Pleomorphic adenoma of the lacrimal gland: atypical location of a salivary tumor

Introduction: In daily ophthalmological practice, lacrimal gland tumors are rare. They represent 5 to 7.5% of all intraorbital tumors. The most common epithelial tumor of this gland is the pleomorphic adenoma, with a percentage of 25 to 50% of its tumor lesions.Objective: In this communication we pr...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autor principal: Samar, María Elena
Formato: Artículo revista
Lenguaje:Español
Publicado: Facultad de Odontología 2020
Materias:
lacrimal gland, pleomorphic adenoma, histopathology, immunohistochemistry
glándula lagrimal, adenoma pleomórfico, histopatología, inmunohistoquímica
Acceso en línea:https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/31181
Aporte de:
Revista de la Facultad de Odontología de Universidad Nacional de Córdoba
id I10-R335-article-31181
record_format ojs
spelling I10-R335-article-311812020-12-08T11:49:51Z Pleomorphic adenoma of the lacrimal gland: atypical location of a salivary tumor Adenoma pleomórfico de glándula lagrimal: localización atípica de un tumor salival Samar, María Elena lacrimal gland, pleomorphic adenoma, histopathology, immunohistochemistry glándula lagrimal, adenoma pleomórfico, histopatología, inmunohistoquímica Introduction: In daily ophthalmological practice, lacrimal gland tumors are rare. They represent 5 to 7.5% of all intraorbital tumors. The most common epithelial tumor of this gland is the pleomorphic adenoma, with a percentage of 25 to 50% of its tumor lesions.Objective: In this communication we presented a case of lacrimal gland pleomorphic adenoma and study the expression of Ki67 and the location and expression of MUC-1 and its correlation with tumor prognosis. We also carried out a retrospective descriptive study of the literature on the subject published between 1951 and 2020, using the MEDLINE database. Material and methods: The surgical piece examined, was processed according to the paraffin embedding technique, was performed with a histopathological diagnosis of pleomorphic lacrimal gland adenoma. Histological sections were stained with Hematoxylin / Eosin. Immunostaining with Ki67 and MUC-1 was performed with the DAKO LSAB + kit. Results: The diagnosis of hypercellular pleomorphic adenoma with areas of the remaining lacrimal gland was made. Ki67 labeling was low (≤15%). MUC-1 expression was intense, situated to the apical cell membrane of approximately 10% epitheliocytes from pseudoductal and cystic structures.Conclusions: Through histopathological evaluation, the correlation of Ki67 expression and the location and expression of MUC1, we verified that it is a non-recurrent pleomorphic adenoma without malignant transformation. Introducción: En la práctica oftalmológica diaria los tumores de la glándula lagrimal son poco comunes. Representan el 5 a 7,5% de todos los tumores intraorbitarios. El tumor epitelial más común de esta glándula es el adenoma pleomórfico, con un porcentaje de 25 al 50% de sus lesiones tumorales. Objetivo: En esta comunicación presentamos un caso de adenoma pleomórfico de glándula lagrimal y estudiamos la expresión de Ki67 y la localización y expresión de MUC-1 y su correlación con el pronóstico tumoral. Realizamos además un estudio descriptivo retrospectivo de la literatura sobre el tema publicada entre los años 1951 y 2020, usando la base de datos MEDLINE. Material y métodos Se realizó el examen de la pieza quirúrgica, procesada según la técnica de inclusión en parafina, con diagnóstico histopatológico de adenoma pleomórfico de glándula lagrimal. Los cortes histológicos se colorearon con Hematoxilina/Eosina. Se realizó inmunomarcación con Ki67 y MUC-1, con el kit LSAB+ de DAKO. Resultados: Se realizó el diagnóstico de adenoma pleomórfico de tipo hipercelular con áreas de glándula lagrimal remanente. La marcación con Ki67 fue baja (≤15%). La expresión con MUC-1 era intensa, localizada en la