Plasma cell myeloma: a case report
Introduction: Plasma Cell Myeloma or Multiple Myeloma (MM) is the most frequent plasma cell neoplasm of malignant monoclonal gammopathies. Frequently present between the ages of 60 and 70. They are disorders characterized by clonal proliferation of immunoglobulin-secreting plasma cells from a single...
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/43206 |
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I10-R327-article-43206 |
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Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
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Artículo revista |
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Myeloma Plasma Cell Myeloma Multiple Myeloma Mieloma Mieloma de Células Plasmáticas Mieloma Múltiple . |
| spellingShingle |
Myeloma Plasma Cell Myeloma Multiple Myeloma Mieloma Mieloma de Células Plasmáticas Mieloma Múltiple . Mondino , F Madrid Fernández , TA Szlabi , S Rivas , DA Defazio , N Plasma cell myeloma: a case report |
| topic_facet |
Myeloma Plasma Cell Myeloma Multiple Myeloma Mieloma Mieloma de Células Plasmáticas Mieloma Múltiple . |
| author |
Mondino , F Madrid Fernández , TA Szlabi , S Rivas , DA Defazio , N |
| author_facet |
Mondino , F Madrid Fernández , TA Szlabi , S Rivas , DA Defazio , N |
| author_sort |
Mondino , F |
| title |
Plasma cell myeloma: a case report |
| title_short |
Plasma cell myeloma: a case report |
| title_full |
Plasma cell myeloma: a case report |
| title_fullStr |
Plasma cell myeloma: a case report |
| title_full_unstemmed |
Plasma cell myeloma: a case report |
| title_sort |
plasma cell myeloma: a case report |
| description |
Introduction: Plasma Cell Myeloma or Multiple Myeloma (MM) is the most frequent plasma cell neoplasm of malignant monoclonal gammopathies. Frequently present between the ages of 60 and 70. They are disorders characterized by clonal proliferation of immunoglobulin-secreting plasma cells from a single progenitor cell. This condition is presented with typical symptoms and signs, such as bone pain, hypercalcemia, bone fractures, kidney damage, anemic syndrome, neurological symptoms and recurrent infections. The objective of our work is report a case of MM, review its medical clinic, form of presentation, macro and microscopic appearance, with its respective immunohistochemistry, immunophenotyping, biological behavior and prognosis, comparing it with other similar cases.
Case presentation: It was a 62-year-old woman with severe humeral bone pain. The physical examination and imaging studies suspected a tumor lesion on her humerus, and others were discovered in the ribs, vertebrae and pelvis. A biopsy was taken for pathological analysis, which reported poorly differentiated neoplasia with numerous "plasmacytoid" type cells. Immunohistochemistry was positive for CD138 and CD79a. In addition, a biopsy of the iliac bone marrow was requested, which revealed hypercellularity with interstitial-like infiltration of mature-appearing plasma cells. Immunophenotyping indicated 1.5% of plasma cells, of which 99% presented restriction in the expression of cytoplasmic immunoglobulins, lambda light chain; with the phenotype: CD45-/CD38+/ CD138+/CD56+/ CD19-; linkable to abnormal plasma cells. The multiple osteolytic lesions, conjointly with the data obtained by histopathology, the immunohistochemically profile and the immunophenotyping, were found to be associated to plasma cell myeloma. The patient was treated with chemotherapy, being her evolution favourable with 6 months of follow-up.
Conclusions: MM is the most frequent plasma cell neoplasm, characterized by clonal proliferation of immunoglobulin-secreting plasma cells. They are usually classified into secretory or non-secretory MM, being the non-secretory with the most unfavorable prognosis. Our case agree, from the clinical view, the anatomopathological, immunohistochemical and immunophenotypic findings, with what is described in the consulted bibliography. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/43206 |
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AT mondinof plasmacellmyelomaacasereport AT madridfernandezta plasmacellmyelomaacasereport AT szlabis plasmacellmyelomaacasereport AT rivasda plasmacellmyelomaacasereport AT defazion plasmacellmyelomaacasereport AT mondinof mielomadecelulasplasmaticasreportedeuncaso AT madridfernandezta mielomadecelulasplasmaticasreportedeuncaso AT szlabis mielomadecelulasplasmaticasreportedeuncaso AT rivasda mielomadecelulasplasmaticasreportedeuncaso AT defazion mielomadecelulasplasmaticasreportedeuncaso |
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2024-09-03T21:05:06Z |
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2024-09-03T21:05:06Z |
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| spelling |
