Apolipoprotein-A1 gene variants in the development of chronic chagasic cardiomyopathy
In recent years, genetic approaches to study the development/progression of Chagasic cardiomyopathy have focused on genes related to the immune response; few have studied genes associated with cardiac function. The present work delves into the results presented previously, with the aim of completing...
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| Autores principales: | , , , , , , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2023
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| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/42647 |
| Aporte de: |
| Sumario: | In recent years, genetic approaches to study the development/progression of Chagasic cardiomyopathy have focused on genes related to the immune response; few have studied genes associated with cardiac function. The present work delves into the results presented previously, with the aim of completing the analysis of the role played by the genetic variants of Apolipoprotein-A1 (APO-A1) in the development of chronic Chagasic cardiomyopathy, in patients from the Province of Córdoba. APO-A1 is the main component of high-density lipoproteins; polymorphisms in this gene have been associated with coronary disease in different populations.
Blood samples from 172 patients (51 men and 121 women) with positive serology for Chagas disease, from the city of Córdoba (Hospital Nacional de Clínicas, Clínica Sucre and Hospital San Roque) were analyzed. The patients were classified as: G1 (n=89): without cardiac alterations, G2 (n=57): with mild cardiac alterations (electrocardiographic alterations), and G3 (n=26): with severe cardiac alterations (electrocardiographic and echocardiographic alterations). APO-A1 G-75A (rs670) and C+83T (rs5069) polymorphisms were determined by PCR-RFLP. Differences between allelic, genotypic and haplotype frequencies were analyzed in relation to the development (G1 vs G2+G3) or progression (G2 vs G3) of Chagasic cardiomyopathy, using chi-square/Fisher's exact test and logistic regression.
Both allele and genotypic frequencies for both polymorphisms were similar among the three groups studied and were not associated with the development or the progression of the cardiomyopathy. No differences were observed between men and women. Exposure to the less frequent allele of each polymorphism was not related to the development [OR rs670_A = 1.24 (0.81-1.9); OR rs5069_T = 1.22 (0.79-1.86)] or with the progression [OR rs670_A = 1.33 (0.69-2.55); OR rs5069_T = 1.55 (0.80-2.98)] of chagasic cardiomyopathy. No differences were found in the frequencies of haplotypes or homozygous/heterozygous between the groups studied.
The results obtained reaffirm what was previously reported (in this case, with a larger number of patients) and suggest that APO-A1 genetic variants would not have a significant contribution in the development of chronic Chagasic cardiomyopathy in the population studied. |
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