Saliva immune-inflammatory response in pregnant women with periodontitis

Periodontitis Disease is associated with the colonization on the surface of the teeth and the gingival groove of Gram-negative anaerobic bacteria, forming a reservoir of microorganisms, endotoxins and mediators of inflammation, which often enter onto the general circulation and could produce a state...

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Autores principales: Solari, N, Tabares, S, Ravasi, C, Oddo, S, Bertacín, T, Rosella, AC, Usin, MM, Sembaj, A
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2019
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/25831
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
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institution Universidad Nacional de Córdoba
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container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Español
format Artículo revista
author Solari, N
Tabares, S
Ravasi, C
Oddo, S
Bertacín, T
Rosella, AC
Usin, MM
Sembaj, A
spellingShingle Solari, N
Tabares, S
Ravasi, C
Oddo, S
Bertacín, T
Rosella, AC
Usin, MM
Sembaj, A
Saliva immune-inflammatory response in pregnant women with periodontitis
author_facet Solari, N
Tabares, S
Ravasi, C
Oddo, S
Bertacín, T
Rosella, AC
Usin, MM
Sembaj, A
author_sort Solari, N
title Saliva immune-inflammatory response in pregnant women with periodontitis
title_short Saliva immune-inflammatory response in pregnant women with periodontitis
title_full Saliva immune-inflammatory response in pregnant women with periodontitis
title_fullStr Saliva immune-inflammatory response in pregnant women with periodontitis
title_full_unstemmed Saliva immune-inflammatory response in pregnant women with periodontitis
title_sort saliva immune-inflammatory response in pregnant women with periodontitis
description Periodontitis Disease is associated with the colonization on the surface of the teeth and the gingival groove of Gram-negative anaerobic bacteria, forming a reservoir of microorganisms, endotoxins and mediators of inflammation, which often enter onto the general circulation and could produce a state Chronic inflammatory, capable of affecting pregnancy producing a more exacerbated clinical manifestation. The objective was to evaluate the capacity of saliva immune inflammatory response in pregnant women with periodontitis who voluntarily attend to the Dentistry Service of the Provincial Maternity. 100 pregnant and 50 non-pregnant women who signed the consent to participate in the project (REPIS Registry 3065/16) were studied. All periodontal parameters were evaluated. From each sextant, samples were taken from the deepest pocket for microbiological identification by molecular biology. Samples of unstimulated saliva were taken to determine the concentration of IgA and IgG, Reactive Protein C (PCR), Myeloperoxidase (MPO) and Nitrite Concentration. Data were analyzed with the χ2 test, Fisher, T test as appropriate, a p <of 0.05 was considered significant. It was analyzed with Infostat 2018 / p software. T.denticola was identified as the most frequent bacteria in pregnant women in addition to P.intermedia (p=0.0177). The concentration of Ig A is higher in pregnant women compared to non-pregnant women (p=0.0204). The presence of P.gingivalis+T.denticola+ T.forsythia was significantly associated with high concentrations of IgA in pregnant women (p=0.03). A RR=7,95% CI (3.27-16.4) was calculated. While nitrite concentration and MOP activity was significantly lower in pregnant women. The data suggest that pregnant women are 7 times more likely to developed clinical insertion greater than or equal to 3mm and pocket deepest than 4mm when the P.gingivalis + T.denticola + T.forsythia triad is present. Elevated levels of IgA in saliva would indicate a positive response capacity of the host against red complex bacteria
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2019
url https://revistas.unc.edu.ar/index.php/med/article/view/25831
