Lipid Profile In Psoriatic Arthritis. Frequency And Association With Disease Activity

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Abstract:  Introduction: Psoriatic Arthritis (PsA) is associated with increased risk of Obesity, Insulin Resistance, Metabolic Syndrome (MetS), Arterial Hypertension (AHT), Dyslipidemia, and Cardiovascular Disease compared to the general population.  The lipid profile in these...

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Autores principales: Tissera , YS, Savio , V, Quaglia , MI, Neme , V, Demarchi , M, Gobbi , C, Albiero, JA, Alba , PB
Formato: Artículo revista
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021
Materias:
hypertriglyceridemia
psoriatic arthritis
Hipertrigliceridemia
Artritis psoriasica
.
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/35052
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
id I10-R327-article-35052
record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
format Artículo revista
topic hypertriglyceridemia
psoriatic arthritis
Hipertrigliceridemia
Artritis psoriasica
.
spellingShingle hypertriglyceridemia
psoriatic arthritis
Hipertrigliceridemia
Artritis psoriasica
.
Tissera , YS
Savio , V
Quaglia , MI
Neme , V
Demarchi , M
Gobbi , C
Albiero, JA
Alba , PB
Lipid Profile In Psoriatic Arthritis. Frequency And Association With Disease Activity
topic_facet hypertriglyceridemia
psoriatic arthritis
Hipertrigliceridemia
Artritis psoriasica
.
author Tissera , YS
Savio , V
Quaglia , MI
Neme , V
Demarchi , M
Gobbi , C
Albiero, JA
Alba , PB
author_facet Tissera , YS
Savio , V
Quaglia , MI
Neme , V
Demarchi , M
Gobbi , C
Albiero, JA
Alba , PB
author_sort Tissera , YS
title Lipid Profile In Psoriatic Arthritis. Frequency And Association With Disease Activity
title_short Lipid Profile In Psoriatic Arthritis. Frequency And Association With Disease Activity
title_full Lipid Profile In Psoriatic Arthritis. Frequency And Association With Disease Activity
title_fullStr Lipid Profile In Psoriatic Arthritis. Frequency And Association With Disease Activity
title_full_unstemmed Lipid Profile In Psoriatic Arthritis. Frequency And Association With Disease Activity
title_sort lipid profile in psoriatic arthritis. frequency and association with disease activity
description Abstract:  Introduction: Psoriatic Arthritis (PsA) is associated with increased risk of Obesity, Insulin Resistance, Metabolic Syndrome (MetS), Arterial Hypertension (AHT), Dyslipidemia, and Cardiovascular Disease compared to the general population.  The lipid profile in these patients has been studied for a long time, however, the results on this association remain controversial.  Objectives: To study the frequency of altered lipid profiles in patients with Psoriatic arthritis (PsA) and its association with disease activity.   Methods: We studied all the patients diagnosed with PsA who consecutively attended to Rheumatology Unit at Cordoba Hospital from July 2018 to December 2019. Psa was diagnosed according to CASPAR criteria.  Clinical, and laboratory data were collected. The activity of the disease was evaluated by PASI, MDA and DAPSA. p < 0.05 was considered statistically significant.  Results: 42 PsA patients were included. Mean age was 56 years old (47,25-62,75) and 54.76% were female (n=23). 92.86% (n =39) of the patients had plaque Psoriasis. The predominant joint involvement was peripheral and polyarticular (87.8%), the median time since diagnosis was 17 months (12-89). Seventy-six percent were receiving methotrexate and 40% biologics. Disease activity measured by DAPSA was predominantly moderate in 17 patients. The median laboratory values found: total cholesterol 194.5 mg/dl (164.8-218.2), triglycerides 139.50 mg/dl (89.25-191.20) and ApoB/ApoA ratio 0.63 (0.42-0.81). Fifty-seven percent of the patients had an altered lipid profile, with hypertriglyceridemia being the most frequent (48%). There was no correlation between Apo B/Apo A Ratio with DAPSA (rho=0.013; p=0.9396) nor with MDA (rho=-0.029; p=0.8671). Conclusion: In spite of the presence of cardiovascular factors in the majority of PsA patients, lipid profile is not associated with disease activity in this population. However, the presence of hypertriglyceridemia was a characteristic finding in these patients.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2021
url https://revistas.unc.edu.ar/index.php/med/article/view/35052
