Estudio de lesiones blancas orales potencialmente malignas
Oral Potentially Malignant Disorders (OPMDs) were first described by the World Health Organization (WHO) as a tissue of disturbed morphology with increased risk of cancerization (higher than 5%). Nowadays, according to Warnakulasuriya, the spectrum of OPMD must also include Oral Lichenoid Lesions. T...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Artículo revista |
| Publicado: |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
|
| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/35777 |
| Aporte de: |
| id |
I10-R327-article-35777 |
|---|---|
| record_format |
ojs |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| format |
Artículo revista |
| topic |
oral lichen planus oral lichenoid lesions Oral Leukoplakia immunohistochemistry liquen plano oral lesiones liquenoides orales leucoplasia oral inmunohistoquimica . |
| spellingShingle |
oral lichen planus oral lichenoid lesions Oral Leukoplakia immunohistochemistry liquen plano oral lesiones liquenoides orales leucoplasia oral inmunohistoquimica . Bargas, J Massaia, C Cisneros, MV Robledo, GM Navarro, MS Pereira, V Tomasi, RA Estudio de lesiones blancas orales potencialmente malignas |
| topic_facet |
oral lichen planus oral lichenoid lesions Oral Leukoplakia immunohistochemistry liquen plano oral lesiones liquenoides orales leucoplasia oral inmunohistoquimica . |
| author |
Bargas, J Massaia, C Cisneros, MV Robledo, GM Navarro, MS Pereira, V Tomasi, RA |
| author_facet |
Bargas, J Massaia, C Cisneros, MV Robledo, GM Navarro, MS Pereira, V Tomasi, RA |
| author_sort |
Bargas, J |
| title |
Estudio de lesiones blancas orales potencialmente malignas |
| title_short |
Estudio de lesiones blancas orales potencialmente malignas |
| title_full |
Estudio de lesiones blancas orales potencialmente malignas |
| title_fullStr |
Estudio de lesiones blancas orales potencialmente malignas |
| title_full_unstemmed |
Estudio de lesiones blancas orales potencialmente malignas |
| title_sort |
estudio de lesiones blancas orales potencialmente malignas |
| description |
Oral Potentially Malignant Disorders (OPMDs) were first described by the World Health Organization (WHO) as a tissue of disturbed morphology with increased risk of cancerization (higher than 5%). Nowadays, according to Warnakulasuriya, the spectrum of OPMD must also include Oral Lichenoid Lesions. The aim of the present study was to analyze and compare clinical, histopathological and immunohistochemical features in cases of Oral Lichen Planus (OLP), Oral Lichenoid Lesions (OLL) and Oral Leukoplakia (OL). The research was retrospective, observational and descriptive, carried on biopsies of patients between the years 2015 and 2017 that were taken in at the Laboratory of Pathological Anatomy, diagnosed at Chair of Pathological Anatomy of Faculty of Dentistry, UNC and analyzed at the Laboratory of Molecular Pathology of Faculty of Dentistry, UDELAR. Cases of OLP and OLL were diagnosed following Van der Waal – Van der Meij criteria, and OL following Lanfranchi criteria. Descriptive statistics were used. A total of 27 cases were studied (9 from each pathology), from which 11 were women (OLP:0, OLL: 7 and OL:4) and 16 men (OLP: 9, OLL:2 and OL:5), with an average age of 56 years old (OLP: 58, OLL:55 and OL: 56). Biopsy site selection was: oral jugal mucosa for OLP and OL, while tongue was chosen for OLL. Among the distinguishable histopathological features between these pathologies, we can highlight that parakeratinization was more frequent in OLP and OLL; whereas orthokeratinization in OL. Epithelial acanthosis, papillomatosis and dysplasia were more frequent in OLL and OL. Regarding immunohistochemical expression of p53, all OL cases were positive, whilst in OLP and OLL turned out negative, which was statistically significant p=< 0,0001. In current Oral pathology, it is necessary to classify OLP and OLL using Van der Waal – Van der Meij criteria and to know the distinguishable characteristics of each one of these OPMDs emphasizing in the correct diagnosis of these pathologies, as well as their early diagnosis. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/35777 |
| work_keys_str_mv |
AT bargasj estudiodelesionesblancasoralespotencialmentemalignas AT massaiac estudiodelesionesblancasoralespotencialmentemalignas AT cisnerosmv estudiodelesionesblancasoralespotencialmentemalignas AT robledogm estudiodelesionesblancasoralespotencialmentemalignas AT navarroms estudiodelesionesblancasoralespotencialmentemalignas AT pereirav estudiodelesionesblancasoralespotencialmentemalignas AT tomasira estudiodelesionesblancasoralespotencialmentemalignas |
| first_indexed |
2024-09-03T21:03:17Z |
| last_indexed |
2024-09-03T21:03:17Z |
| _version_ |
1809210301638246400 |
| spelling |
