Seroprevalence of human parvovirus B19 in pregnant women in Córdoba, 2021-2022

Human parvovirus B19 (B19V) infection acquired during pregnancy can be transmitted to the fetus and cause serious complications such as hydrops and stillbirth. The presence of IgG-specific antibodies (without evidence of recent infection) is considered a protective factor for vertical transmission....

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Detalles Bibliográficos
Autores principales: Dicuatro, NE, Moreno , LB, Lucchini , H, Adamo, MP, Boggio , GA, Colazo Salbetti, B, Ortiz, E, Pedranti, M
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2023
Materias:
parvovirus b19
fetal hydrops
seroprevalence
Parvovirius B19
hidropesía fetal
seroprevalencia
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/42667
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
id I10-R327-article-42667
record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Español
format Artículo revista
topic parvovirus b19
fetal hydrops
seroprevalence
Parvovirius B19
hidropesía fetal
seroprevalencia
spellingShingle parvovirus b19
fetal hydrops
seroprevalence
Parvovirius B19
hidropesía fetal
seroprevalencia
Dicuatro, NE
Moreno , LB
Lucchini , H
Adamo, MP
Boggio , GA
Colazo Salbetti, B
Ortiz, E
Pedranti, M
Seroprevalence of human parvovirus B19 in pregnant women in Córdoba, 2021-2022
topic_facet parvovirus b19
fetal hydrops
seroprevalence
Parvovirius B19
hidropesía fetal
seroprevalencia
author Dicuatro, NE
Moreno , LB
Lucchini , H
Adamo, MP
Boggio , GA
Colazo Salbetti, B
Ortiz, E
Pedranti, M
author_facet Dicuatro, NE
Moreno , LB
Lucchini , H
Adamo, MP
Boggio , GA
Colazo Salbetti, B
Ortiz, E
Pedranti, M
author_sort Dicuatro, NE
title Seroprevalence of human parvovirus B19 in pregnant women in Córdoba, 2021-2022
title_short Seroprevalence of human parvovirus B19 in pregnant women in Córdoba, 2021-2022
title_full Seroprevalence of human parvovirus B19 in pregnant women in Córdoba, 2021-2022
title_fullStr Seroprevalence of human parvovirus B19 in pregnant women in Córdoba, 2021-2022
title_full_unstemmed Seroprevalence of human parvovirus B19 in pregnant women in Córdoba, 2021-2022
title_sort seroprevalence of human parvovirus b19 in pregnant women in córdoba, 2021-2022
description Human parvovirus B19 (B19V) infection acquired during pregnancy can be transmitted to the fetus and cause serious complications such as hydrops and stillbirth. The presence of IgG-specific antibodies (without evidence of recent infection) is considered a protective factor for vertical transmission. Seroprevalence in women of childbearing age is variable (50-80%) and depends on geography/virus circulation, as well as factors such as maternal age and frequent exposure to children. Objective: to determine the seroprevalence of B19V in pregnant women attending the Hospital Universitario de Maternidad y Neonatología (HUMN) during 2021-2022 and to analyze the association of specific IgG with age and family contact with children under 15 years of age. We carried out an observational, analytical-cross-sectional study. Previously healthy pregnant women treated at HUMN were included after signing an informed consent. Determination of IgG anti-B19V was performed in all patients; In cases with parvoviral signs/symptoms during pregnancy, specific IgM and viral DNA were determined. By means of bivariate analysis, the association with the predictive factors was evaluated (p<0.05). A total of 318 cases were studied; mean age was 28.6±6 years (range 16-46). IgG anti-B19V was detected in 218/318 (68.5%). Contact with children under 15 years of age was registered in 155/318 (48.7%). Acute/recent infection (IgM/DNA+) was identified in 12 cases, 11/12 with anemia and 1 asymptomatic; 1 case of vertical transmission was detected (hydrops in RN; IgM/DNA+). No association was found between seroprevalence and age (p=0.39) or family exposure to children (p=0.69). The seroprevalence of B19V in our population of pregnant women in the study period was 68.5% regardless of maternal age or family exposure to children. In the period studied, 32.5% remained unexposed to the virus, indicating susceptibility to contracting the infection in the future.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2023
url https://revistas.unc.edu.ar/index.php/med/article/view/42667
