Candida lipases: a review on biochemical, molecular and pathogenic aspects

In the last half century there was a significant increase in the incidence of fungal infections being likely to become a global health priority. The sophisticated degree of host-Candida interaction is the product of different virulence strategies used by the fungus to invade the tissues and the vari...

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Detalles Bibliográficos
Autores principales: Castillo, Graciela del Valle, Azcurra, Ana Isabel, Sotomayor, Claudia Elena
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2019
Materias:
lipasas
candida
terapia molecular dirigida
lipases
molecular targeted therapy
terapia de alvo molecular
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/23822
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
id I10-R327-article-23822
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institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Español
format Artículo revista
topic lipasas
candida
terapia molecular dirigida
lipases
candida
molecular targeted therapy
lipases
candida
terapia de alvo molecular
spellingShingle lipasas
candida
terapia molecular dirigida
lipases
candida
molecular targeted therapy
lipases
candida
terapia de alvo molecular
Castillo, Graciela del Valle
Azcurra, Ana Isabel
Sotomayor, Claudia Elena
Candida lipases: a review on biochemical, molecular and pathogenic aspects
topic_facet lipasas
candida
terapia molecular dirigida
lipases
candida
molecular targeted therapy
lipases
candida
terapia de alvo molecular
author Castillo, Graciela del Valle
Azcurra, Ana Isabel
Sotomayor, Claudia Elena
author_facet Castillo, Graciela del Valle
Azcurra, Ana Isabel
Sotomayor, Claudia Elena
author_sort Castillo, Graciela del Valle
title Candida lipases: a review on biochemical, molecular and pathogenic aspects
title_short Candida lipases: a review on biochemical, molecular and pathogenic aspects
title_full Candida lipases: a review on biochemical, molecular and pathogenic aspects
title_fullStr Candida lipases: a review on biochemical, molecular and pathogenic aspects
title_full_unstemmed Candida lipases: a review on biochemical, molecular and pathogenic aspects
title_sort candida lipases: a review on biochemical, molecular and pathogenic aspects
description In the last half century there was a significant increase in the incidence of fungal infections being likely to become a global health priority. The sophisticated degree of host-Candida interaction is the product of different virulence strategies used by the fungus to invade the tissues and the various defense mechanisms that it develops to control it. There is a significant amount of literature that indicates that this opportunistic commensal fungus has components that can be considered virulence factors related to the stage of the infectious process. Among the virulence factors of this fungus can be mentioned the adherence to cell surfaces, the formation of biofilms and the production of hydrolytic enzymes. The most studied hydrolases secreted by C. albicans are aspartyl proteinases, phospholipases and esterases, while lipases have been the least studied. These enzymes would have the function to facilitate active penetration into the cells, participating in the digestion and synthesis of lipid esters for their nutrition and contributing to the invasion of the tissue by hydrolyzing the lipid components of the host cell membranes. There is also bibliographic evidence that these enzymes are capable to damage cells and molecules of the immune system to avoid the antimicrobial activity.Taking into account the foregoing, this review provides an updated description of biochemical and molecular characteristics of the lipases secreted by Candida, its role as a virulence factor and its potential for the development of new antifungal drugs.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2019
url https://revistas.unc.edu.ar/index.php/med/article/view/23822
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spelling I10-R327-article-238222024-08-27T18:24:50Z Candida lipases: a review on biochemical, molecular and pathogenic aspects Lipasas de especies Candida: una revisión sobre aspectos bioquímicos, moleculares y patogénicos Lipases de Candida: uma revisão sobre aspectos bioquímicos, moleculares e patogênicos Castillo, Graciela del Valle Azcurra, Ana Isabel Sotomayor, Claudia Elena lipasas candida terapia molecular dirigida lipases candida molecular targeted therapy lipases candida terapia de alvo molecular In the last half century there was a significant increase in the incidence of fungal infections being likely to become a global health priority. The sophisticated degree of host-Candida interaction is the product of different virulence strategies used by the fungus to invade the tissues and the various defense mechanisms that it develops to control it. There is a significant amount of literature that indicates that this opportunistic commensal fungus has components that can be considered virulence factors related to the stage of the infectious process. Among the virulence factors of this fungus can be mentioned the adherence to cell surfaces, the formation of biofilms and the production of hydrolytic enzymes. The most studied hydrolases