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spelling I10-R327-article-350522024-04-15T16:19:09Z Lipid Profile In Psoriatic Arthritis. Frequency And Association With Disease Activity Perfil lipídico en pacientes con Artritis Psoriásica. Análisis en una cohorte de Espondiloartritis A Tissera , YS Savio , V Quaglia , MI Neme , V Demarchi , M Gobbi , C Albiero, JA Alba , PB hypertriglyceridemia psoriatic arthritis Hipertrigliceridemia Artritis psoriasica . Abstract:  Introduction: Psoriatic Arthritis (PsA) is associated with increased risk of Obesity, Insulin Resistance, Metabolic Syndrome (MetS), Arterial Hypertension (AHT), Dyslipidemia, and Cardiovascular Disease compared to the general population.  The lipid profile in these patients has been studied for a long time, however, the results on this association remain controversial.  Objectives: To study the frequency of altered lipid profiles in patients with Psoriatic arthritis (PsA) and its association with disease activity.   Methods: We studied all the patients diagnosed with PsA who consecutively attended to Rheumatology Unit at Cordoba Hospital from July 2018 to December 2019. Psa was diagnosed according to CASPAR criteria.  Clinical, and laboratory data were collected. The activity of the disease was evaluated by PASI, MDA and DAPSA. p < 0.05 was considered statistically significant.  Results: 42 PsA patients were included. Mean age was 56 years old (47,25-62,75) and 54.76% were female (n=23). 92.86% (n =39) of the patients had plaque Psoriasis. The predominant joint involvement was peripheral and polyarticular (87.8%), the median time since diagnosis was 17 months (12-89). Seventy-six percent were receiving methotrexate and 40% biologics. Disease activity measured by DAPSA was predominantly moderate in 17 patients. The median laboratory values found: total cholesterol 194.5 mg/dl (164.8-218.2), triglycerides 139.50 mg/dl (89.25-191.20) and ApoB/ApoA ratio 0.63 (0.42-0.81). Fifty-seven percent of the patients had an altered lipid profile, with hypertriglyceridemia being the most frequent (48%). There was no correlation between Apo B/Apo A Ratio with DAPSA (rho=0.013; p=0.9396) nor with MDA (rho=-0.029; p=0.8671). Conclusion: In spite of the presence of cardiovascular factors in the majority of PsA patients, lipid profile is not associated with disease activity in this population. However, the presence of hypertriglyceridemia was a characteristic finding in these patients. Resumen:  Introducción: La Artritis Psoriásica (APS) se asocia con mayor riesgo de Obesidad, Insulinorresistencia, Síndrome Metabólico (SMet), Hipertensión arterial (HTA),  Dislipemia y Enfermedad Cardiovascular comparado con la población general.  El perfil lipídico en estos pacientes ha sido estudiado durante mucho tiempo, sin embargo, los resultados sobre esta asociación permanecen controversiales.  Objetivo: Evaluar la frecuencia de alteraciones del perfil lipídico en pacientes con APS, y su posible asociación con la actividad de la enfermedad.  Materiales y métodos: Estudio transversal, realizado en una clínica de Espondiloartritis. Se incluyeron pacientes con APS según criterios de CASPAR, evaluados consecutivamente desde Julio a Diciembre del 2019. Se analizaron características demográficas, comorbilidades. Las variables analizadas fueron tratamiento, tiempo evolutivo, compromiso articular, talla, peso, perímetro abdominal e índice de masa corporal (IMC), actividad de la enfermedad por PASI, MDA y DAPSA. Se recolectaron muestras sanguíneas con ayunas de 12 horas para análisis químicos.  Variables cuantitativas expresadas en mediana y 1er y 3er intercuartil; variables cualitativas expresadas en frecuencia y porcentaje. RESULTADOS: 42 pacientes fueron evaluados, con una mediana de edad de 56 años (47,25-62,75), 23 mujeres (54,76%). 39 (92,86%) presentaban Psoriasis en placa. El compromiso articular predominante fue periférico y poliarticular (87,8%), la mediana desde el diagnóstico fue de 17 meses (12-89). El 76% recibían Metotrexato y el 40% biológicos. La comorbilidad más frecuente hallada fue SMet en 64,3%, seguido de obesidad 52,8%.La actividad de la enfermedad medida por DAPSA fue predominantemente moderada en 17 pacientes. Las medianas de valores de laboratorio hallados: colesterol total 194,5 mg/dl (164,8-218,2) , triglicéridos 139,50 mg/dl (89,25-191,20) y cociente ApoB/ApoA 0,63 (0,42-0,81). Un 57% de los pacientes tenían perfil lipídico alterado, siendo la hipertrigliceridemia la más frecuente (48%). No hubo correlación entre el Cociente Apo B/Apo A con DAPSA (rho=0,013; p=0.9396) ni con MDA (rho=-0,029; p=0.8671). Conclusiones: En esta cohorte no se encontró  relación entre el perfil lipídico y la actividad de la Artritis Psoriásica. Sin embargo, la hipertrigliceridemia fue un hallazgo característico de estos pacientes. . Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-10-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto texto texto https://revistas.unc.edu.ar/index.php/med/article/view/35052 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. Suplemento (2021): Suplemento JIC XXII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. Suplemento (2021): Suplemento JIC XXII Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. Suplemento (2021): Suplemento JIC XXII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0

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