I10-R327-article-432062024-04-15T16:19:09Z Plasma cell myeloma: a case report Mieloma de células plasmáticas: reporte de un caso . Mondino , F Madrid Fernández , TA Szlabi , S Rivas , DA Defazio , N Myeloma Plasma Cell Myeloma Multiple Myeloma Mieloma Mieloma de Células Plasmáticas Mieloma Múltiple . Introduction: Plasma Cell Myeloma or Multiple Myeloma (MM) is the most frequent plasma cell neoplasm of malignant monoclonal gammopathies. Frequently present between the ages of 60 and 70. They are disorders characterized by clonal proliferation of immunoglobulin-secreting plasma cells from a single progenitor cell. This condition is presented with typical symptoms and signs, such as bone pain, hypercalcemia, bone fractures, kidney damage, anemic syndrome, neurological symptoms and recurrent infections. The objective of our work is report a case of MM, review its medical clinic, form of presentation, macro and microscopic appearance, with its respective immunohistochemistry, immunophenotyping, biological behavior and prognosis, comparing it with other similar cases. Case presentation: It was a 62-year-old woman with severe humeral bone pain. The physical examination and imaging studies suspected a tumor lesion on her humerus, and others were discovered in the ribs, vertebrae and pelvis. A biopsy was taken for pathological analysis, which reported poorly differentiated neoplasia with numerous "plasmacytoid" type cells. Immunohistochemistry was positive for CD138 and CD79a. In addition, a biopsy of the iliac bone marrow was requested, which revealed hypercellularity with interstitial-like infiltration of mature-appearing plasma cells. Immunophenotyping indicated 1.5% of plasma cells, of which 99% presented restriction in the expression of cytoplasmic immunoglobulins, lambda light chain; with the phenotype: CD45-/CD38+/ CD138+/CD56+/ CD19-; linkable to abnormal plasma cells. The multiple osteolytic lesions, conjointly with the data obtained by histopathology, the immunohistochemically profile and the immunophenotyping, were found to be associated to plasma cell myeloma. The patient was treated with chemotherapy, being her evolution favourable with 6 months of follow-up. Conclusions: MM is the most frequent plasma cell neoplasm, characterized by clonal proliferation of immunoglobulin-secreting plasma cells. They are usually classified into secretory or non-secretory MM, being the non-secretory with the most unfavorable prognosis. Our case agree, from the clinical view, the anatomopathological, immunohistochemical and immunophenotypic findings, with what is described in the consulted bibliography. Introducción: El Mieloma de Células Plasmáticas o Mieloma Múltiple (MM) es la neoplasia de células plasmáticas más frecuente de las gammapatías monoclonales malignas. Se presentan frecuentemente entre los 60 y 70 años. Constituyen trastornos caracterizados por proliferación clonal de células plasmáticas secretoras de inmunoglobulinas a partir de una única célula progenitora. Esta afección cursa con síntomas y signos característicos, entre los que destacan dolor óseo, hipercalcemia, fracturas óseas, daño renal, síndrome anémico, síntomas neurológicos e infecciones recurrentes. El objetivo de nuestro trabajo es comunicar un caso de MM, repasar su clínica, forma de presentación, apariencia macro y microscópica, con su respectiva inmunohistoquimica, inmunofenotipificación, comportamiento biológico y su pronóstico, comparándolo con otros casos similares. Presentación del caso: Se trató de una mujer de 62 años con intenso dolor óseo a nivel humeral. Al examen físico e imagenológico se sospechó de lesión tumoral del húmero y se descubrió otras en costillas, vértebras y pelvis. Se procedió a tomar biopsia para análisis patológico, la cual informó neoplasia poco diferenciada con numerosas células de tipo “plasmocitoide”. La inmunohistoquímica dio positivo para CD138 y CD79a. Aparte se solicitó biopsia de medula ósea ilíaca, que reveló hipercelularidad con infiltración tipo intersticial de células plasmáticas de apariencia madura. La inmunofenotipificación indicó 1,5% de células plasmáticas, de las cuales el 99% presentaba restricción en la expresión de inmunoglobulinas citoplasmáticas, cadena liviana lambda; con el fenotipo: CD45-/CD38+/CD138+/CD56+/CD19-; vinculable a plasmocitos anormales. Las lesiones osteolíticas múltiples, junto con los datos arrojados por histopatología, el perfil inmunohistoquímico y de inmunofenotipificación, resultaron vinculables a mieloma de células plasmáticas. La paciente fue tratada con quimioterapia, siendo su evolución favorable con 6 meses de seguimiento. Conclusiones: El MM es la neoplasia de células plasmáticas más frecuente, caracterizada por proliferación clonal de células plasmáticas secretoras de inmunoglobulinas. Se suelen diferenciar en MM secretor o no secretor, siendo este último de pronóstico más desfavorable. Nuestro caso coincidió, desde el punto de vista clínico, hallazgos anatomopatológicos, inmunohistoquímicos e inmunofenotipicos, con lo descripto en la bibliografía consultada. . Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-10-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://revistas.unc.edu.ar/index.php/med/article/view/43206 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. Suplemento (2021): Suplemento JIC XXII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. Suplemento (2021): Suplemento JIC XXII Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. Suplemento (2021): Suplemento JIC XXII 1853-0605 0014-6722 Derechos de autor 2021 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0 |