secreted by C. albicans are aspartyl proteinases, phospholipases and esterases, while lipases have been the least studied. These enzymes would have the function to facilitate active penetration into the cells, participating in the digestion and synthesis of lipid esters for their nutrition and contributing to the invasion of the tissue by hydrolyzing the lipid components of the host cell membranes. There is also bibliographic evidence that these enzymes are capable to damage cells and molecules of the immune system to avoid the antimicrobial activity.Taking into account the foregoing, this review provides an updated description of biochemical and molecular characteristics of the lipases secreted by Candida, its role as a virulence factor and its potential for the development of new antifungal drugs. En el último medio siglo se produjo un aumento significativo en la incidencia de infecciones fúngicas siendo probable que se conviertan en una prioridad de salud global. El sofisticado grado de interacción hospedador-Candida es producto de diferentes estrategias de virulencia que utiliza el hongo para invadir los tejidos y de los diversos mecanismos de defensa que este último desarrolla para controlarlo. Existe bibliografía que indica que este hongo comensal oportunista posee componentes que pueden ser considerados factores de virulencia asociados a la etapa del proceso infeccioso. Dentro de los factores de virulencia de este hongo pueden mencionarse la adherencia a las superficies celulares, la formación de biofilms y la producción de enzimas hidrolíticas. Las hidrolasas secretadas por C. albicans más estudiadas son las aspartil proteinasas, las fosfolipasas y las esterasas, mientras que las lipasas han sido las menos exploradas. Estas enzimas tendrían como función facilitar la penetración activa en las células, participar en la digestión y síntesis de ésteres de lípidos para su nutrición y contribuir a la invasión del tejido al hidrolizar los componentes lipídicos de las membranas celulares del hospedador. También hay evidencia bibliográfica que indica que estas enzimas son capaces de dañar células y moléculas del sistema inmune para evitar la actividad antimicrobiana. Teniendo en cuenta lo precedente, esta revisión, proporciona una actualizada descripción de las características bioquímicas y moleculares de las lipasas secretadas por el hongo Candida, su rol como factor de virulencia y su potencial para el desarrollo de nuevos fármacos antifúngicos. No último meio século, houve um aumento significativo na incidência de infecções fúngicas, o que provavelmente se tornará uma prioridade de saúde global. O grau de interacção sofisticado produto hospedeiro-Candida é diferentes estratégias de virulência, utilizando o fungo para invadir tecidos e diversos mecanismos de defesa para controlar este último desenvolve. Não existe literatura que indica que este fungo oportunista comensais tem componentes que podem ser considerados factores de virulência associados com a fase de infecção. Dentro dos factores de virulência do fungo podem ser mencionados aderência a superfícies de células, a formação de biofilme e de produção de enzimas hidrolíticas. Hidrolases segregadas por C. albicans mais estudados são de aspartil proteinases, fosfolipases e esterases, enquanto que as lipases têm sido menos explorado. Estas enzimas têm a função de facilitar a penetração activa em células envolvidas na digestão, e a síntese de ésteres de lípidos para a nutrição e contribuir para a invasão de tecidos por hidrólise dos componentes lipídicos das membranas das células do hospedeiro. Há também evidência na literatura de que estas enzimas são capazes de células e moléculas do sistema imunológico para evitar danificar a actividade antimicrobiana. Face ao exposto, esta avaliação, fornece uma descrição actualizada das características bioquímicas e moleculares de lipases segregadas pelo fungo Candida, o seu papel como um factor de virulência e o potencial para o desenvolvimento de novos agentes antifúngicos. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2019-06-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html image/tiff image/tiff image/tiff application/vnd.openxmlformats-officedocument.spreadsheetml.sheet application/vnd.openxmlformats-officedocument.wordprocessingml.document https://revistas.unc.edu.ar/index.php/med/article/view/23822 10.31053/1853.0605.v76.n2.23822 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 76 No. 2 (2019); 107-112 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 76 Núm. 2 (2019); 107-112 Revista da Faculdade de Ciências Médicas de Córdoba; v. 76 n. 2 (2019); 107-112 1853-0605 0014-6722 10.31053/1853.0605.v76.n2 spa https://revistas.unc.edu.ar/index.php/med/article/view/23822/23481 https://revistas.unc.edu.ar/index.php/med/article/view/23822/23673 https://revistas.unc.edu.ar/index.php/med/article/view/23822/27285 https://revistas.unc.edu.ar/index.php/med/article/view/23822/27286 https://revistas.unc.edu.ar/index.php/med/article/view/23822/27287 https://revistas.unc.edu.ar/index.php/med/article/view/23822/27288 https://revistas.unc.edu.ar/index.php/med/article/view/23822/27289 Derechos de autor 2019 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0

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