Detection of Parvovirus B19 in suspected cases of infection during pregnancy: study of pregnant patients and newborns. Cordoba, Argentina/2018-2022.
Parvovirus B19/B19V primary infection in pregnant women can be transmitted to the embryo/fetus and cause anomalies associated with TORCH syndrome. Local knowledge of the infection can help visualize the clinical picture to achieve early diagnosis. The objectives were to identify B19V in suspected ca...
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2022
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/38990 |
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I10-R327-article-38990 |
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| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| format |
Artículo revista |
| topic |
parvovirus b19 serology viremia hydrops fetalis abortion parvovirus b19 serología viremia hidropesía fetal aborto . |
| spellingShingle |
parvovirus b19 serology viremia hydrops fetalis abortion parvovirus b19 serología viremia hidropesía fetal aborto . Colazo Salbetti, MB Boggio , G Dicuatro, N Moreno , L Ortiz, E Tenaglia , M Hernández , G Alfaro , J Riberi , I Isa , MB Bertoldi, A Pedranti , M Adamo , MP Detection of Parvovirus B19 in suspected cases of infection during pregnancy: study of pregnant patients and newborns. Cordoba, Argentina/2018-2022. |
| topic_facet |
parvovirus b19 serology viremia hydrops fetalis abortion parvovirus b19 serología viremia hidropesía fetal aborto . |
| author |
Colazo Salbetti, MB Boggio , G Dicuatro, N Moreno , L Ortiz, E Tenaglia , M Hernández , G Alfaro , J Riberi , I Isa , MB Bertoldi, A Pedranti , M Adamo , MP |
| author_facet |
Colazo Salbetti, MB Boggio , G Dicuatro, N Moreno , L Ortiz, E Tenaglia , M Hernández , G Alfaro , J Riberi , I Isa , MB Bertoldi, A Pedranti , M Adamo , MP |
| author_sort |
Colazo Salbetti, MB |
| title |
Detection of Parvovirus B19 in suspected cases of infection during pregnancy: study of pregnant patients and newborns. Cordoba, Argentina/2018-2022. |
| title_short |
Detection of Parvovirus B19 in suspected cases of infection during pregnancy: study of pregnant patients and newborns. Cordoba, Argentina/2018-2022. |
| title_full |
Detection of Parvovirus B19 in suspected cases of infection during pregnancy: study of pregnant patients and newborns. Cordoba, Argentina/2018-2022. |
| title_fullStr |
Detection of Parvovirus B19 in suspected cases of infection during pregnancy: study of pregnant patients and newborns. Cordoba, Argentina/2018-2022. |
| title_full_unstemmed |
Detection of Parvovirus B19 in suspected cases of infection during pregnancy: study of pregnant patients and newborns. Cordoba, Argentina/2018-2022. |
| title_sort |
detection of parvovirus b19 in suspected cases of infection during pregnancy: study of pregnant patients and newborns. cordoba, argentina/2018-2022. |
| description |
Parvovirus B19/B19V primary infection in pregnant women can be transmitted to the embryo/fetus and cause anomalies associated with TORCH syndrome. Local knowledge of the infection can help visualize the clinical picture to achieve early diagnosis. The objectives were to identify B19V in suspected cases of parvoviral infection during pregnancy and to describe the clinical manifestations present in positive cases.
Descriptive, cross-sectional study. Inclusion criteria: pregnant patients with suspected B19V infection (compatible maternal or fetal-neonatal clinical manifestations or with epidemiological link), newborns (NB) of mothers with suspected or confirmed infection and NB with signs/symptoms associated with congenital infection (still present or not at birth), selected according to medical records of the clinical history. Viral DNA (PCR), specific IgM and IgG (ELISA) were determined in serum samples stored at the institution’s biobank. Ethical Committee of participating centers approved the protocol: Clinica Universitaria Reina Fabiola, Hospital Universitario de Maternidad y Neonatología, Clínica Privada Vélez Sársfield (2018-2022).
