Apolipoprotein-A1 gene variants in the development of chronic chagasic cardiomyopathy
In recent years, genetic approaches to study the development/progression of Chagasic cardiomyopathy have focused on genes related to the immune response; few have studied genes associated with cardiac function. The present work delves into the results presented previously, with the aim of completing...
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| Formato: | Artículo revista |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2023
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/42647 |
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I10-R327-article-42647 |
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ojs |
| institution |
Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
APO-A1 polymorphisms chagasic cardiomyopathy association study Polimorfismos de APO-A1 Miocardiopatia chagasica estudio de asociación |
| spellingShingle |
APO-A1 polymorphisms chagasic cardiomyopathy association study Polimorfismos de APO-A1 Miocardiopatia chagasica estudio de asociación Velázquez López , DA Gómez, DS Fernández Spector , H Argüello Hoyos, P Blasco , R Bazán, PC Báez , AL Lo Presti, MS Apolipoprotein-A1 gene variants in the development of chronic chagasic cardiomyopathy |
| topic_facet |
APO-A1 polymorphisms chagasic cardiomyopathy association study Polimorfismos de APO-A1 Miocardiopatia chagasica estudio de asociación |
| author |
Velázquez López , DA Gómez, DS Fernández Spector , H Argüello Hoyos, P Blasco , R Bazán, PC Báez , AL Lo Presti, MS |
| author_facet |
Velázquez López , DA Gómez, DS Fernández Spector , H Argüello Hoyos, P Blasco , R Bazán, PC Báez , AL Lo Presti, MS |
| author_sort |
Velázquez López , DA |
| title |
Apolipoprotein-A1 gene variants in the development of chronic chagasic cardiomyopathy |
| title_short |
Apolipoprotein-A1 gene variants in the development of chronic chagasic cardiomyopathy |
| title_full |
Apolipoprotein-A1 gene variants in the development of chronic chagasic cardiomyopathy |
| title_fullStr |
Apolipoprotein-A1 gene variants in the development of chronic chagasic cardiomyopathy |
| title_full_unstemmed |
Apolipoprotein-A1 gene variants in the development of chronic chagasic cardiomyopathy |
| title_sort |
apolipoprotein-a1 gene variants in the development of chronic chagasic cardiomyopathy |
| description |
In recent years, genetic approaches to study the development/progression of Chagasic cardiomyopathy have focused on genes related to the immune response; few have studied genes associated with cardiac function. The present work delves into the results presented previously, with the aim of completing the analysis of the role played by the genetic variants of Apolipoprotein-A1 (APO-A1) in the development of chronic Chagasic cardiomyopathy, in patients from the Province of Córdoba. APO-A1 is the main component of high-density lipoproteins; polymorphisms in this gene have been associated with coronary disease in different populations.
Blood samples from 172 patients (51 men and 121 women) with positive serology for Chagas disease, from the city of Córdoba (Hospital Nacional de Clínicas, Clínica Sucre and Hospital San Roque) were analyzed. The patients were classified as: G1 (n=89): without cardiac alterations, G2 (n=57): with mild cardiac alterations (electrocardiographic alterations), and G3 (n=26): with severe cardiac alterations (electrocardiographic and echocardiographic alterations). APO-A1 G-75A (rs670) and C+83T (rs5069) polymorphisms were determined by PCR-RFLP. Differences between allelic, genotypic and haplotype frequencies were analyzed in relation to the development (G1 vs G2+G3) or progression (G2 vs G3) of Chagasic cardiomyopathy, using chi-square/Fisher's exact test and logistic regression.
Both allele and genotypic frequencies for both polymorphisms were similar among the three groups studied and were not associated with the development or the progression of the cardiomyopathy. No differences were observed between men and women. Exposure to the less frequent allele of each polymorphism was not related to the development [OR rs670_A = 1.24 (0.81-1.9); OR rs5069_T = 1.22 (0.79-1.86)] or with the progression [OR rs670_A = 1.33 (0.69-2.55); OR rs5069_T = 1.55 (0.80-2.98)] of chagasic cardiomyopathy. No differences were found in the frequencies of haplotypes or homozygous/heterozygous between the groups studied.