membrana celular apical de aproximadamente 10% de los epiteliocitos de las formaciones seudoductales y quísticas. Conclusiones: Por medio de la evaluación histopatológica, la correlación de la expresión de Ki67 y la localización y expresión de MUC1, comprobamos que se trata de un adenoma pleomórfico no recurrente y sin transformación maligna. Facultad de Odontología 2020-12-08 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/31181 Revista de la Facultad de Odontología; Vol. 30 Núm. 3 (2020): Rev Fac Odont vol 30 (3) 2020; 20-28 2545-7594 0325-1071 spa https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/31181/31842 https://creativecommons.org/licenses/by-nc-sa/4.0
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-335
container_title_str Revista de la Facultad de Odontología
language Español
format Artículo revista
topic lacrimal gland, pleomorphic adenoma, histopathology, immunohistochemistry
glándula lagrimal, adenoma pleomórfico, histopatología, inmunohistoquímica
spellingShingle lacrimal gland, pleomorphic adenoma, histopathology, immunohistochemistry
glándula lagrimal, adenoma pleomórfico, histopatología, inmunohistoquímica
Samar, María Elena
Pleomorphic adenoma of the lacrimal gland: atypical location of a salivary tumor
topic_facet lacrimal gland, pleomorphic adenoma, histopathology, immunohistochemistry
glándula lagrimal, adenoma pleomórfico, histopatología, inmunohistoquímica
author Samar, María Elena
author_facet Samar, María Elena
author_sort Samar, María Elena
title Pleomorphic adenoma of the lacrimal gland: atypical location of a salivary tumor
title_short Pleomorphic adenoma of the lacrimal gland: atypical location of a salivary tumor
title_full Pleomorphic adenoma of the lacrimal gland: atypical location of a salivary tumor
title_fullStr Pleomorphic adenoma of the lacrimal gland: atypical location of a salivary tumor
title_full_unstemmed Pleomorphic adenoma of the lacrimal gland: atypical location of a salivary tumor
title_sort pleomorphic adenoma of the lacrimal gland: atypical location of a salivary tumor
description Introduction: In daily ophthalmological practice, lacrimal gland tumors are rare. They represent 5 to 7.5% of all intraorbital tumors. The most common epithelial tumor of this gland is the pleomorphic adenoma, with a percentage of 25 to 50% of its tumor lesions.Objective: In this communication we presented a case of lacrimal gland pleomorphic adenoma and study the expression of Ki67 and the location and expression of MUC-1 and its correlation with tumor prognosis. We also carried out a retrospective descriptive study of the literature on the subject published between 1951 and 2020, using the MEDLINE database. Material and methods: The surgical piece examined, was processed according to the paraffin embedding technique, was performed with a histopathological diagnosis of pleomorphic lacrimal gland adenoma. Histological sections were stained with Hematoxylin / Eosin. Immunostaining with Ki67 and MUC-1 was performed with the DAKO LSAB + kit. Results: The diagnosis of hypercellular pleomorphic adenoma with areas of the remaining lacrimal gland was made. Ki67 labeling was low (≤15%). MUC-1 expression was intense, situated to the apical cell membrane of approximately 10% epitheliocytes from pseudoductal and cystic structures.Conclusions: Through histopathological evaluation, the correlation of Ki67 expression and the location and expression of MUC1, we verified that it is a non-recurrent pleomorphic adenoma without malignant transformation.
publisher Facultad de Odontología
publishDate 2020
url https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/31181
work_keys_str_mv AT samarmariaelena pleomorphicadenomaofthelacrimalglandatypicallocationofasalivarytumor
AT samarmariaelena adenomapleomorficodeglandulalagrimallocalizacionatipicadeuntumorsalival
first_indexed 2024-09-03T21:16:19Z
last_indexed 2024-09-03T21:16:19Z
_version_ 1809211121499897856

Ejemplares similares