A tale of agriculturalists and hunter-gatherers: Exploring the thrifty genotype hypothesis in native South Americans

Objectives: To determine genetic differences between agriculturalist and hunter-gatherer southern Native American populations for selected metabolism-related markers and to test whether Neel's thrifty genotype hypothesis (TGH) could explain the genetic patterns observed in these populations. Ma...

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Detalles Bibliográficos
Autores principales: Reales, Guillermo, Rovaris, Diego L., Jacovas, Vanessa C., Hünemeier, Tábita, Sandoval, José R., Salazar Granara, Alcibiades, Demarchi, Dario, Tarazona Santos, Eduardo, Felkl, Aline B., Serafini, Michele A., Salzano, Francisco M., Bisso Machado, Rafael, Comas, David, Paixão Côrtes, Vanessa R., Bortolini, Maria Catira
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: Wiley-liss, Div John Wiley & Sons Inc 2017
Materias:
ADAPTATION
APOE
MODE OF SUBSISTENCE
PLEIOTROPY
Otras Ciencias Biológicas
Ciencias Biológicas
CIENCIAS NATURALES Y EXACTAS
Genética y Herencia
Acceso en línea:http://hdl.handle.net/11336/63293
http://suquia.ffyh.unc.edu.ar/handle/11336/63293
Aporte de:
Suquía - Instituto de Antropología de Córdoba (IDACOR, CONICET y UNC) de Universidad Nacional de Córdoba
id I10-R181-11336-63293
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-181
collection Suquía - Instituto de Antropología de Córdoba (IDACOR, CONICET y UNC)
language Inglés
topic ADAPTATION
APOE
MODE OF SUBSISTENCE
PLEIOTROPY
Otras Ciencias Biológicas
Ciencias Biológicas
CIENCIAS NATURALES Y EXACTAS
Genética y Herencia
Ciencias Biológicas
CIENCIAS NATURALES Y EXACTAS
spellingShingle ADAPTATION
APOE
MODE OF SUBSISTENCE
PLEIOTROPY
Otras Ciencias Biológicas
Ciencias Biológicas
CIENCIAS NATURALES Y EXACTAS
Genética y Herencia
Ciencias Biológicas
CIENCIAS NATURALES Y EXACTAS
Reales, Guillermo
Rovaris, Diego L.
Jacovas, Vanessa C.
Hünemeier, Tábita
Sandoval, José R.
Salazar Granara, Alcibiades
Demarchi, Dario
Tarazona Santos, Eduardo
Felkl, Aline B.
Serafini, Michele A.
Salzano, Francisco M.
Bisso Machado, Rafael
Comas, David
Paixão Côrtes, Vanessa R.
Bortolini, Maria Catira
A tale of agriculturalists and hunter-gatherers: Exploring the thrifty genotype hypothesis in native South Americans
topic_facet ADAPTATION
APOE
MODE OF SUBSISTENCE
PLEIOTROPY
Otras Ciencias Biológicas
Ciencias Biológicas
CIENCIAS NATURALES Y EXACTAS
Genética y Herencia
Ciencias Biológicas
CIENCIAS NATURALES Y EXACTAS
description Objectives: To determine genetic differences between agriculturalist and hunter-gatherer southern Native American populations for selected metabolism-related markers and to test whether Neel's thrifty genotype hypothesis (TGH) could explain the genetic patterns observed in these populations. Materials and Methods: 375 Native South American individuals from 17 populations were genotyped using six markers (APOE rs429358 and rs7412; APOA2 rs5082; CD36 rs3211883; TCF7L2 rs11196205; and IGF2BP2 rs11705701). Additionally, APOE genotypes from 39 individuals were obtained from the literature. AMOVA, main effects, and gene-gene interaction tests were performed. Results: We observed differences in allele distribution patterns between agriculturalists and hunter-gatherers for some markers. For instance, between-groups component of genetic variance (FCT) for APOE rs429358 showed strong differences in allelic distributions between hunter-gatherers and agriculturalists (p = 0.00196). Gene-gene interaction analysis indicated that the APOE E4/CD36 TT and APOE E4/IGF2BP2 A carrier combinations occur at a higher frequency in hunter-gatherers, but this combination is not replicated in archaic (Neanderthal and Denisovan) and ancient (Anzick, Saqqaq, Ust-Ishim, Mal'ta) hunter-gatherer individuals. Discussion: A complex scenario explains the observed frequencies of the tested markers in hunter-gatherers. Different factors, such as pleotropic alleles, rainforest selective pressures, and population dynamics, may be collectively shaping the observed genetic patterns. We conclude that although TGH seems a plausible hypothesis to explain part of the data, other factors may be important in our tested populations.
format Artículo
Artículo
publishedVersion
author Reales, Guillermo
Rovaris, Diego L.
Jacovas, Vanessa C.
Hünemeier, Tábita
Sandoval, José R.
Salazar Granara, Alcibiades
Demarchi, Dario
Tarazona Santos, Eduardo
Felkl, Aline B.
Serafini, Michele A.
Salzano, Francisco M.
Bisso Machado, Rafael
Comas, David
Paixão Côrtes, Vanessa R.
Bortolini, Maria Catira
author_facet Reales, Guillermo
Rovaris, Diego L.
Jacovas, Vanessa C.
Hünemeier, Tábita
Sandoval, José R.
Salazar Granara, Alcibiades
Demarchi, Dario
Tarazona Santos, Eduardo
Felkl, Aline B.
Serafini, Michele A.
Salzano, Francisco M.
Bisso Machado, Rafael
Comas, David
Paixão Côrtes, Vanessa R.
Bortolini, Maria Catira
author_sort Reales, Guillermo
title A tale of agriculturalists and hunter-gatherers: Exploring the thrifty genotype hypothesis in native South Americans
title_short A tale of agriculturalists and hunter-gatherers: Exploring the thrifty genotype hypothesis in native South Americans
title_full A tale of agriculturalists and hunter-gatherers: Exploring the thrifty genotype hypothesis in native South Americans
title_fullStr A tale of agriculturalists and hunter-gatherers: Exploring the thrifty genotype hypothesis in native South Americans
title_full_unstemmed A tale of agriculturalists and hunter-gatherers: Exploring the thrifty genotype hypothesis in native South Americans
title_sort tale of agriculturalists and hunter-gatherers: exploring the thrifty genotype hypothesis in native south americans
publisher Wiley-liss, Div John Wiley & Sons Inc
publishDate 2017
url http://hdl.handle.net/11336/63293
http://suquia.ffyh.unc.edu.ar/handle/11336/63293
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