A total of 242 patients were included (epidemiological weeks/EW 1-52, 171 pregnant women and 71 NB, 60 of them were mother-NB pair). Infection was confirmed in 27/242 (11.1%) cases, the majority (24/27, 88.9%) in pregnant women and 3/27 (11.1%) in NB. In the mother-NB pair group, 9 pregnant women and 2 NB were positive (vertical transmission rate: 22.2%). Epidemiological characteristics of B19V+ cases: mean age of pregnant women 30.1±6.3 years (p=0.45 versus study sample; median 30.5), 96% in EW 15-52 (autumn-spring). Clinical manifestations in pregnant women: maternal anemia 14/24 (58.3%), hydrops fetalis 5/24 (20.8%), abortion 5/24 (20.8%), fetal anemia 2/24 (8.3%), polyhydramnios 1/24 (4.2%), rash and arthralgia 1/24 (4.2%). One NB presented hydrops, another anemia, and one was asymptomatic, born to mother with rash, arthralgia, and anemia). Laboratory markers of infection: 16/27 (59.3%) cases were confirmed by detection of viral DNA (DNA+/IgM-/IgG+).
During the study period, B19V was detected in 11% of the sample, being frequent in symptomatic pregnant women (24/171, 14%), with a rate of transmission to the fetus of 22%. Upon clinical suspicion, the complementary determination of virus and antibodies can improve diagnostic performance. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2022 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/38990 |
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I10-R327-article-389902024-04-15T16:14:45Z Detection of Parvovirus B19 in suspected cases of infection during pregnancy: study of pregnant patients and newborns. Cordoba, Argentina/2018-2022. Detección de Parvovirus B19 en casos sospechosos de infección durante la gestación: estudio de pacientes embarazadas y recién nacidos. Córdoba/2018-2022. . Colazo Salbetti, MB Boggio , G Dicuatro, N Moreno , L Ortiz, E Tenaglia , M Hernández , G Alfaro , J Riberi , I Isa , MB Bertoldi, A Pedranti , M Adamo , MP parvovirus b19 serology viremia hydrops fetalis abortion parvovirus b19 serología viremia hidropesía fetal aborto . Parvovirus B19/B19V primary infection in pregnant women can be transmitted to the embryo/fetus and cause anomalies associated with TORCH syndrome. Local knowledge of the infection can help visualize the clinical picture to achieve early diagnosis. The objectives were to identify B19V in suspected cases of parvoviral infection during pregnancy and to describe the clinical manifestations present in positive cases. Descriptive, cross-sectional study. Inclusion criteria: pregnant patients with suspected B19V infection (compatible maternal or fetal-neonatal clinical manifestations or with epidemiological link), newborns (NB) of mothers with suspected or confirmed infection and NB with signs/symptoms associated with congenital infection (still present or not at birth), selected according to medical records of the clinical history. Viral DNA (PCR), specific IgM and IgG (ELISA) were determined in serum samples stored at the institution’s biobank. Ethical Committee of participating centers approved the protocol: Clinica Universitaria Reina Fabiola, Hospital Universitario de Maternidad y Neonatología, Clínica Privada Vélez Sársfield (2018-2022). A total of 242 patients were included (epidemiological weeks/EW 1-52, 171 pregnant women and 71 NB, 60 of them were mother-NB pair). Infection was confirmed in 27/242 (11.1%) cases, the majority (24/27, 88.9%) in pregnant women and 3/27 (11.1%) in NB. In the mother-NB pair group, 9 pregnant women and 2 NB were positive (vertical transmission rate: 22.2%). Epidemiological characteristics of B19V+ cases: mean age of pregnant women 30.1±6.3 years (p=0.45 versus study sample; median 30.5), 96% in EW 15-52 (autumn-spring). Clinical manifestations in