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spelling I10-R327-article-258312024-08-27T18:26:27Z Saliva immune-inflammatory response in pregnant women with periodontitis Respuesta inmune-inflamatoria salival en embarazadas con periodontitis Solari, N Tabares, S Ravasi, C Oddo, S Bertacín, T Rosella, AC Usin, MM Sembaj, A Periodontitis Disease is associated with the colonization on the surface of the teeth and the gingival groove of Gram-negative anaerobic bacteria, forming a reservoir of microorganisms, endotoxins and mediators of inflammation, which often enter onto the general circulation and could produce a state Chronic inflammatory, capable of affecting pregnancy producing a more exacerbated clinical manifestation. The objective was to evaluate the capacity of saliva immune inflammatory response in pregnant women with periodontitis who voluntarily attend to the Dentistry Service of the Provincial Maternity. 100 pregnant and 50 non-pregnant women who signed the consent to participate in the project (REPIS Registry 3065/16) were studied. All periodontal parameters were evaluated. From each sextant, samples were taken from the deepest pocket for microbiological identification by molecular biology. Samples of unstimulated saliva were taken to determine the concentration of IgA and IgG, Reactive Protein C (PCR), Myeloperoxidase (MPO) and Nitrite Concentration. Data were analyzed with the χ2 test, Fisher, T test as appropriate, a p <of 0.05 was considered significant. It was analyzed with Infostat 2018 / p software. T.denticola was identified as the most frequent bacteria in pregnant women in addition to P.intermedia (p=0.0177). The concentration of Ig A is higher in pregnant women compared to non-pregnant women (p=0.0204). The presence of P.gingivalis+T.denticola+ T.forsythia was significantly associated with high concentrations of IgA in pregnant women (p=0.03). A RR=7,95% CI (3.27-16.4) was calculated. While nitrite concentration and MOP activity was significantly lower in pregnant women. The data suggest that pregnant women are 7 times more likely to developed clinical insertion greater than or equal to 3mm and pocket deepest than 4mm when the P.gingivalis + T.denticola + T.forsythia triad is present. Elevated levels of IgA in saliva would indicate a positive response capacity of the host against red complex bacteria La periodontitis se asocia con la colonización en la superficie de los dientes y el surco gingival de bacterias anaeróbicas Gram negativas, formando un reservorio de microorganismos, endotoxinas y mediadores de inflamación, que a menudo entran a la circulación general y podrían producir un estado inflamatorio crónico, capaz de afectar la gestación produciendo una manifestación clínica más exacerbada. El objetivo fue evaluar la capacidad de respuesta inmune inflamatoria salival en embarazadas con periodontitis que asisten en forma voluntaria al Servicio de Odontología de la Maternidad Provincial. Se estudiaron 100 mujeres embarazadas y 50 no embarazadas que firmaron el consentimiento de participar en el proyecto (Registro REPIS 3065/16). A todas se les evaluaron los parámetros periodontales. De cada sextante se tomaron muestras del sitio más profundo para la identificación microbiológica por biología molecular. Se tomaron muestras de saliva sin estimular para determinar la concentración de IgA e IgG, Proteína C Reactiva, (PCR), Mieloperoxidasa (MPO) y Concentración de nitritos. Los datos se analizaron con la prueba de χ2, Fisher, test T según correspondió, un p< de 0,05 se consideró significativo. Se analizó con el software Infostat 2018/p. Se identificó T.denticola como la bacteria más frecuente en embarazadas además de P.intermedia (p=0.0177). La concentración de Ig A es mayor en mujeres embarazadas con respecto a las no embarazadas (p= 0,0204). La presencia de P.gingivalis+T.denticola+ T.forsythia se asoció significativamente con altas concentraciones de Ig A en embarazadas (p= 0.03). Se calculó un RR = 7 IC 95% (3.27-16.4).Mientras que la concentración de nitritos y la actividad MOP fue significativamente menor en embarazadas. Los datos sugieren que las embarazadas tienen 7 veces más posibilidades de desarrollar  pérdida de inserción NIC mayor o igual a 3mm y bolsas mayores a 4mm cuando está presente la triada P.gingivalis+T.denticola+T.forsythia. Los niveles elevados de Ig A en saliva estarían indicando una capacidad de respuesta positiva del huésped frente a las bacterias del complejo rojo Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2019-10-18 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/25831 Revista de la Facultad de Ciencias Médicas de Córdoba.; 2019: Suplemento JIC XX Revista de la Facultad de Ciencias Médicas de Córdoba; 2019: Suplemento JIC XX Revista da Faculdade de Ciências Médicas de Córdoba; 2019: Suplemento JIC XX 1853-0605 0014-6722 10.31053/1853.0605.v76.nSuplemento spa https://revistas.unc.edu.ar/index.php/med/article/view/25831/27666 Derechos de autor 2019 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0

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