Relationship between rhinitis severity and lung function in children and adolescents without asthma

Background: The link between upper and lower airways is recognized clinically as a “unique airway”. Subclinical spirometric abnormalities have been observed in patients with rhinitis without asthma, which could be proportional to rhinitis severity. Objectives: To investigate possible subclinical alt...

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Autores principales: Saranz, Ricardo José, Agresta, María Fernanda, Lozano, Natalia Andrea, Alegre, Graciela, Sasia, Laura Verónica, Ianiero, Luciano, Berardi, Yanina Viviana, Lozano, Alejandro
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2019
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Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/23761
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institution Universidad Nacional de Córdoba
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container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Español
format Artículo revista
topic rhinitis
classification
spirometry
rinitis
clasificación
espirometría
rinite
classificação
espirometria
spellingShingle rhinitis
classification
spirometry
rinitis
clasificación
espirometría
rinite
classificação
espirometria
Saranz, Ricardo José
Agresta, María Fernanda
Lozano, Natalia Andrea
Alegre, Graciela
Sasia, Laura Verónica
Ianiero, Luciano
Berardi, Yanina Viviana
Lozano, Alejandro
Relationship between rhinitis severity and lung function in children and adolescents without asthma
topic_facet rhinitis
classification
spirometry
rinitis
clasificación
espirometría
rinite
classificação
espirometria
author Saranz, Ricardo José
Agresta, María Fernanda
Lozano, Natalia Andrea
Alegre, Graciela
Sasia, Laura Verónica
Ianiero, Luciano
Berardi, Yanina Viviana
Lozano, Alejandro
author_facet Saranz, Ricardo José
Agresta, María Fernanda
Lozano, Natalia Andrea
Alegre, Graciela
Sasia, Laura Verónica
Ianiero, Luciano
Berardi, Yanina Viviana
Lozano, Alejandro
author_sort Saranz, Ricardo José
title Relationship between rhinitis severity and lung function in children and adolescents without asthma
title_short Relationship between rhinitis severity and lung function in children and adolescents without asthma
title_full Relationship between rhinitis severity and lung function in children and adolescents without asthma
title_fullStr Relationship between rhinitis severity and lung function in children and adolescents without asthma
title_full_unstemmed Relationship between rhinitis severity and lung function in children and adolescents without asthma
title_sort relationship between rhinitis severity and lung function in children and adolescents without asthma
description Background: The link between upper and lower airways is recognized clinically as a “unique airway”. Subclinical spirometric abnormalities have been observed in patients with rhinitis without asthma, which could be proportional to rhinitis severity. Objectives: To investigate possible subclinical alterations in lung function and bronchodilator reversibility in children and adolescents with allergic (AR) and non-allergic rhinitis (NAR) without asthma, according to the clinical grade of rhinitis classified by ARIA (Allergic Rhinitis and Its Impact on Asthma). Methods: In a cross-sectional analytical study, we included patients aged 5 to 18 years with symptoms of AR and NAR without asthma. Spirometry was performed by flow-volume curve and we analyzed the abnormalities in respiratory function and bronchodilator response in relation to clinical grade of rhinitis by ARIA using an adjusted logistic model. Results: We studied 193 patients; 42 (21.7%) had some spirometric abnormalities.  Patients with moderate-severe persistent rhinitis had greater impairment of lung function compared to the other grades of rhinitis (p=0.009). This defect was associated with both frequency (p=0.03) and severity of rhinitis (p=0.04) but not with atopic status (p=0.28). A positive bronchodilator response was more frequent in grades moderate-severe of rhinitis than in mild forms (p=0.04). Conclusion: Abnormalities of lung function was more prevalent in moderate-severe persistent rhinitis and was associated with the frequency and severity of rhinitis but not to atopic status.  The bronchodilator reversibility was observed in patients with intermittent and persistent moderate-severe rhinitis.  