pregnant women: maternal anemia 14/24 (58.3%), hydrops fetalis 5/24 (20.8%), abortion 5/24 (20.8%), fetal anemia 2/24 (8.3%), polyhydramnios 1/24 (4.2%), rash and arthralgia 1/24 (4.2%). One NB presented hydrops, another anemia, and one was asymptomatic, born to mother with rash, arthralgia, and anemia). Laboratory markers of infection: 16/27 (59.3%) cases were confirmed by detection of viral DNA (DNA+/IgM-/IgG+). During the study period, B19V was detected in 11% of the sample, being frequent in symptomatic pregnant women (24/171, 14%), with a rate of transmission to the fetus of 22%. Upon clinical suspicion, the complementary determination of virus and antibodies can improve diagnostic performance. La primoinfección por parvovirus B19/B19V en la embarazada puede transmitirse al embrión/feto y causar manifestaciones clínicas asociadas al síndrome de TORCH. Conocer la infección en nuestro medio puede contribuir a visibilizar su presentación clínica y promover el diagnóstico temprano. Los objetivos fueron identificar B19V en casos sospechosos de infección parvoviral durante la gestación y describir las manifestaciones clínicas presentes en los casos positivos. Estudio descriptivo, transversal. Se incluyeron pacientes embarazadas con sospecha de infección por B19V (manifestaciones clínicas maternas o feto-neonatales compatibles o nexo epidemiológico), RN de madres con infección sospechada o confirmada y RN con signos/síntomas asociables a infección congénita (aún presentes o no al nacer), seleccionados a partir de los datos de la historia clínica. Se determinó ADN viral (PCR), IgM e IgG específicas (ELISA) en muestras de suero recuperadas del biobanco. Protocolo aprobado por los Comités de Ética de los centros participantes: Clínica Universitaria Reina Fabiola, Hospital Universitario de Maternidad y Neonatología, Clínica Privada Vélez Sársfield (2018-2022). Se estudiaron 242 pacientes (semanas epidemiológicas/SE 1-52, 171 embarazadas y 71 RN, de ellos 60 constituían binomio madre-RN), confirmándose la infección en 27/242 (11,1%), la mayoría (24/27, 88,9%) en embarazadas y 3/27 (11,1%) en RN. En el grupo de binomios, fueron positivos 9 embarazadas y 2 RN (tasa de transmisión vertical: 22,2%). Características epidemiológicas de los casos B19V+: edad promedio de las embarazadas 30,1±6,3 años (p=0,45 versus muestra estudiada; mediana 30,5), 96% en las SE 15-52 (otoño-primavera). Manifestaciones marcadoras en embarazadas: anemia materna 14/24 (58,3%), hydrops fetal 5/24 (20,8%), aborto 5/24 (20,8%), anemia fetal 2/24 (8,3%), polihidramnios 1/24 (4,2%), exantema y artralgia 1/24 (4,2%). Un RN presentó hydrops, otro anemia y otro fue asintomático (con antecedente de madre positiva con exantema, artralgia y anemia en la madre). Marcadores laboratoriales de infección: 16/27 (59,3%) casos fueron confirmados por detección de ADN viral (ADN+/IgM-/IgG+). En el período estudiado se detectó B19V en 11% de la muestra, siendo frecuente en embarazadas sintomáticas (24/171, 14%), con una tasa de transmisión al feto de 22%. Ante la sospecha clínica, la determinación complementaria de virus y anticuerpos puede mejorar el rendimiento diagnóstico. . Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2022-10-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto texto . https://revistas.unc.edu.ar/index.php/med/article/view/38990 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 79 No. Suplemento JIC XXIII (2022): Suplemento JIC XXIII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 79 Núm. Suplemento JIC XXIII (2022): Suplemento JIC XXIII Revista da Faculdade de Ciências Médicas de Córdoba; v. 79 n. Suplemento JIC XXIII (2022): Suplemento JIC XXIII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0 |