Pulmonary innate immune response in Sars-cov-2 infection

Introduction: The emerging infection caused by the new SARS-CoV-2 coronavirus has become a real challenge for the scientific community. Currently, there is little knowledge about the pathogenesis of COVID-19 and in recent times the participation of the host's own immune response in the progress...

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Autores principales: Bottino, Emanuel, Ponce, Andrés Alberto
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2022
Materias:
coronavirus
covid-19
immunity innate
inmunidad innata
imunidade inata
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/30642
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
id I10-R327-article-30642
record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Español
format Artículo revista
topic coronavirus
covid-19
immunity innate
coronavirus
covid-19
inmunidad innata
coronavirus
covid-19
imunidade inata
spellingShingle coronavirus
covid-19
immunity innate
coronavirus
covid-19
inmunidad innata
coronavirus
covid-19
imunidade inata
Bottino, Emanuel
Ponce, Andrés Alberto
Pulmonary innate immune response in Sars-cov-2 infection
topic_facet coronavirus
covid-19
immunity innate
coronavirus
covid-19
inmunidad innata
coronavirus
covid-19
imunidade inata
author Bottino, Emanuel
Ponce, Andrés Alberto
author_facet Bottino, Emanuel
Ponce, Andrés Alberto
author_sort Bottino, Emanuel
title Pulmonary innate immune response in Sars-cov-2 infection
title_short Pulmonary innate immune response in Sars-cov-2 infection
title_full Pulmonary innate immune response in Sars-cov-2 infection
title_fullStr Pulmonary innate immune response in Sars-cov-2 infection
title_full_unstemmed Pulmonary innate immune response in Sars-cov-2 infection
title_sort pulmonary innate immune response in sars-cov-2 infection
description Introduction: The emerging infection caused by the new SARS-CoV-2 coronavirus has become a real challenge for the scientific community. Currently, there is little knowledge about the pathogenesis of COVID-19 and in recent times the participation of the host's own immune response in the progression of the disease has been proposed. Innate pulmonary immunity is the first barrier against different toxins, which can cause tissue damage, with the consequent alteration of respiratory function. However, a loss in the regulation of these inflammatory mechanisms can cause a disruption in the homeostasis of the affected tissue. Objective: To evaluate the role of the pulmonary innate immune response in the pathogenesis of COVID-19. Materials and methods: A systematic review of studies published in scientific search engines was carried out: PubMed, Google Scholar, Science Direct. The following keywords were used: “COVID-19”; "Acute Respiratory Distress Syndrome"; "SARS-CoV-2"; "Innate pulmonary immunity"; "Innate immune response". Results: A global alteration of the pulmonary innate immune response was found in SARS-CoV-2 infection, which would have relevance in the pathogenesis of COVID-19. Conclusion: The global involvement of the innate immune response and consequently of lung tissue homeostasis, in SARS-CoV-2 infection, requires the design of new therapeutic strategies aimed at modulating the altered pro-inflammatory mechanisms in COVID-19.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2022
url https://revistas.unc.edu.ar/index.php/med/article/view/30642
work_keys_str_mv AT bottinoemanuel pulmonaryinnateimmuneresponseinsarscov2infection
AT ponceandresalberto pulmonaryinnateimmuneresponseinsarscov2infection
AT bottinoemanuel respuestainmunitariainnatapulmonarenlainfeccionporsarscov2
AT ponceandresalberto respuestainmunitariainnatapulmonarenlainfeccionporsarscov2
AT bottinoemanuel respostaimuneinatapulmonarnainfeccaoporsarscov2
AT ponceandresalberto respostaimuneinatapulmonarnainfeccaoporsarscov2
first_indexed 2024-09-03T21:02:08Z
last_indexed 2024-09-03T21:02:08Z
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spelling I10-R327-article-306422022-06-06T11:18:17Z Pulmonary innate immune response in Sars-cov-2 infection Respuesta inmunitaria innata pulmonar en la infección por Sars-Cov-2 Resposta imune inata pulmonar na infecção por Sars-cov-2 Bottino, Emanuel Ponce, Andrés Alberto coronavirus covid-19 immunity innate coronavirus covid-19 inmunidad innata coronavirus covid-19 imunidade inata Introduction: The emerging infection caused by the new SARS-CoV-2 coronavirus has become a real challenge for the scientific community. Currently, there is little knowledge about the pathogenesis of COVID-19 and in recent times the participation of the host's own immune response in the progression of the disease has been proposed. Innate pulmonary immunity is the first barrier against different toxins, which