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spelling I10-R327-article-426672023-10-19T21:20:07Z Seroprevalence of human parvovirus B19 in pregnant women in Córdoba, 2021-2022 Seroprevalencia de parvovirus humano B19 en embarazadas de Córdoba, 2021-2022 Dicuatro, NE Moreno , LB Lucchini , H Adamo, MP Boggio , GA Colazo Salbetti, B Ortiz, E Pedranti, M parvovirus b19 fetal hydrops seroprevalence Parvovirius B19 hidropesía fetal seroprevalencia Human parvovirus B19 (B19V) infection acquired during pregnancy can be transmitted to the fetus and cause serious complications such as hydrops and stillbirth. The presence of IgG-specific antibodies (without evidence of recent infection) is considered a protective factor for vertical transmission. Seroprevalence in women of childbearing age is variable (50-80%) and depends on geography/virus circulation, as well as factors such as maternal age and frequent exposure to children. Objective: to determine the seroprevalence of B19V in pregnant women attending the Hospital Universitario de Maternidad y Neonatología (HUMN) during 2021-2022 and to analyze the association of specific IgG with age and family contact with children under 15 years of age. We carried out an observational, analytical-cross-sectional study. Previously healthy pregnant women treated at HUMN were included after signing an informed consent. Determination of IgG anti-B19V was performed in all patients; In cases with parvoviral signs/symptoms during pregnancy, specific IgM and viral DNA were determined. By means of bivariate analysis, the association with the predictive factors was evaluated (p<0.05). A total of 318 cases were studied; mean age was 28.6±6 years (range 16-46). IgG anti-B19V was detected in 218/318 (68.5%). Contact with children under 15 years of age was registered in 155/318 (48.7%). Acute/recent infection (IgM/DNA+) was identified in 12 cases, 11/12 with anemia and 1 asymptomatic; 1 case of vertical transmission was detected (hydrops in RN; IgM/DNA+). No association was found between seroprevalence and age (p=0.39) or family exposure to children (p=0.69). The seroprevalence of B19V in our population of pregnant women in the study period was 68.5% regardless of maternal age or family exposure to children. In the period studied, 32.5% remained unexposed to the virus, indicating susceptibility to contracting the infection in the future. La infección por parvovirus humano B19/B19V adquirida durante el embarazo puede transmitirse al feto y ocasionar complicaciones graves como hidropesía y muerte fetal. La presencia de IgG-específica (sin evidencia de infección reciente) se considera un factor protector para la transmisión vertical. La seroprevalencia en mujeres en edad fértil es variable (50-80%) y depende de la geografía/circulación viral, además de factores como edad materna y exposición frecuente a población infantil. Objetivo: determinar seroprevalencia de B19V en embarazadas atendidas en el Hospital Universitario de Maternidad y Neonatología/HUMN (2021-2022) y analizar asociación con edad y contacto familiar con menores de 15 años.  Diseño observacional, analítico-transversal. Fueron incluidas embarazadas previamente sanas atendidas en el HUMN previa firma de consentimiento informado. Se realizó determinación en sangre de IgG-específica para B19V en todas las pacientes; en los casos con signos/síntomas parvovirales durante la gestación se determinó IgM específica y ADN viral. Mediante análisis bivariado se evaluó la asociación con los factores predictores (p<0,05). Se estudiaron 318 casos; edad 28,6±6 años (16-46). Se detectó IgG B19V en 218/318 (68.5%). Convivientes con menores: 155/318 (48,7%). En 12 casos se identificó infección aguda/reciente (IgM/ADN+), 11/12 con anemia/1 asintomática; se registró 1 caso de transmisión vertical (hidropesía en RN; IgM/ADN+). No se encontró asociación entre seroprevalencia y edad (p=0,39) ni exposición familiar a menores (p=0,69).  La seroprevalencia de B19V en nuestra población de embarazadas en el período estudiado fue 68,5% independientemente de la edad materna o exposición familiar a menores. Quedan 32,5% no expuestas al virus, susceptibles a contraer la infección en el futuro. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2023-10-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/42667 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 80 (2023): Suplemento JIC XXIV Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 80 (2023): Suplemento JIC XXIV Revista da Faculdade de Ciências Médicas de Córdoba; v. 80 (2023): Suplemento JIC XXIV 1853-0605 0014-6722 spa https://revistas.unc.edu.ar/index.php/med/article/view/42667/42863 Derechos de autor 2023 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0

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