Characterization of the HIV-1 subtypes present in Cordoba (Argentina) from nearly the beginning of the infection, using the POL and ENV genes

Objective: In the present study we characterize, using a retrospective approach, the HIV-1 infection in Córdoba, Argentina, by determining the viral subtypes circulating in the period 1986-2001. Methods: The pol and env genes were analyzed using two different approaches: 1) comparing the sequences f...

Descripción completa

Detalles Bibliográficos
Autores principales: Gonzalez Ittig, Raul Enrique, Lucca, María A., Caeiro, Luciana, Modesti, Nidia M.
Formato: Artículo revista
Lenguaje:Inglés
Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2017
Materias:
HIV-1 infection
Córdoba
Argentina
HIV-1 subtypes
phylogenetic analyses
inter subtype recombinant strains
infección de VIH-1
subtipos de VIH-1
análisis filogenéticos
cepas recombinantes inter-subtipo
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/15282
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
id I10-R327-article-15282
record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Inglés
Español
format Artículo revista
topic HIV-1 infection
Córdoba
Argentina
HIV-1 subtypes
phylogenetic analyses
inter subtype recombinant strains
infección de VIH-1
Córdoba
Argentina
subtipos de VIH-1
análisis filogenéticos
cepas recombinantes inter-subtipo
spellingShingle HIV-1 infection
Córdoba
Argentina
HIV-1 subtypes
phylogenetic analyses
inter subtype recombinant strains
infección de VIH-1
Córdoba
Argentina
subtipos de VIH-1
análisis filogenéticos
cepas recombinantes inter-subtipo
Gonzalez Ittig, Raul Enrique
Lucca, María A.
Caeiro, Luciana
Modesti, Nidia M.
Characterization of the HIV-1 subtypes present in Cordoba (Argentina) from nearly the beginning of the infection, using the POL and ENV genes
topic_facet HIV-1 infection
Córdoba
Argentina
HIV-1 subtypes
phylogenetic analyses
inter subtype recombinant strains
infección de VIH-1
Córdoba
Argentina
subtipos de VIH-1
análisis filogenéticos
cepas recombinantes inter-subtipo
author Gonzalez Ittig, Raul Enrique
Lucca, María A.
Caeiro, Luciana
Modesti, Nidia M.
author_facet Gonzalez Ittig, Raul Enrique
Lucca, María A.
Caeiro, Luciana
Modesti, Nidia M.
author_sort Gonzalez Ittig, Raul Enrique
title Characterization of the HIV-1 subtypes present in Cordoba (Argentina) from nearly the beginning of the infection, using the POL and ENV genes
title_short Characterization of the HIV-1 subtypes present in Cordoba (Argentina) from nearly the beginning of the infection, using the POL and ENV genes
title_full Characterization of the HIV-1 subtypes present in Cordoba (Argentina) from nearly the beginning of the infection, using the POL and ENV genes
title_fullStr Characterization of the HIV-1 subtypes present in Cordoba (Argentina) from nearly the beginning of the infection, using the POL and ENV genes
title_full_unstemmed Characterization of the HIV-1 subtypes present in Cordoba (Argentina) from nearly the beginning of the infection, using the POL and ENV genes
title_sort characterization of the hiv-1 subtypes present in cordoba (argentina) from nearly the beginning of the infection, using the pol and env genes
description Objective: In the present study we characterize, using a retrospective approach, the HIV-1 infection in Córdoba, Argentina, by determining the viral subtypes circulating in the period 1986-2001. Methods: The pol and env genes were analyzed using two different approaches: 1) comparing the sequences from Córdoba with those of pure subtypes and circulating recombinant forms of the HIV-1 M group; 2) subdividing the sequences into pure-subtype data sets (avoiding the effects of recombination) to determine if the subtypes from Córdoba have a single or multiple geographic origins. Results: The first approach revealed that eighteen strains were subtype B, seven B/F1, one C and one F1. Only two of the B/F1 corresponded to the CRF12_B/F1, previously described for Argentina; the remaining B/F1 sequences could be considered different forms of URF_B/F1. The Phylogenetic results of the second approach suggest that in Córdoba subtype B would have multiple geographic origins, while subtypes F1 and C would have been introduced directly from Brazil or indirectly from Buenos Aires. Conclusions: The great subtype variability indicates that the HIV-1 infection in Córdoba was complex since its very beginning. Our results also reveal the close contact of people of this city, through tourism and commercial activities, with those from Buenos Aires and Brazil.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2017
url https://revistas.unc.edu.ar/index.php/med/article/view/15282
work_keys_str_mv AT gonzalezittigraulenrique characterizationofthehiv1subtypespresentincordobaargentinafromnearlythebeginningoftheinfectionusingthepolandenvgenes
AT luccamariaa characterizationofthehiv1subtypespresentincordobaargentinafromnearlythebeginningoftheinfectionusingthepolandenvgenes
AT caeiroluciana characterizationofthehiv1subtypespresentincordobaargentinafromnearlythebeginningoftheinfectionusingthepolandenvgenes
AT modestinidiam characterizationofthehiv1subtypespresentincordobaargentinafromnearlythebeginningoftheinfectionusingthepolandenvgenes