can cause tissue damage, with the consequent alteration of respiratory function. However, a loss in the regulation of these inflammatory mechanisms can cause a disruption in the homeostasis of the affected tissue. Objective: To evaluate the role of the pulmonary innate immune response in the pathogenesis of COVID-19. Materials and methods: A systematic review of studies published in scientific search engines was carried out: PubMed, Google Scholar, Science Direct. The following keywords were used: “COVID-19”; "Acute Respiratory Distress Syndrome"; "SARS-CoV-2"; "Innate pulmonary immunity"; "Innate immune response". Results: A global alteration of the pulmonary innate immune response was found in SARS-CoV-2 infection, which would have relevance in the pathogenesis of COVID-19. Conclusion: The global involvement of the innate immune response and consequently of lung tissue homeostasis, in SARS-CoV-2 infection, requires the design of new therapeutic strategies aimed at modulating the altered pro-inflammatory mechanisms in COVID-19. Introducción: La infección emergente producida por el nuevo coronavirus SARS-CoV-2, se ha constituido en un verdadero desafío para la comunidad científica. Actualmente, es escaso el conocimiento acerca de la patogenia de COVID-19 y en el último tiempo, se ha propuesto la participación de la respuesta inmunitaria propia del huésped, en la progresión de la enfermedad. La inmunidad innata pulmonar se constituye como la primera barrera ante diferentes noxas, que puedan provocar lesión tisular, con la consiguiente alteración de la función respiratoria. Sin embargo, una pérdida en la regulación de estos mecanismos inflamatorios puede provocar una disrupción en la homeostasis del tejido afectado. Objetivo: Evaluar el papel de la respuesta inmune innata pulmonar en la patogenia de COVID-19. Materiales y métodos: Se realizó una revisión sistemática de estudios publicados en buscadores científicos: PubMed, Google Scholar, Science Direct. Se utilizaron las siguientes palabras claves: “COVID-19”; “Acute Respiratory Distress Syndrome”; “SARS-CoV-2”; “Innate pulmonary immunity”; “innate immune response”. Resultados: Se encontró una alteración global de la respuesta inmune innata pulmonar en la infección por SARS-CoV-2, que tendría relevancia en la patogenia de COVID-19. Conclusión: La afectación global de la respuesta inmune innata y por consiguiente de la homeostasis tisular pulmonar, en la infección por SARS-CoV-2, requiere el diseño de nuevas estrategias terapéuticas destinadas a la modulación de los mecanismos pro inflamatorios alterados en COVID-19. Introdução: A infecção emergente causada pelo novo coronavírus SARS-CoV-2 tornou-se um verdadeiro desafio para a comunidade científica. Atualmente, há pouco conhecimento sobre a patogênese da COVID-19 e recentemente foi proposta a participação da resposta imune do próprio hospedeiro na progressão da doença. A imunidade pulmonar inata é a primeira barreira contra diferentes toxinas, que podem causar danos aos tecidos, com a conseqüente alteração da função respiratória. No entanto, uma perda na regulação desses mecanismos inflamatórios pode causar uma alteração na homeostase do tecido afetado. Objetivo: Avaliar o papel da resposta imune pulmonar inata na patogênese da COVID-19. Materiais e métodos: Foi realizada uma revisão sistemática de estudos publicados em buscadores científicos: PubMed, Google Scholar, Science Direct. Foram utilizadas as seguintes palavras-chave: “COVID-19”; "Acute Respiratory Distress Syndrome"; "SARS-CoV-2"; "Innate pulmonary immunity"; "Innate immune response". Resultados: Foi encontrada uma alteração global na resposta imune pulmonar inata na infecção por SARS-CoV-2, que seria relevante na patogênese do COVID-19. Conclusão: O envolvimento global da resposta imune inata e, conseqüentemente, da homeostase do tecido pulmonar, na infecção por SARS-CoV-2, requer o desenho de novas estratégias terapêuticas destinadas a modular os mecanismos pró-inflamatórios alterados em COVID-19. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2022-03-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion text/html application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/30642 10.31053/1853.0605.v79.n1.30642 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 79 No. 1 (2022); 33-42 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 79 Núm. 1 (2022); 33-42 Revista da Faculdade de Ciências Médicas de Córdoba; v. 79 n. 1 (2022); 33-42 1853-0605 0014-6722 10.31053/1853.0605.v79.n1 spa https://revistas.unc.edu.ar/index.php/med/article/view/30642/37143 https://revistas.unc.edu.ar/index.php/med/article/view/30642/37251 Derechos de autor 2022 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0

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