I10-R327-article-357772024-04-15T16:19:09Z Estudio de lesiones blancas orales potencialmente malignas Estudio de lesiones blancas orales potencialmente malignas Estudio de lesiones blancas orales potencialmente malignas Bargas, J Massaia, C Cisneros, MV Robledo, GM Navarro, MS Pereira, V Tomasi, RA oral lichen planus oral lichenoid lesions Oral Leukoplakia immunohistochemistry liquen plano oral lesiones liquenoides orales leucoplasia oral inmunohistoquimica . Oral Potentially Malignant Disorders (OPMDs) were first described by the World Health Organization (WHO) as a tissue of disturbed morphology with increased risk of cancerization (higher than 5%). Nowadays, according to Warnakulasuriya, the spectrum of OPMD must also include Oral Lichenoid Lesions. The aim of the present study was to analyze and compare clinical, histopathological and immunohistochemical features in cases of Oral Lichen Planus (OLP), Oral Lichenoid Lesions (OLL) and Oral Leukoplakia (OL). The research was retrospective, observational and descriptive, carried on biopsies of patients between the years 2015 and 2017 that were taken in at the Laboratory of Pathological Anatomy, diagnosed at Chair of Pathological Anatomy of Faculty of Dentistry, UNC and analyzed at the Laboratory of Molecular Pathology of Faculty of Dentistry, UDELAR. Cases of OLP and OLL were diagnosed following Van der Waal – Van der Meij criteria, and OL following Lanfranchi criteria. Descriptive statistics were used. A total of 27 cases were studied (9 from each pathology), from which 11 were women (OLP:0, OLL: 7 and OL:4) and 16 men (OLP: 9, OLL:2 and OL:5), with an average age of 56 years old (OLP: 58, OLL:55 and OL: 56). Biopsy site selection was: oral jugal mucosa for OLP and OL, while tongue was chosen for OLL. Among the distinguishable histopathological features between these pathologies, we can highlight that parakeratinization was more frequent in OLP and OLL; whereas orthokeratinization in OL. Epithelial acanthosis, papillomatosis and dysplasia were more frequent in OLL and OL. Regarding immunohistochemical expression of p53, all OL cases were positive, whilst in OLP and OLL turned out negative, which was statistically significant p=< 0,0001. In current Oral pathology, it is necessary to classify OLP and OLL using Van der Waal – Van der Meij criteria and to know the distinguishable characteristics of each one of these OPMDs emphasizing in the correct diagnosis of these pathologies, as well as their early diagnosis. Los Trastornos Potencialmente Malignos Orales (TPMO) fueron descriptos por la Organización Mundial de la Salud (OMS) como aquel tejido de morfología alterada con mayor predisposición a la cancerización (superior al 5%). Actualmente, para Warnakulasuriya, el espectro de TPMO debe incluir además a las reacciones liquenoides orales. El objetivo del presente estudio fue analizar y comparar las características clínicas, histopatológicas e inmunohistoquímicas en casos de Liquen Plano Oral (LPO), Lesiones Liquenoides Orales (LLO) y Leucoplasia Oral (LO). El estudio fue de tipo retrospectivo, observacional y descriptivo en biopsias de pacientes,entre los años 2015 a 2017, recibidas en el Laboratorio de Anatomía Patológica, diagnosticadas en la cátedra de Anatomía Patológica de la Facultad de Odontología de la UNC y analizadas en el Laboratorio de Patología Molecular de la Facultad de Odontología de la UDELAR. Los casos de LPO y LLO se diagnosticaron con criterios de Van der Waal-Van der Meij (VW-VM),y las LO mediante los criterios de Lanfranchi. Se utilizó estadística descriptiva. Se estudiaron 27 casos (9 de cada patología), de las cuales fueron 11 mujeres (LPO:0, LLO:7 y LO:4) y 16 varones (LPO: 9 LLO:2 y LO:5) con una edad media de 56 años (LPO:58,LLO:55 y LO:56). El sitio de toma de biopsia fue: mucosa yugal para LPO y LO mientras que para LLO fue la lengua. Dentro de las características histopatológicos diferenciables entre estas patologías se puede destacar que la paraqueratinización fue más frecuente en LPO y LLO mientras que la ortoqueratinización en LO. La acantosis, papilomatosis y displasia epitelial fueron más frecuentes en LLO y LO. En relación con la expresión inmunohistoquímica de p53, todos los casos de LO fueron positivos mientras que en el LPO y LLO fueron negativos; lo que fue estadísticamente significativo p=< 0,0001. En la patología oral actual, es necesario clasificar al LPO y LLO utilizando los criterios de Van der Waal-Van der Meij y conocer las características diferenciales de cada uno de estos TPMO poniendo énfasis en el correcto diagnóstico de estas patologías aśi como en el diagnóstico precoz de las mismas. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-10-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto https://revistas.unc.edu.ar/index.php/med/article/view/35777 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. Suplemento (2021): Suplemento JIC XXII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. Suplemento (2021): Suplemento JIC XXII Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. Suplemento (2021): Suplemento JIC XXII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0 |