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2019
url https://revistas.unc.edu.ar/index.php/med/article/view/23761
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spelling I10-R327-article-237612024-08-27T18:24:46Z Relationship between rhinitis severity and lung function in children and adolescents without asthma Relación entre grado clínico de rinitis y función pulmonar en niños y adolescentes sin asma Relação entre grau clínico de rinite e função pulmonar em crianças e adolescentes em asma Saranz, Ricardo José Agresta, María Fernanda Lozano, Natalia Andrea Alegre, Graciela Sasia, Laura Verónica Ianiero, Luciano Berardi, Yanina Viviana Lozano, Alejandro rhinitis classification spirometry rinitis clasificación espirometría rinite classificação espirometria Background: The link between upper and lower airways is recognized clinically as a “unique airway”. Subclinical spirometric abnormalities have been observed in patients with rhinitis without asthma, which could be proportional to rhinitis severity. Objectives: To investigate possible subclinical alterations in lung function and bronchodilator reversibility in children and adolescents with allergic (AR) and non-allergic rhinitis (NAR) without asthma, according to the clinical grade of rhinitis classified by ARIA (Allergic Rhinitis and Its Impact on Asthma). Methods: In a cross-sectional analytical study, we included patients aged 5 to 18 years with symptoms of AR and NAR without asthma. Spirometry was performed by flow-volume curve and we analyzed the abnormalities in respiratory function and bronchodilator response in relation to clinical grade of rhinitis by ARIA using an adjusted logistic model. Results: We studied 193 patients; 42 (21.7%) had some spirometric abnormalities.  Patients with moderate-severe persistent rhinitis had greater impairment of lung function compared to the other grades of rhinitis (p=0.009). This defect was associated with both frequency (p=0.03) and severity of rhinitis (p=0.04) but not with atopic status (p=0.28). A positive bronchodilator response was more frequent in grades moderate-severe of rhinitis than in mild forms (p=0.04). Conclusion: Abnormalities of lung function was more prevalent in moderate-severe persistent rhinitis and was associated with the frequency and severity of rhinitis but not to atopic status.  The bronchodilator reversibility was observed in patients with intermittent and persistent moderate-severe rhinitis.   Introducción: Las vías aéreas superior e inferior se comportan como una unidad. Se han observado alteraciones espirométricas subclínicas en pacientes con rinitis, sin asma, que podrían ser proporcionales a la magnitud de la rinitis. Objetivos: Investigar las posibles alteraciones de la función pulmonar y reversibilidad al broncodilatador en niños y adolescentes con rinitis alérgica (RA) y no alérgica (RNA), sin asma, según el grado clínico de rinitis establecido por ARIA (Rinitis Alérgica y su Impacto en Asma). Población y métodos: Estudio transversal analítico. Se incluyeron pacientes entre 5 y 18 años con RA y RNA, sin asma. Se analizó la existencia de anormalidades en la función pulmonar (curva flujo-volumen) y la respuesta broncodilatadora en relación al grado clínico de rinitis por ARIA ajustando un modelo logístico. Resultados: Se estudiaron 193 pacientes; 42 (21,7%) tuvieron al menos un parámetro espirométrico alterado. Los pacientes con rinitis persistente moderada-grave presentaron mayor afectación de la función pulmonar respecto a otros grados de rinitis (p=0,009). El defecto se asoció a la frecuencia (p=0,03) y a la gravedad de la rinitis (p=0,04) pero no con la atopia (p=0,28). La respuesta broncodilatadora positiva fue más frecuente en los grados de rinitis moderada-grave que en los leves (p=0,04). Conclusiones: La alteración de la función pulmonar fue más prevalente en la rinitis persistente moderada-grave y se asoció a la frecuencia y la gravedad de la rinitis pero fue independiente de la condición de atopia. La reversibilidad al broncodilatador se observó en pacientes con rinitis intermitente y persistente moderada-grave. Introdução: As vias aéreas superiores e inferiores se comportam como uma unidade. Foram observadas alterações espirométricas subclínicas em pacientes com rinite, sem asma , que pode ser proporcional à magnitude da rinite. Objetivos: Investigar as possíveis alterações na função pulmonar e reversibilidade ao broncodilatador em crianças e adolescentes com rinite alérgica (AR) e não alérgica (RNA), sem asma , de acordó com o grau clínico de rinite estabelecido pela ARIA (Rinite Alérgica e seu Impacto sobre Asma). População e métodos: Estudo analítico de corte transversal, que incluiu pacientes entre 5 e 18 anos com AR e RNA, sem asma. Analisou-se a existência de anormalidades na função pulmonar (curva de fluxo-volume) e a resposta broncodilatadora em relação ao grau clínico de rinite pela ARIA ajustando um modelo logístico. Resultados: 193 pacientes foram estudados; 42 (21,7%) apresentavam pelo menos um parâmetro espirométrico alterado. Os pacientes com rinite persistente moderada-grave apresentaram maior comprometimento da função pulmonar em relação aos outros graus de rinite (p=0,009). O defeito foi relacionado com a frequência (p=0,03) e a gravidade da rinite (p= 0,04), mas não com atopia (p=0,28). A resposta positiva ao broncodilatador foi mais frequente nos graus de rinite moderada-grave do que nos leves (p = 0,04). Conclusões: A alteração na função pulmonar foi mais prevalente em rinite persistente moderada a grave e foi associado com a frequência e a gravidade da rinite, mas foi independente da condição de atopia. A reversibilidade ao broncodilatador foi observada em pacientes com rinite moderada a grave intermitente e persistente. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2019-08-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html https://revistas.unc.edu.ar/index.php/med/article/view/23761 10.31053/1853.0605.v76.n3.23761 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 76 No. 3 (2019); 164-169 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 76 Núm. 3 (2019); 164-169 Revista da Faculdade de Ciências Médicas de Córdoba; v. 76 n. 3 (2019); 164-169 1853-0605 0014-6722 10.31053/1853.0605.v76.n3 spa https://revistas.unc.edu.ar/index.php/med/article/view/23761/24538 https://revistas.unc.edu.ar/index.php/med/article/view/23761/24557 Derechos de autor 2019 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0