Generation and characterization of novel magnetic field-responsive biomaterials.
We report the preparation of novel magnetic field-responsive tissue substitutes based on biocompatible multi-domain magnetic particles dispersed in a fibrin–agarose biopolymer scaffold. We characterized our biomaterials with several experimental techniques. First we analyzed their microstructure and...
| Autores principales: | , , , , , , |
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| Formato: | article |
| Lenguaje: | Inglés |
| Publicado: |
PloS One.
2017
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/11086/4931 |
| Aporte de: |
| id |
I10-R14111086-4931 |
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| record_format |
dspace |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-141 |
| collection |
Repositorio Digital Universitario (UNC) |
| language |
Inglés |
| topic |
Biocompatible materials Family characteristics Characterization |
| spellingShingle |
Biocompatible materials Family characteristics Characterization López López, M.T. Scionti, G. Oliveira, A.C. G. Durán, J.D. Campos, A. Alaminos, M. Rodríguez, I.A. Generation and characterization of novel magnetic field-responsive biomaterials. |
| topic_facet |
Biocompatible materials Family characteristics Characterization |
| description |
We report the preparation of novel magnetic field-responsive tissue substitutes based on biocompatible multi-domain magnetic particles dispersed in a fibrin–agarose biopolymer scaffold. We characterized our biomaterials with several experimental techniques. First we analyzed their microstructure and found that it was strongly affected by the presence of magnetic particles, especially when a magnetic field was applied at the start of polymer gelation. In these samples we observed parallel stripes consisting of closely packed fibers, separated by more isotropic net-like spaces. We then studied the viability of oral mucosa
fibroblasts in the magnetic scaffolds and found no significant differences compared to positive control samples. Finally, we analyzed the magnetic and mechanical properties of the tissue substitutes. Differences in microstructural patterns of the tissue substitutes correlated with their macroscopic mechanical properties. We also found that the mechanical properties of our magnetic tissue substitutes could be reversibly tuned by noncontact magnetic forces.This unique advantage with respect to other biomaterials could be used to match the mechanical properties of the tissue substitutes to those of potential target tissues in tissue engineering applications. |
| format |
article |
| author |
López López, M.T. Scionti, G. Oliveira, A.C. G. Durán, J.D. Campos, A. Alaminos, M. Rodríguez, I.A. |
| author_facet |
López López, M.T. Scionti, G. Oliveira, A.C. G. Durán, J.D. Campos, A. Alaminos, M. Rodríguez, I.A. |
| author_sort |
López López, M.T. |
| title |
Generation and characterization of novel magnetic field-responsive biomaterials. |
| title_short |
Generation and characterization of novel magnetic field-responsive biomaterials. |
| title_full |
Generation and characterization of novel magnetic field-responsive biomaterials. |
| title_fullStr |
Generation and characterization of novel magnetic field-responsive biomaterials. |
| title_full_unstemmed |
Generation and characterization of novel magnetic field-responsive biomaterials. |
| title_sort |
generation and characterization of novel magnetic field-responsive biomaterials. |
| publisher |
PloS One. |
| publishDate |
2017 |
| url |
http://hdl.handle.net/11086/4931 |
| work_keys_str_mv |
AT lopezlopezmt generationandcharacterizationofnovelmagneticfieldresponsivebiomaterials AT sciontig generationandcharacterizationofnovelmagneticfieldresponsivebiomaterials AT oliveiraac generationandcharacterizationofnovelmagneticfieldresponsivebiomaterials AT gduranjd generationandcharacterizationofnovelmagneticfieldresponsivebiomaterials AT camposa generationandcharacterizationofnovelmagneticfieldresponsivebiomaterials AT alaminosm generationandcharacterizationofnovelmagneticfieldresponsivebiomaterials AT rodriguezia generationandcharacterizationofnovelmagneticfieldresponsivebiomaterials |
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Repositorios |
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