Role of superoxide dismutase and fibrinogen in patients with cognitive impairment and depressive symptoms
Among patients with neurocognitive disorder (NCD), depressive symptoms have a high frequency of presentation. Inflammation and oxidative stress play a fundamental role in the initiation and development of the pathophysiology of NCD. Fibrinogen is a recognized inflammatory marker, while superoxide di...
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| Formato: | Artículo revista |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2022
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/39159 |
| Aporte de: |
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I10-R327-article-39159 |
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Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| format |
Artículo revista |
| topic |
neurocogntive disorder inflammation depression trastorno neurocognitivo inflamación depresión |
| spellingShingle |
neurocogntive disorder inflammation depression trastorno neurocognitivo inflamación depresión Castillo, TA Barbero, I Rossi, MM Galetto, CA Müller Gudiño, SE Díaz Bravo, H Báez, MC Scribano Parada , MP Role of superoxide dismutase and fibrinogen in patients with cognitive impairment and depressive symptoms |
| topic_facet |
neurocogntive disorder inflammation depression trastorno neurocognitivo inflamación depresión |
| author |
Castillo, TA Barbero, I Rossi, MM Galetto, CA Müller Gudiño, SE Díaz Bravo, H Báez, MC Scribano Parada , MP |
| author_facet |
Castillo, TA Barbero, I Rossi, MM Galetto, CA Müller Gudiño, SE Díaz Bravo, H Báez, MC Scribano Parada , MP |
| author_sort |
Castillo, TA |
| title |
Role of superoxide dismutase and fibrinogen in patients with cognitive impairment and depressive symptoms |
| title_short |
Role of superoxide dismutase and fibrinogen in patients with cognitive impairment and depressive symptoms |
| title_full |
Role of superoxide dismutase and fibrinogen in patients with cognitive impairment and depressive symptoms |
| title_fullStr |
Role of superoxide dismutase and fibrinogen in patients with cognitive impairment and depressive symptoms |
| title_full_unstemmed |
Role of superoxide dismutase and fibrinogen in patients with cognitive impairment and depressive symptoms |
| title_sort |
role of superoxide dismutase and fibrinogen in patients with cognitive impairment and depressive symptoms |
| description |
Among patients with neurocognitive disorder (NCD), depressive symptoms have a high frequency of presentation. Inflammation and oxidative stress play a fundamental role in the initiation and development of the pathophysiology of NCD. Fibrinogen is a recognized inflammatory marker, while superoxide dismutase stands out among the endogenous antioxidant factors. This work aims to establish the relationship between inflammatory and oxidative stress biomarkers in patients with depressive symptoms and NCD.
The study was an observational prospective analytical cross-sectional study, with patients who attended the consultation spontaneously due to cognitive symptoms and were included after signing informed consent. The Montreal Cognitive Assessment (MoCA) and the Geriatric Depression Scale (GDS) were used as screening tests. The levels of fibrinogen (mg/DL) in plasma and superoxide dismutase (SOD) (U/ml) in red blood cell lysate were quantified by spectrophotometry. For biomarkers, a simple linear regression model was used, with biomarkers as the dependent variable and all other variables as independent prognostic factors. A significance level of p<0.05 was established for all cases.
76 patients were studied with a mean age of 68.39 ± 11.86 years, predominantly female, years of schooling were 08.13 ± 04.40. The MoCA test score was below the cut-off point (22.36 ± 06.30). For GDS, the score was 5.70 ± 0.63. Linear regression analysis showed a negative association between the GDS score and MoCA (p= 0.0008), observing that both fibrinogen and SOD increased in the presence of depressive symptoms (p= 0.0322 and p=0.0165).