AT gonzalezittigraulenrique caracterizaciondelossubtiposdevih1presentesencordobaargentinadesdecasieliniciodelainfeccionutilizandolosgenespolyenv
AT luccamariaa caracterizaciondelossubtiposdevih1presentesencordobaargentinadesdecasieliniciodelainfeccionutilizandolosgenespolyenv
AT caeiroluciana caracterizaciondelossubtiposdevih1presentesencordobaargentinadesdecasieliniciodelainfeccionutilizandolosgenespolyenv
AT modestinidiam caracterizaciondelossubtiposdevih1presentesencordobaargentinadesdecasieliniciodelainfeccionutilizandolosgenespolyenv
first_indexed 2024-09-03T20:58:22Z
last_indexed 2024-09-03T20:58:22Z
_version_ 1809209992398503936
spelling I10-R327-article-152822024-08-27T18:20:19Z Characterization of the HIV-1 subtypes present in Cordoba (Argentina) from nearly the beginning of the infection, using the POL and ENV genes Caracterización de los subtipos de VIH-1 presentes en Córdoba (Argentina) desde casi el inicio de la infección, utilizando los genes POL y ENV Gonzalez Ittig, Raul Enrique Lucca, María A. Caeiro, Luciana Modesti, Nidia M. HIV-1 infection Córdoba Argentina HIV-1 subtypes phylogenetic analyses inter subtype recombinant strains infección de VIH-1 Córdoba Argentina subtipos de VIH-1 análisis filogenéticos cepas recombinantes inter-subtipo Objective: In the present study we characterize, using a retrospective approach, the HIV-1 infection in Córdoba, Argentina, by determining the viral subtypes circulating in the period 1986-2001. Methods: The pol and env genes were analyzed using two different approaches: 1) comparing the sequences from Córdoba with those of pure subtypes and circulating recombinant forms of the HIV-1 M group; 2) subdividing the sequences into pure-subtype data sets (avoiding the effects of recombination) to determine if the subtypes from Córdoba have a single or multiple geographic origins. Results: The first approach revealed that eighteen strains were subtype B, seven B/F1, one C and one F1. Only two of the B/F1 corresponded to the CRF12_B/F1, previously described for Argentina; the remaining B/F1 sequences could be considered different forms of URF_B/F1. The Phylogenetic results of the second approach suggest that in Córdoba subtype B would have multiple geographic origins, while subtypes F1 and C would have been introduced directly from Brazil or indirectly from Buenos Aires. Conclusions: The great subtype variability indicates that the HIV-1 infection in Córdoba was complex since its very beginning. Our results also reveal the close contact of people of this city, through tourism and commercial activities, with those from Buenos Aires and Brazil. Objetivo: En el presente estudio, utilizando un enfoque retrospectivo, caracterizamos la infección de VIH-1 en Córdoba (Argentina) a través de la determinación de los subtipos virales circulantes en el período 1986-2001. Métodos: Se analizaron los genes pol y env utilizando dos enfoques diferentes: 1) comparando las secuencias de Córdoba con aquellas de subtipos puros y formas recombinantes circulantes del grupo M del VIH-1; 2) subdividiendo las secuencias en matrices de subtipos puros (evitando los efectos de la recombinación) a fin de determinar si los subtipos de Córdoba tienen uno o varios orígenes geográficos. Resultados: El primer enfoque reveló que dieciocho cepas correspondían al subtipo B, siete a B/F1, una a C y una a F1. Solo dos de los B/F1 correspondían a la forma CRF12_B/F1, previamente descripta para Argentina; las secuencias B/F1 restantes serían diferentes formas de URF_B/F1. Los análisis filogenéticos del segundo enfoque sugieren que el subtipo B de Córdoba tendría múltiples orígenes geográficos, mientras que los subtipos F1 y C habrían sido introducidos directamente desde Brasil o indirectamente desde Buenos Aires. Conclusiones: La gran variabilidad de subtipos indica que la infección de VIH-1 en Córdoba fue compleja desde sus inicios. Nuestros resultados también revelan el estrecho contacto entre la gente de esta ciudad, a través del turismo y actividades comerciales, con las de Buenos Aires y Brasil. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2017-09-08 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf application/vnd.openxmlformats-officedocument.wordprocessingml.document image/jpeg image/jpeg image/jpeg image/jpeg image/jpeg https://revistas.unc.edu.ar/index.php/med/article/view/15282 10.31053/1853.0605.v74.n3.15282 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 74 No. 3 (2017); 219-230 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 74 Núm. 3 (2017); 219-230 Revista da Faculdade de Ciências Médicas de Córdoba; v. 74 n. 3 (2017); 219-230 1853-0605 0014-6722 10.31053/1853.0605.v74.n3 eng spa https://revistas.unc.edu.ar/index.php/med/article/view/15282/19248 https://revistas.unc.edu.ar/index.php/med/article/view/15282/26174 https://revistas.unc.edu.ar/index.php/med/article/view/15282/26175 https://revistas.unc.edu.ar/index.php/med/article/view/15282/26176 https://revistas.unc.edu.ar/index.php/med/article/view/15282/26177 https://revistas.unc.edu.ar/index.php/med/article/view/15282/26178 https://revistas.unc.edu.ar/index.php/med/article/view/15282/26179 Derechos de autor 2017 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0

Ejemplares similares