HPV-associated Oral Epithelial Dysplasia: A case series
Objective: The aim of this work was to study clinical features of HPV-associated Oral Epithelial Dysplasia (HPV-OED) and evaluate risk factors for this entity. Methods: There were retrieved clinical records of the Oral Pathology Department – Facultad de Odontología, Universidad Nacional de Córdoba w...
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| Autores principales: | , , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Facultad de Odontología
2018
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/18658 |
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| Sumario: | Objective: The aim of this work was to study clinical features of HPV-associated Oral Epithelial Dysplasia (HPV-OED) and evaluate risk factors for this entity. Methods: There were retrieved clinical records of the Oral Pathology Department – Facultad de Odontología, Universidad Nacional de Córdoba with histopathological diagnostic of HPV-OED. Age, sex, site, tobacco and alcohol habit, chief complaint, clinical presentation, mechanical irritation associated, status of adjacent mucosa, presence of histopathologic koilocitosis, degree of epithelial dysplasia and PCR-HPV genotype were studied. Results: We found 11 cases that satisfied the diagnostic criteria for HPV-OED. HPV-OED was presented predominantly in females with a average age of 61 years old. The lateral border of the tongue was the most frequent site of presentation. Tobacco consumption was present in almost all cases. Painless, whitish plaques with a rough surface were the most common clinical presentation. Chronic mechanical irritation (CMI) was observed in nine cases, only two lesions didn´t have association with CMI. Koylocitosis was found in all cases as the most frequent histological feature. HPV-16 was found in 4/11 cases, being the most frequent genotype. Conclusion: Our findings suggest that HPV-OED could have distinctive features from that present in the genital mucosa. There are other risk factors for Oral HPV infection, not present in other mucosae, which should be study due to its influence in the viral cycle such as CMI. Also, further investigations are needed to address the HPV-OED prognosis. |
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