Effects of statins on bone mineral density of postmenopausal women from Córdoba, Argentina
New evidence has emerged on pleiotropic properties of Statins (St), that would be potentially beneficial in the treatment of osteoporosis (OP). Our objective was to study the effect of St on bone mineral density (BMD) in postmenopausal women. Methods: This is a cross-sectional, analytical study, tha...
| Autores principales: | , , , , |
|---|---|
| Formato: | Artículo revista |
| Lenguaje: | Español |
| Publicado: |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2024
|
| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/44652 |
| Aporte de: |
| id |
I10-R327-article-44652 |
|---|---|
| record_format |
ojs |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
bone mineral density statins osteoporosis densidad mineral ósea estatinas osteoporosis densidade mineral óssea estatinas osteoporose |
| spellingShingle |
bone mineral density statins osteoporosis densidad mineral ósea estatinas osteoporosis densidade mineral óssea estatinas osteoporose Astesana, Pablo José Alba, Paula Beatriz Gobbi, Carla Andrea Albiero, Eduardo Horacio Yorio, Marcelo Augusto Alba, Paula Beatriz Gobbi, Carla Andrea Albiero, Eduardo Horacio Yorio, Marcelo Augusto Alba, Paula Beatriz Gobbi, Carla Andrea Albiero, Eduardo Horacio Yorio, Marcelo Augusto Effects of statins on bone mineral density of postmenopausal women from Córdoba, Argentina |
| topic_facet |
bone mineral density statins osteoporosis densidad mineral ósea estatinas osteoporosis densidade mineral óssea estatinas osteoporose |
| author |
Astesana, Pablo José Alba, Paula Beatriz Gobbi, Carla Andrea Albiero, Eduardo Horacio Yorio, Marcelo Augusto Alba, Paula Beatriz Gobbi, Carla Andrea Albiero, Eduardo Horacio Yorio, Marcelo Augusto Alba, Paula Beatriz Gobbi, Carla Andrea Albiero, Eduardo Horacio Yorio, Marcelo Augusto |
| author_facet |
Astesana, Pablo José Alba, Paula Beatriz Gobbi, Carla Andrea Albiero, Eduardo Horacio Yorio, Marcelo Augusto Alba, Paula Beatriz Gobbi, Carla Andrea Albiero, Eduardo Horacio Yorio, Marcelo Augusto Alba, Paula Beatriz Gobbi, Carla Andrea Albiero, Eduardo Horacio Yorio, Marcelo Augusto |
| author_sort |
Astesana, Pablo José |
| title |
Effects of statins on bone mineral density of postmenopausal women from Córdoba, Argentina |
| title_short |
Effects of statins on bone mineral density of postmenopausal women from Córdoba, Argentina |
| title_full |
Effects of statins on bone mineral density of postmenopausal women from Córdoba, Argentina |
| title_fullStr |
Effects of statins on bone mineral density of postmenopausal women from Córdoba, Argentina |
| title_full_unstemmed |
Effects of statins on bone mineral density of postmenopausal women from Córdoba, Argentina |
| title_sort |
effects of statins on bone mineral density of postmenopausal women from córdoba, argentina |
| description |
New evidence has emerged on pleiotropic properties of Statins (St), that would be potentially beneficial in the treatment of osteoporosis (OP).
Our objective was to study the effect of St on bone mineral density (BMD) in postmenopausal women.
Methods: This is a cross-sectional, analytical study, that analyze postmenopausal women with hypercholesterolemia who received treatment with St for at least 6 months, and as a control group (CG), postmenopausal women who did not receive St assisted in two rheumatology services in the city of Córdoba from August 2014 to September 2018.
