Unveiling Hormonal Secrets: a Review of Hypothyroidism in Pregnancy through Clinical Cases
Background: Thyroid dysfunction during pregnancy negatively impacts both the woman and her offspring, with the early gestational period being critical for potential repercussions. Establishing pre-conception and during-conception care strategies is crucial for favorable pregnancy outcomes. Objective...
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2024
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/44304 |
| Aporte de: |
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I10-R327-article-44304 |
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Universidad Nacional de Córdoba |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
pregnancy complications primary health care hypothyroidism thyroid gland hipotiroidismo complicaciones del embarazo atención primaria de salud glándula tiroides complicações na gravidez hipotireoidismo atenção primária à saúde glândula tireoide |
| spellingShingle |
pregnancy complications primary health care hypothyroidism thyroid gland hipotiroidismo complicaciones del embarazo atención primaria de salud glándula tiroides complicações na gravidez hipotireoidismo atenção primária à saúde glândula tireoide García Ramos, Andrés Felipe Monsalve Arango , Claudia Botero Arango, Jose Fernando Aristizabal Henao, Natalia Buitrago Gómez , Nathalia Cabarcas Lopez, William Fernando Unveiling Hormonal Secrets: a Review of Hypothyroidism in Pregnancy through Clinical Cases |
| topic_facet |
pregnancy complications primary health care hypothyroidism thyroid gland hipotiroidismo complicaciones del embarazo atención primaria de salud glándula tiroides complicações na gravidez hipotireoidismo atenção primária à saúde glândula tireoide |
| author |
García Ramos, Andrés Felipe Monsalve Arango , Claudia Botero Arango, Jose Fernando Aristizabal Henao, Natalia Buitrago Gómez , Nathalia Cabarcas Lopez, William Fernando |
| author_facet |
García Ramos, Andrés Felipe Monsalve Arango , Claudia Botero Arango, Jose Fernando Aristizabal Henao, Natalia Buitrago Gómez , Nathalia Cabarcas Lopez, William Fernando |
| author_sort |
García Ramos, Andrés Felipe |
| title |
Unveiling Hormonal Secrets: a Review of Hypothyroidism in Pregnancy through Clinical Cases |
| title_short |
Unveiling Hormonal Secrets: a Review of Hypothyroidism in Pregnancy through Clinical Cases |
| title_full |
Unveiling Hormonal Secrets: a Review of Hypothyroidism in Pregnancy through Clinical Cases |
| title_fullStr |
Unveiling Hormonal Secrets: a Review of Hypothyroidism in Pregnancy through Clinical Cases |
| title_full_unstemmed |
Unveiling Hormonal Secrets: a Review of Hypothyroidism in Pregnancy through Clinical Cases |
| title_sort |
unveiling hormonal secrets: a review of hypothyroidism in pregnancy through clinical cases |
| description |
Background: Thyroid dysfunction during pregnancy negatively impacts both the woman and her offspring, with the early gestational period being critical for potential repercussions. Establishing pre-conception and during-conception care strategies is crucial for favorable pregnancy outcomes. Objective: This review aims to compile the most recent scientific evidence to guide diagnostic and therapeutic approaches based on clinical cases, including a description of thyroid physiology during pregnancy and strategies for identifying high-risk patients for treatment. Method: This bibliographic review combined DeCS and MeSH terms from the PICOT question, spanning the period from 2015 to 2022 across 5 databases. Articles in both English and Spanish were included if they addressed the PICOT question and contributed to the explanation of two case reports. Results: A total of 1452 articles were collected, which, following an initial elimination of duplicates and subsequent blind review based on inclusion and exclusion criteria by two reviewers, resulted in 32 articles included in this review. Conclusions: Overt hypothyroidism is associated with adverse maternal-fetal outcomes, and its treatment improves these complications. However, in borderline conditions such as subclinical hypothyroidism, isolated hypothyroxinemia, and thyroid autoimmune conditions, uncertainty about the treatment's impact persists due to a scarcity of controlled trials. Emphasizing the importance of all physicians being familiar with this condition during gestation. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2024 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/44304 |
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I10-R327-article-443042024-12-13T14:58:47Z Unveiling Hormonal Secrets: a Review of Hypothyroidism in Pregnancy through Clinical Cases Desvelando Secretos Hormonales: una revisión del Hipotiroidismo en el Embarazo a través de Casos Clínicos Revelando Segredos Hormonais: uma revisão do Hipotireoidismo na Gravidez através de Casos Clínicos García Ramos, Andrés Felipe Monsalve Arango , Claudia Botero Arango, Jose Fernando Aristizabal Henao, Natalia Buitrago Gómez , Nathalia Cabarcas Lopez, William Fernando pregnancy complications primary health care hypothyroidism thyroid gland hipotiroidismo complicaciones del embarazo atención primaria de salud glándula tiroides complicações na gravidez hipotireoidismo atenção primária à saúde glândula tireoide Background: Thyroid dysfunction during pregnancy negatively impacts both the woman and her offspring, with