Effect of training on bone quality in rats with insulin resistance induce by fluoride consumption
When large amounts of Fluoride are consumed produces insulin resistance, but exercise can reverse insulin resistance in rats, because of a high fluoride uptake by bone tissue. However, bone quality has not been studied in those experiments. Therefore, the aim of this work was to evaluate bone qualit...
| Autores principales: | , , , , |
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| Formato: | Artículo revista |
| Lenguaje: | Inglés |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2024
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| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/42505 |
| Aporte de: |
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I10-R327-article-42505 |
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| record_format |
ojs |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Inglés |
| format |
Artículo revista |
| topic |
Exercise Fluoride bone and bones Insulin resistance ejercicio físico fluoruro Resistencia a la insulina hueso Exercício fluoreto resistência a insulina osso e ossos |
| spellingShingle |
Exercise Fluoride bone and bones Insulin resistance ejercicio físico fluoruro Resistencia a la insulina hueso Exercício fluoreto resistência a insulina osso e ossos Lombarte, Mercedes Fina, Brenda Lorena García, Victoria Inés Lupo, Maela Rigalli, Alfredo Effect of training on bone quality in rats with insulin resistance induce by fluoride consumption |
| topic_facet |
Exercise Fluoride bone and bones Insulin resistance ejercicio físico fluoruro Resistencia a la insulina hueso Exercício fluoreto resistência a insulina osso e ossos |
| author |
Lombarte, Mercedes Fina, Brenda Lorena García, Victoria Inés Lupo, Maela Rigalli, Alfredo |
| author_facet |
Lombarte, Mercedes Fina, Brenda Lorena García, Victoria Inés Lupo, Maela Rigalli, Alfredo |
| author_sort |
Lombarte, Mercedes |
| title |
Effect of training on bone quality in rats with insulin resistance induce by fluoride consumption |
| title_short |
Effect of training on bone quality in rats with insulin resistance induce by fluoride consumption |
| title_full |
Effect of training on bone quality in rats with insulin resistance induce by fluoride consumption |
| title_fullStr |
Effect of training on bone quality in rats with insulin resistance induce by fluoride consumption |
| title_full_unstemmed |
Effect of training on bone quality in rats with insulin resistance induce by fluoride consumption |
| title_sort |
effect of training on bone quality in rats with insulin resistance induce by fluoride consumption |
| description |
When large amounts of Fluoride are consumed produces insulin resistance, but exercise can reverse insulin resistance in rats, because of a high fluoride uptake by bone tissue. However, bone quality has not been studied in those experiments. Therefore, the aim of this work was to evaluate bone quality in rats treated with fluoride when performing exercise. Sprague-Dawley rats were divided into 3 groups (n=6 per group): Control (drinking water without fluoride), Fluoride (drinking water with fluoride 15 mg/L for 30 days) and Exercise (daily running on a treadmill and drinking water with fluoride 15 mg/L for 30 days). Then, bone mineral density, mechanical and histological properties and bone fluoride level were measured. No effect of treatment on any bone parameters were observed. These results indicate that exercise normalizes glucose metabolism in insulin-resistant rats by bone fluoride uptake; however, this increase in bone fluoride does not manifest in bone deterioration. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2024 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/42505 |
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I10-R327-article-425052024-06-28T16:35:38Z Effect of training on bone quality in rats with insulin resistance induce by fluoride consumption Efecto del ejercicio físico sobre la calidad ósea en ratas con resistencia a la insulina inducida por el consumo de fluoruro Efeito do exercício físico na qualidade óssea em ratos com resistência à insulina induzida pelo consumo de fluoreto Lombarte, Mercedes Fina, Brenda Lorena García, Victoria Inés Lupo, Maela Rigalli, Alfredo Exercise Fluoride bone and bones Insulin resistance ejercicio físico fluoruro Resistencia a la insulina hueso Exercício fluoreto resistência a insulina osso e ossos When large amounts of Fluoride are consumed produces insulin resistance, but exercise can reverse insulin resistance in rats, because of a high fluoride uptake by bone tissue. However, bone quality has not been studied in those experiments. Therefore, the aim of this work was to evaluate bone quality in rats treated with fluoride when performing exercise. Sprague-Dawley rats were divided into 3 groups (n=6 per group): Control (drinking water without fluoride), Fluoride (drinking water with fluoride 15 mg/L for 30 days) and Exercise (daily running on a treadmill and drinking water with fluoride 15 mg/L for 30 days). Then, bone mineral density, mechanical and histological properties and bone fluoride level were measured. No effect of treatment on any bone parameters were observed. These results indicate that exercise normalizes glucose metabolism in insulin-resistant rats by bone fluoride uptake; however, this increase in bone fluoride does not manifest in bone deterioration. Cuando se consumen grandes cantidades de fluoruro se produce resistencia a la insulina, pero la realización de ejercicio puede revertir dicho efecto en ratas, debido a una alta absorción de fluoruro por el tejido óseo. Sin embargo, la calidad ósea no ha sido estudiada. Por ello, el objetivo de este trabajo fue evaluar la calidad ósea en ratas tratadas con flúor que realizan ejercicio. Se trabajó con ratas Sprague-Dawley que se dividieron en 3 grupos (n=6 por grupo): Control (recibiron agua sin flúor), Flúor (recibieron agua con flúor 15 mg/L durante 30 días) y Ejercicio (realizaron ejercicio diariamente en cinta ergométrica y recibieron agua con fluoruro 15 mg/L por 30 días). Luego, se midieron la densidad mineral ósea, las propiedades biomecánicas e histológicas y el nivel de fluoruro óseo. No se observó ningún efecto del tratamiento sobre ningún parámetro óseo. Estos resultados indican que el ejercicio normaliza el metabolismo de la glucosa en ratas resistentes a la insulina mediante la captación ósea de fluoruro; sin embargo, este aumento del fluoruro óseo no se manifiesta en deterioro óseo. Quando grandes quantidades de flúor são consumidas ocorre resistência à insulina, mas o exercício pode reverter esse efeito em ratos, devido à alta absorção de flúor pelo tecido ósseo. No entanto, a qualidade óssea não foi estudada. Portanto, o objetivo deste trabalho foi avaliar a qualidade óssea em ratos tratados com flúor que realizam exercício. Trabalhamos com ratos Sprague-Dawley que foram divididos em 3 grupos (n=6 por grupo): Controle (receberam água sem flúor), Flúor (receberam água com 15 mg/L de flúor por 30 dias) e Exercício (eles se exercitaram diariamente em esteira e recebeu água com flúor 15 mg/L por 30 dias). Em seguida, foram medidas a densidade mineral óssea, as propriedades biomecânicas e histológicas e o nível de flúor ósseo. Nenhum efeito do tratamento foi observado em quaisquer parâmetros ósseos. Estes resultados indicam que o exercício normaliza o metabolismo da glicose em ratos resistentes à insulina através da captação óssea de flúor; entretanto, esse aumento no flúor ósseo não se manifesta na deterioração óssea. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2024-06-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion text/html application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/42505 10.31053/1853.0605.v81.n2.42505 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 81 No. 2 (2024); 270-284 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 81 Núm. 2 (2024); 270-284 Revista da Faculdade de Ciências Médicas de Córdoba; v. 81 n. 2 (2024); 270-284 1853-0605 0014-6722 10.31053/1853.0605.v81.n2 eng https://revistas.unc.edu.ar/index.php/med/article/view/42505/45440 https://revistas.unc.edu.ar/index.php/med/article/view/42505/45443 Derechos de autor 2024 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0 |