa/4.0 |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-335 |
| container_title_str |
Revista de la Facultad de Odontología |
| language |
Español |
| format |
Artículo revista |
| topic |
salivary tumors mucoepidermoid carcinoma histological grade MUC-1 Ki67 tumores salivales, carcinoma mucoepidermoide, grado histológico, MUC-1, Ki67 |
| spellingShingle |
salivary tumors mucoepidermoid carcinoma histological grade MUC-1 Ki67 tumores salivales, carcinoma mucoepidermoide, grado histológico, MUC-1, Ki67 Gomez Rosso, Maria Araceli Expression of the membrane-associated mucin MUC-1 and its relationship with Ki67 in mucoepidermoid carcinoma of the salivary |
| topic_facet |
salivary tumors mucoepidermoid carcinoma histological grade MUC-1 Ki67 tumores salivales, carcinoma mucoepidermoide, grado histológico, MUC-1, Ki67 |
| author |
Gomez Rosso, Maria Araceli |
| author_facet |
Gomez Rosso, Maria Araceli |
| author_sort |
Gomez Rosso, Maria Araceli |
| title |
Expression of the membrane-associated mucin MUC-1 and its relationship with Ki67 in mucoepidermoid carcinoma of the salivary |
| title_short |
Expression of the membrane-associated mucin MUC-1 and its relationship with Ki67 in mucoepidermoid carcinoma of the salivary |
| title_full |
Expression of the membrane-associated mucin MUC-1 and its relationship with Ki67 in mucoepidermoid carcinoma of the salivary |
| title_fullStr |
Expression of the membrane-associated mucin MUC-1 and its relationship with Ki67 in mucoepidermoid carcinoma of the salivary |
| title_full_unstemmed |
Expression of the membrane-associated mucin MUC-1 and its relationship with Ki67 in mucoepidermoid carcinoma of the salivary |
| title_sort |
expression of the membrane-associated mucin muc-1 and its relationship with ki67 in mucoepidermoid carcinoma of the salivary |
| description |
Background: Salivary gland tumors are rare and with different malignant potential. Immunohistochemistry is useful, especially Ki67, a marker of cell proliferation, for its prognostic information. On the other side, the mucin MUC-1 is overexpressed and loses its exclusively apical membranous localization and is aberrantly glycosylated in mucoepidermoid carcinoma of salivary glands. In the present work, we investigated the quantitative expression of tumor proliferative index and localization and overexpression of MUC-1 in the mucoepidermoid carcinoma of the human salivary glands, not studied is these organs, to determine their relationship with the histological grade and prognosis. Methods: H/E staining and immunohistochemistry with MUC-1 and Ki67 antibodies was performed on 10 cases. Results: The markings of the mucoepidermoid carcinoma depended on the histological grade; in low- grade tumors with MUC-1 only 10 to 25% of the cells were labeled, in contrast to high- grade tumors, with 75 to 90% labeled cells. They also differed in cell proliferation; in the low-grade tumors was 15% and in high-grade tumors it was greater than 30%. Conclusion: MUC-1 overexpression is significantly higher in high-grade mucoepidermoid carcinoma, as is Ki67 marking, results that are associated with tumor prognosis |
| publisher |
Facultad de Odontología |
| publishDate |
2022 |
| url |
https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/39610 |
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