Results: 202 postmenopausal women received St and 203 constituted the CG. The average age, weight and BMI were 62.54 years, 69.60 kg and 27.13 in the St group vs 58.58 years, 65.70 kg and 26.83 in the control group (p= 0.0001, p= 0.01, p=ns respectively). Lumbar, femoral neck and total hip BMD were statistically higher in patients who received St than in controls (-0.87 vs -1.74 p=0.00, - 1.15 vs 1.56 p= 0.00 and - 0.33 vs - 0.75 p= 0.01). Regarding the time of St treatment, a significant difference was found only in relation to BMD and lumbar spine between the groups of 6 to 12 months and those that received between 12 and 36 months. No relationship was found between BMD and the different types of St received. Conclusion: Treatment with St could improve BMD in hypercholesterolemic postmenopausal women who takes these drugs.
|
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2024 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/44652 |
| work_keys_str_mv |
AT astesanapablojose effectsofstatinsonbonemineraldensityofpostmenopausalwomenfromcordobaargentina AT albapaulabeatriz effectsofstatinsonbonemineraldensityofpostmenopausalwomenfromcordobaargentina AT gobbicarlaandrea effectsofstatinsonbonemineraldensityofpostmenopausalwomenfromcordobaargentina AT albieroeduardohoracio effectsofstatinsonbonemineraldensityofpostmenopausalwomenfromcordobaargentina AT yoriomarceloaugusto effectsofstatinsonbonemineraldensityofpostmenopausalwomenfromcordobaargentina AT albapaulabeatriz effectsofstatinsonbonemineraldensityofpostmenopausalwomenfromcordobaargentina AT gobbicarlaandrea effectsofstatinsonbonemineraldensityofpostmenopausalwomenfromcordobaargentina AT albieroeduardohoracio effectsofstatinsonbonemineraldensityofpostmenopausalwomenfromcordobaargentina AT yoriomarceloaugusto effectsofstatinsonbonemineraldensityofpostmenopausalwomenfromcordobaargentina AT albapaulabeatriz effectsofstatinsonbonemineraldensityofpostmenopausalwomenfromcordobaargentina AT gobbicarlaandrea effectsofstatinsonbonemineraldensityofpostmenopausalwomenfromcordobaargentina AT albieroeduardohoracio effectsofstatinsonbonemineraldensityofpostmenopausalwomenfromcordobaargentina AT yoriomarceloaugusto effectsofstatinsonbonemineraldensityofpostmenopausalwomenfromcordobaargentina AT astesanapablojose efectosdelosestatinasenladensidadmineraloseademujeresposmenopausicadecordobaargentina AT albapaulabeatriz efectosdelosestatinasenladensidadmineraloseademujeresposmenopausicadecordobaargentina AT gobbicarlaandrea efectosdelosestatinasenladensidadmineraloseademujeresposmenopausicadecordobaargentina AT albieroeduardohoracio efectosdelosestatinasenladensidadmineraloseademujeresposmenopausicadecordobaargentina AT yoriomarceloaugusto efectosdelosestatinasenladensidadmineraloseademujeresposmenopausicadecordobaargentina AT albapaulabeatriz efectosdelosestatinasenladensidadmineraloseademujeresposmenopausicadecordobaargentina AT gobbicarlaandrea efectosdelosestatinasenladensidadmineraloseademujeresposmenopausicadecordobaargentina AT albieroeduardohoracio efectosdelosestatinasenladensidadmineraloseademujeresposmenopausicadecordobaargentina AT yoriomarceloaugusto efectosdelosestatinasenladensidadmineraloseademujeresposmenopausicadecordobaargentina AT albapaulabeatriz efectosdelosestatinasenladensidadmineraloseademujeresposmenopausicadecordobaargentina AT gobbicarlaandrea efectosdelosestatinasenladensidadmineraloseademujeresposmenopausicadecordobaargentina AT albieroeduardohoracio efectosdelosestatinasenladensidadmineraloseademujeresposmenopausicadecordobaargentina AT yoriomarceloaugusto efectosdelosestatinasenladensidadmineraloseademujeresposmenopausicadecordobaargentina AT astesanapablojose