Estudio de lesiones blancas orales potencialmente malignas
Oral Potentially Malignant Disorders (OPMDs) were first described by the World Health Organization (WHO) as a tissue of disturbed morphology with increased risk of cancerization (higher than 5%). Nowadays, according to Warnakulasuriya, the spectrum of OPMD must also include Oral Lichenoid Lesions. T...
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| Autores principales: | , , , , , , |
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| Formato: | Artículo revista |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/35777 |
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| Sumario: | Oral Potentially Malignant Disorders (OPMDs) were first described by the World Health Organization (WHO) as a tissue of disturbed morphology with increased risk of cancerization (higher than 5%). Nowadays, according to Warnakulasuriya, the spectrum of OPMD must also include Oral Lichenoid Lesions. The aim of the present study was to analyze and compare clinical, histopathological and immunohistochemical features in cases of Oral Lichen Planus (OLP), Oral Lichenoid Lesions (OLL) and Oral Leukoplakia (OL). The research was retrospective, observational and descriptive, carried on biopsies of patients between the years 2015 and 2017 that were taken in at the Laboratory of Pathological Anatomy, diagnosed at Chair of Pathological Anatomy of Faculty of Dentistry, UNC and analyzed at the Laboratory of Molecular Pathology of Faculty of Dentistry, UDELAR. Cases of OLP and OLL were diagnosed following Van der Waal – Van der Meij criteria, and OL following Lanfranchi criteria. Descriptive statistics were used. A total of 27 cases were studied (9 from each pathology), from which 11 were women (OLP:0, OLL: 7 and OL:4) and 16 men (OLP: 9, OLL:2 and OL:5), with an average age of 56 years old (OLP: 58, OLL:55 and OL: 56). Biopsy site selection was: oral jugal mucosa for OLP and OL, while tongue was chosen for OLL. Among the distinguishable histopathological features between these pathologies, we can highlight that parakeratinization was more frequent in OLP and OLL; whereas orthokeratinization in OL. Epithelial acanthosis, papillomatosis and dysplasia were more frequent in OLL and OL. Regarding immunohistochemical expression of p53, all OL cases were positive, whilst in OLP and OLL turned out negative, which was statistically significant p=< 0,0001. In current Oral pathology, it is necessary to classify OLP and OLL using Van der Waal – Van der Meij criteria and to know the distinguishable characteristics of each one of these OPMDs emphasizing in the correct diagnosis of these pathologies, as well as their early diagnosis. |
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