These results support the evidence in favor of the inflammatory and oxidative stress association linked to depressive symptoms in patients with NCD, opening new therapeutic horizons. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2022 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/39159 |
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I10-R327-article-391592024-04-15T16:14:45Z Role of superoxide dismutase and fibrinogen in patients with cognitive impairment and depressive symptoms Rol de superóxido dismutasa y fibrinógeno en pacientes con deterioro cognitivo y síntomas depresivos Castillo, TA Barbero, I Rossi, MM Galetto, CA Müller Gudiño, SE Díaz Bravo, H Báez, MC Scribano Parada , MP neurocogntive disorder inflammation depression trastorno neurocognitivo inflamación depresión Among patients with neurocognitive disorder (NCD), depressive symptoms have a high frequency of presentation. Inflammation and oxidative stress play a fundamental role in the initiation and development of the pathophysiology of NCD. Fibrinogen is a recognized inflammatory marker, while superoxide dismutase stands out among the endogenous antioxidant factors. This work aims to establish the relationship between inflammatory and oxidative stress biomarkers in patients with depressive symptoms and NCD. The study was an observational prospective analytical cross-sectional study, with patients who attended the consultation spontaneously due to cognitive symptoms and were included after signing informed consent. The Montreal Cognitive Assessment (MoCA) and the Geriatric Depression Scale (GDS) were used as screening tests. The levels of fibrinogen (mg/DL) in plasma and superoxide dismutase (SOD) (U/ml) in red blood cell lysate were quantified by spectrophotometry. For biomarkers, a simple linear regression model was used, with biomarkers as the dependent variable and all other variables as independent prognostic factors. A significance level of p<0.05 was established for all cases. 76 patients were studied with a mean age of 68.39 ± 11.86 years, predominantly female, years of schooling were 08.13 ± 04.40. The MoCA test score was below the cut-off point (22.36 ± 06.30). For GDS, the score was 5.70 ± 0.63. Linear regression analysis showed a negative association between the GDS score and MoCA (p= 0.0008), observing that both fibrinogen and SOD increased in the presence of depressive symptoms (p= 0.0322 and p=0.0165). These results support the evidence in favor of the inflammatory and oxidative stress association linked to depressive symptoms in patients with NCD, opening new therapeutic horizons. Entre los pacientes con trastorno neurocognitivo (TNC) los síntomas depresivos tienen una alta frecuencia de presentación. La inflamación y el estrés oxidativo juegan un papel fundamental en el inicio y desarrollo de la fisiopatología del TNC. En la actualidad el fibrinógeno es un reconocido marcador inflamatorio, mientras que la superóxido dismutasa se destaca dentro de los factores antioxidantes endógenos. El objetivo del presente trabajo es establecer la relación entre biomarcadores inflamatorios y de estrés oxidativo en pacientes con síntomas depresivos y TNC. El estudio fue observacional prospectivo analítico de corte transversal, con pacientes que asistieron a la consulta por demanda espontanea por síntomas cognitivo, y fueron incluidos previa firma de consentimiento informado. Como pruebas de tamizaje se utilizaron la Evaluación Cognitiva de Montreal (Montreal Cognitive Assessment, MoCA) y la Escala de Depresión Geriátrica (Geriatric Depression Scale, GDS). Se cuantificó por espectrofotometría en plasma fibrinógeno (mg/DL) y en lisado de glóbulos rojos superóxido dismutasa (SOD) (U/ml). En los biomarcadores se empleó un modelo de regresión lineal simple, con estos como variable dependiente y todas las otras variables como factores pronósticos independientes. Se estableció un nivel de significación de p<0.05 para todos los casos. Se estudiaron 76 pacientes con una media de edad de 68.39 ± 11.86 años, predominando el sexo femenino, los años de escolaridad fueron 08.13± 04.40. El puntaje de la prueba MoCA tuvo una media por debajo del punto de corte (22.36 ± 06.30). Para GDS, el puntaje fue de 5,70 ± 0,63. El análisis de regresión lineal demostró una asociación negativa entre el puntaje de GDS y MoCA (p= 0.0008), observándose que tanto fibrinógeno como SOD aumentaban en presencia de síntomas depresivos (p= 0.0322 y p=0.0165). Estos resultados apoyan la evidencia a favor de la asociación inflamatoria y de estrés oxidativo que se vinculan con síntomas depresivos en pacientes con TNC abriendo nuevos horizontes terapéuticos. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2022-10-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto texto texto https://revistas.unc.edu.ar/index.php/med/article/view/39159 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 79 No. Suplemento JIC XXIII (2022): Suplemento JIC XXIII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 79 Núm. Suplemento JIC XXIII (2022): Suplemento JIC XXIII Revista da Faculdade de Ciências Médicas de Córdoba; v. 79 n. Suplemento JIC XXIII (2022): Suplemento JIC XXIII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0 |