efeitosdasestatinasnadensidademineralosseademulheresposmenopausasdecordobaargentinaargentina AT albapaulabeatriz efeitosdasestatinasnadensidademineralosseademulheresposmenopausasdecordobaargentinaargentina AT gobbicarlaandrea efeitosdasestatinasnadensidademineralosseademulheresposmenopausasdecordobaargentinaargentina AT albieroeduardohoracio efeitosdasestatinasnadensidademineralosseademulheresposmenopausasdecordobaargentinaargentina AT yoriomarceloaugusto efeitosdasestatinasnadensidademineralosseademulheresposmenopausasdecordobaargentinaargentina AT albapaulabeatriz efeitosdasestatinasnadensidademineralosseademulheresposmenopausasdecordobaargentinaargentina AT gobbicarlaandrea efeitosdasestatinasnadensidademineralosseademulheresposmenopausasdecordobaargentinaargentina AT albieroeduardohoracio efeitosdasestatinasnadensidademineralosseademulheresposmenopausasdecordobaargentinaargentina AT yoriomarceloaugusto efeitosdasestatinasnadensidademineralosseademulheresposmenopausasdecordobaargentinaargentina AT albapaulabeatriz efeitosdasestatinasnadensidademineralosseademulheresposmenopausasdecordobaargentinaargentina AT gobbicarlaandrea efeitosdasestatinasnadensidademineralosseademulheresposmenopausasdecordobaargentinaargentina AT albieroeduardohoracio efeitosdasestatinasnadensidademineralosseademulheresposmenopausasdecordobaargentinaargentina AT yoriomarceloaugusto efeitosdasestatinasnadensidademineralosseademulheresposmenopausasdecordobaargentinaargentina |
| first_indexed |
2025-02-05T22:05:35Z |
| last_indexed |
2025-02-13T23:28:22Z |
| _version_ |
1825820577237041152 |
| spelling |
I10-R327-article-446522025-02-12T14:32:43Z Effects of statins on bone mineral density of postmenopausal women from Córdoba, Argentina Efectos de los estatinas en la densidad mineral ósea de mujeres posmenopáusica de Córdoba, Argentina Efeitos das estatinas na densidade mineral óssea de mulheres pós-menopausas de Córdoba, Argentina , Argentina Astesana, Pablo José Alba, Paula Beatriz Gobbi, Carla Andrea Albiero, Eduardo Horacio Yorio, Marcelo Augusto Alba, Paula Beatriz Gobbi, Carla Andrea Albiero, Eduardo Horacio Yorio, Marcelo Augusto Alba, Paula Beatriz Gobbi, Carla Andrea Albiero, Eduardo Horacio Yorio, Marcelo Augusto bone mineral density statins osteoporosis densidad mineral ósea estatinas osteoporosis densidade mineral óssea estatinas osteoporose New evidence has emerged on pleiotropic properties of Statins (St), that would be potentially beneficial in the treatment of osteoporosis (OP). Our objective was to study the effect of St on bone mineral density (BMD) in postmenopausal women. Methods: This is a cross-sectional, analytical study, that analyze postmenopausal women with hypercholesterolemia who received treatment with St for at least 6 months, and as a control group (CG), postmenopausal women who did not receive St assisted in two rheumatology services in the city of Córdoba from August 2014 to September 2018. Results: 202 postmenopausal women received St and 203 constituted the CG. The average age, weight and BMI were 62.54 years, 69.60 kg and 27.13 in the St group vs 58.58 years, 65.70 kg and 26.83 in the control group (p= 0.0001, p= 0.01, p=ns respectively). Lumbar, femoral neck and total hip BMD were statistically higher in patients who received St than in controls (-0.87 vs -1.74 p=0.00, - 1.15 vs 1.56 p= 0.00 and - 0.33 vs - 0.75 p= 0.01). Regarding the time of St treatment, a significant difference was found only in relation to BMD and lumbar spine between the groups of 6 to 12 months and those that received between 12 and 36 months. No relationship was found between BMD and the different types of St received. Conclusion: Treatment with St could improve BMD in hypercholesterolemic postmenopausal women who takes these drugs. Nuevas