the early gestational period being critical for potential repercussions. Establishing pre-conception and during-conception care strategies is crucial for favorable pregnancy outcomes. Objective: This review aims to compile the most recent scientific evidence to guide diagnostic and therapeutic approaches based on clinical cases, including a description of thyroid physiology during pregnancy and strategies for identifying high-risk patients for treatment. Method: This bibliographic review combined DeCS and MeSH terms from the PICOT question, spanning the period from 2015 to 2022 across 5 databases. Articles in both English and Spanish were included if they addressed the PICOT question and contributed to the explanation of two case reports. Results: A total of 1452 articles were collected, which, following an initial elimination of duplicates and subsequent blind review based on inclusion and exclusion criteria by two reviewers, resulted in 32 articles included in this review. Conclusions: Overt hypothyroidism is associated with adverse maternal-fetal outcomes, and its treatment improves these complications. However, in borderline conditions such as subclinical hypothyroidism, isolated hypothyroxinemia, and thyroid autoimmune conditions, uncertainty about the treatment's impact persists due to a scarcity of controlled trials. Emphasizing the importance of all physicians being familiar with this condition during gestation. Antecedentes: La disfunción tiroidea durante la gestación impacta negativamente a la mujer y su descendencia, siendo el periodo temprano de gestación crítico para posibles repercusiones. Establecer estrategias de atención previas y durante la concepción es crucial para resultados favorables en el embarazo. Objetivo: Esta revisión es recopilar la evidencia científica más reciente para orientar el abordaje diagnóstico y terapéutico basado en casos clínicos, incluyendo la descripción de la fisiología tiroidea durante el embarazo y estrategias de identificación de pacientes de alto riesgo para tratamiento. Método: Esta revisión bibliográfica combinó términos DeCs y MeSH de la pregunta PICOT, abarcando el periodo entre 2015 y 2022 en 5 bases de datos. Se incluyeron artículos en inglés y español que respondieran a la pregunta PICOT y contribuyeran a la explicación de dos reportes de caso. Resultados: Se recolectaron 1452 artículos, los cuales posterior a una eliminación por duplicidad en primera instancia y posterior filtración según criterios de inclusión y exclusión realizada por 2 revisores de manera ciega se obtuvieron 32 artículos los cuales fueron incluidos en esta revisión. Conclusiones: el hipotiroidismo manifiesto se relaciona con desenlaces negativos materno-fetales y su tratamiento mejora estas complicaciones. Sin embargo, en estados limítrofes como hipotiroidismo subclínico, hipotiroxinemia aislada y autoinmunidad tiroidea, la incertidumbre sobre el impacto del tratamiento persiste debido a la escasez de ensayos controlados. Se subraya la importancia de que todos los médicos estén familiarizados con esta condición durante la gestación. Antecedentes: A disfunção tireoidiana durante a gestação impacta negativamente a mulher e sua descendência, sendo o período inicial da gestação crítico para possíveis repercussões. Estabelecer estratégias de atenção prévia e durante a concepção é crucial para resultados favoráveis na gravidez. Objetivo: Esta revisão tem como objetivo reunir as evidências científicas mais recentes para orientar a abordagem diagnóstica e terapêutica baseada em casos clínicos, incluindo a descrição da fisiologia tireoidiana durante a gravidez e estratégias de identificação de pacientes de alto risco para tratamento. Método: Esta revisão bibliográfica combinou termos DeCs e MeSH da pergunta PICOT, abrangendo o período entre 2015 e 2022 em 5 bases de dados. Foram incluídos artigos em inglês e espanhol que respondessem à pergunta PICOT e contribuíssem para a explicação de dois relatos de casos. Resultados: Foram coletados 1452 artigos, os quais, após uma eliminação por duplicidade em primeira instância e posterior filtragem de acordo com critérios de inclusão e exclusão realizada por 2 revisores de maneira cega, resultaram em 32 artigos incluídos nesta revisão. Conclusões: O hipotiroidismo manifesto está relacionado a desfechos negativos materno-fetais e seu tratamento melhora essas complicações. No entanto, em estados limítrofes como hipotiroidismo subclínico, hipotireoidismo isolado e autoimunidade tireoidiana, a incerteza sobre o impacto do tratamento persiste devido à escassez de ensaios controlados. É enfatizada a importância de que todos os médicos estejam familiarizados com essa condição durante a gestação. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2024-12-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html https://revistas.unc.edu.ar/index.php/med/article/view/44304 10.31053/1853.0605.v81.n4.44304 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 81 No. 4 (2024); 824-841 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 81 Núm. 4 (2024); 824-841 Revista da Faculdade de Ciências Médicas de Córdoba; v. 81 n. 4 (2024); 824-841 1853-0605 0014-6722 10.31053/1853.0605.v81.n4 spa https://revistas.unc.edu.ar/index.php/med/article/view/44304/47626 https://revistas.unc.edu.ar/index.php/med/article/view/44304/47165 Derechos de autor 2024 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0 |