The results obtained reaffirm what was previously reported (in this case, with a larger number of patients) and suggest that APO-A1 genetic variants would not have a significant contribution in the development of chronic Chagasic cardiomyopathy in the population studied. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2023 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/42647 |
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I10-R327-article-426472023-10-19T21:20:24Z Apolipoprotein-A1 gene variants in the development of chronic chagasic cardiomyopathy Variantes del gen de la Apolipoproteína-A1 en el desarrollo de la miocardiopatía chagásica crónica Velázquez López , DA Gómez, DS Fernández Spector , H Argüello Hoyos, P Blasco , R Bazán, PC Báez , AL Lo Presti, MS APO-A1 polymorphisms chagasic cardiomyopathy association study Polimorfismos de APO-A1 Miocardiopatia chagasica estudio de asociación In recent years, genetic approaches to study the development/progression of Chagasic cardiomyopathy have focused on genes related to the immune response; few have studied genes associated with cardiac function. The present work delves into the results presented previously, with the aim of completing the analysis of the role played by the genetic variants of Apolipoprotein-A1 (APO-A1) in the development of chronic Chagasic cardiomyopathy, in patients from the Province of Córdoba. APO-A1 is the main component of high-density lipoproteins; polymorphisms in this gene have been associated with coronary disease in different populations. Blood samples from 172 patients (51 men and 121 women) with positive serology for Chagas disease, from the city of Córdoba (Hospital Nacional de Clínicas, Clínica Sucre and Hospital San Roque) were analyzed. The patients were classified as: G1 (n=89): without cardiac alterations, G2 (n=57): with mild cardiac alterations (electrocardiographic alterations), and G3 (n=26): with severe cardiac alterations (electrocardiographic and echocardiographic alterations). APO-A1 G-75A (rs670) and C+83T (rs5069) polymorphisms were determined by PCR-RFLP. Differences between allelic, genotypic and haplotype frequencies were analyzed in relation to the development (G1 vs G2+G3) or progression (G2 vs G3) of Chagasic cardiomyopathy, using chi-square/Fisher's exact test and logistic regression. Both allele and genotypic frequencies for both polymorphisms were similar among the three groups studied and were not associated with the development or the progression of the cardiomyopathy. No differences were observed between men and women. Exposure to the less frequent allele of each polymorphism was not related to the development [OR rs670_A = 1.24 (0.81-1.9); OR rs5069_T = 1.22 (0.79-1.86)] or with the progression [OR rs670_A = 1.33 (0.69-2.55); OR rs5069_T = 1.55 (0.80-2.98)] of chagasic cardiomyopathy. No differences were found in the frequencies of haplotypes or homozygous/heterozygous between the groups studied. The results obtained reaffirm what was previously reported (in this case, with a larger number of patients) and suggest that APO-A1 genetic variants would not have a significant contribution in the development of chronic Chagasic cardiomyopathy in the population studied. A lo largo de los últimos años, los enfoques genéticos para el estudio del desarrollo/progresión de la miocardiopatía chagásica, se han centrado en genes relacionados a la respuesta inmune; pocos han estudiado genes asociados a la función cardiaca. El presente trabajo profundiza resultados presentados previamente, con el objetivo de completar el análisis del papel que juegan las variantes genéticas de la Apolipoproteína-A1 (APO-A1) en el desarrollo de la miocardiopatía chagásica crónica, en pacientes de la Provincia de Córdoba. APO-A1 es el componente principal de las lipoproteínas de alta densidad; polimorfismos en este gen han sido asociados a enfermedades coronarias en diferentes poblaciones. Se analizaron muestras de sangre de 172 pacientes (51 hombres y 121 mujeres) con serología positiva para Chagas, de la ciudad de Córdoba (Hospital Nacional de Clínicas, Clínica Sucre y Hospital San Roque). Los pacientes se clasificaron en: G1 (n=89): sin cardiopatía, G2 (n=57): con cardiopatía leve (alteraciones electrocardiográficas) y G3 (n=26): con cardiopatía severa (alteraciones electrocardiográficas y ecocardiográficas). Los polimorfismos G–75A (rs670) y C+83T (rs5069) de APO-A1 se determinaron por PCR-RFLP. Las diferencias entre las frecuencias alélicas, genotípicas y de haplotipos se analizaron en relación con el desarrollo (G1 vs G2+G3) o la progresión (G2 vs G3) de la miocardiopatía chagásica, mediante chi cuadrado/test exacto de Fisher y regresión logística. Las frecuencias alélicas y genotípicas para ambos polimorfismos fueron similares entre los 3 grupos estudiados y no se asociaron al desarrollo ni a la progresión de la miocardiopatía. No se observaron diferencias entre hombres y mujeres. La exposición al alelo menos frecuente de cada polimorfismo no se relacionó con el desarrollo [OR rs670_A = 1,24 (0,81-1,9); OR rs5069_T = 1,22 (0,79-1,86)] ni con la progresión [OR rs670_A = 1,33 (0,69-2,55); OR rs5069_T = 1,55 (0,80-2,98)] de la miocardiopatía chagásica. Tampoco se encontraron diferencias en las frecuencias de haplotipos ni de homocigotas/heterocigotas entre los grupos estudiados. Los resultados obtenidos reafirman lo reportado previamente (en este caso, con una mayor cantidad de pacientes) y sugieren que las variantes genéticas de APO-A1 no tendrían un aporte significativo en el desarrollo de la miocardiopatía chagásica crónica en la población estudiada. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2023-10-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/42647 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 80 (2023): Suplemento JIC XXIV Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 80 (2023): Suplemento JIC XXIV Revista da Faculdade de Ciências Médicas de Córdoba; v. 80 (2023): Suplemento JIC XXIV 1853-0605 0014-6722 spa https://revistas.unc.edu.ar/index.php/med/article/view/42647/42852 Derechos de autor 2023 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0 |