evidencias han surgido sobre propiedades pleiotrópicas de las Estatinas (ES) potencialmente beneficiosas en el tratamiento de la osteoporosis (OP). Nuestro objetivo fue estudiar el efecto de las ES sobre la densidad mineral ósea (DMO) en mujeres posmenopáusicas. Métodos: Estudio de corte transversal, analítico, se estudiaron mujeres posmenopáusicas con hipercolesterolemia que recibieron tratamiento con ES de al menos 6 meses de duración, y como grupo control (GC) mujeres posmenopáusicas que no recibieron ES asistidas en dos servicios de reumatología de la ciudad de Córdoba desde agosto de 2014 hasta septiembre de 2018. Resultados: 202 mujeres posmenopáusicas recibieron estatinas (ES) y 203 constituyeron el GC. La edad promedio, peso e IMC fue de 62,54 años, 69,60 kg y 27,13 en el grupo ES vs 58,58 años, 65,70 kg y 26,83 en el grupo control (p= 0,0001, p= 0,01, p=ns respectivamente). La DMO lumbar, de cuello femoral y de cadera total fue estadísticamente más alta en pacientes que recibieron ES que en controles (-0,87 vs -1,74 p=0,00, - 1.15 vs 1,56 p= 0,00 y - 0,33 vs - 0,75 p= 0,01). En cuanto al tiempo de tratamiento ES, se encontró diferencia significativa solamente en relación a DMO y columna lumbar entre los grupos de 6 a 12 meses y los que recibieron entre 12 y 36 meses. No se encontró relación entre la DMO y los diferentes tipos de ES recibidas. Conclusión: El tratamiento con ES podría ser beneficioso en mejorar la DMO en mujeres posmenopáusicas hipercolesterolémicas medicados con dichos fármacos. Novas evidências surgiram sobre as propriedades pleiotrópicas das estatinas (ES), potencialmente benéficas no tratamento da osteoporose (OP). Nosso objetivo foi estudar o efeito do ES na densidade mineral óssea (DMO) em mulheres na pós-menopausa. Métodos: Estudo transversal, analítico, foram estudadas mulheres na pós-menopausa com hipercolesterolemia que receberam tratamento com ES por pelo menos 6 meses, e como grupo controle (GC), mulheres na pós-menopausa que não receberam ES atendidas em dois serviços de reumatologia do município de Córdoba de agosto de 2014 a setembro de 2018. Resultados: 202 mulheres na pós-menopausa receberam estatinas (ES) e 203 constituíram o GC. A média de idade, peso e IMC foram 62,54 anos, 69,60 kg e 27,13 no grupo ES vs 58,58 anos, 65,70 kg e 26,83 no grupo controle (p= 0,0001, p= 0,01, p=ns respectivamente). A DMO lombar, do colo femoral e total do quadril foi estatisticamente maior nos pacientes que receberam ES do que nos controles (-0,87 vs -1,74 p=0,00, - 1,15 vs 1,56 p= 0,00 e - 0,33 vs - 0,75 p= 0,01). Em relação ao tempo de tratamento da ES, foi encontrada diferença significativa apenas em relação à DMO e à coluna lombar entre os grupos de 6 a 12 meses e aqueles que receberam entre 12 e 36 meses. Nenhuma relação foi encontrada entre a DMO e os diferentes tipos de SE recebidos. Conclusão: O tratamento com ES pode ser benéfico na melhoria da DMO em mulheres hipercolesterolêmicas na pós-menopausa medicadas com esses medicamentos. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2024-12-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion text/html application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/44652 10.31053/1853.0605.v81.n4.44652 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 81 No. 4 (2024); 719-733 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 81 Núm. 4 (2024); 719-733 Revista da Faculdade de Ciências Médicas de Córdoba; v. 81 n. 4 (2024); 719-733 1853-0605 0014-6722 10.31053/1853.0605.v81.n4 spa https://revistas.unc.edu.ar/index.php/med/article/view/44652/47700 https://revistas.unc.edu.ar/index.php/med/article/view/44652/47499 Derechos de autor 2024 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0 |