Human Papillomavirus, Chlamydia trachomatis and Herpes Simplex Virus

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Introduction: Some sexually transmitted infections (STIs) are possible risk factors for oral cancer although their role as etiological agents of head and neck cancer is controversial and should be further studied. Among STI that can infect the oral mucosa stand out Human Papillomavirus (HPV), Herpes...

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Autores principales: Mosmann, Jessica Paola, Talavera, Angel Daniel, Criscuolo, María Inés, Venezuela, Raul Fernando, Kiguen, Ana Ximena, Ferreyra de Prato, Ruth, López de Blanc, Silvia, Ré, Viviana Elisabeth, Cuffini, Cecilia Gabriela
Formato: conferenceObject
Lenguaje:Inglés
Publicado: 2022
Materias:
Sexually transmitted diseases
Enfermedades de transmisión sexual
Cavidad bucal
Oral cavity
Virus del papiloma humano VPH
Alphapapillomavirus
Acceso en línea:http://hdl.handle.net/11086/24665
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R14111086-24665
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Sexually transmitted diseases
Enfermedades de transmisión sexual
Cavidad bucal
Oral cavity
Virus del papiloma humano VPH
Alphapapillomavirus
spellingShingle Sexually transmitted diseases
Enfermedades de transmisión sexual
Cavidad bucal
Oral cavity
Virus del papiloma humano VPH
Alphapapillomavirus
Mosmann, Jessica Paola
Talavera, Angel Daniel
Criscuolo, María Inés
Venezuela, Raul Fernando
Kiguen, Ana Ximena
Ferreyra de Prato, Ruth
López de Blanc, Silvia
Ré, Viviana Elisabeth
Cuffini, Cecilia Gabriela
Human Papillomavirus, Chlamydia trachomatis and Herpes Simplex Virus
topic_facet Sexually transmitted diseases
Enfermedades de transmisión sexual
Cavidad bucal
Oral cavity
Virus del papiloma humano VPH
Alphapapillomavirus
description Introduction: Some sexually transmitted infections (STIs) are possible risk factors for oral cancer although their role as etiological agents of head and neck cancer is controversial and should be further studied. Among STI that can infect the oral mucosa stand out Human Papillomavirus (HPV), Herpes Simplex Virus (HSV) and Chlamydia trachomatis (C. trachomatis), an obligate intracellular bacterium that causes inflammation and dysplasia in the cervix. Objectives: To evaluate the presence of HPV, C. trachomatis and HSV in benign, potentially malignant and cancerous oral cavity lesions, in Córdoba, Argentina. Methods: We studied oral cytobrush of lesion from 318 patients (149 men and 169 female). Samples consisted of 137 benign lesions (BL), 96 potentially malignant lesions (PML) and 85 oral squamous cell carcinomas (OSCC). These were analyzed by Polymerase Chain Reaction method and Restriction Fragment Length Polymorphism (RFLP) was used to detect HPV genotype. Results: The prevalence of HPV was 34% (n=109). The HPV detection rate was increasing as the severity of the lesion increased (28% BL, 35% PML and 42% OSCC). The most frequent HPV genotypes were 6 and 16. There was no statistical significance between HPV, lesions, genotypes and gender. However, greater detection of high-risk HPV could be observed in OSCC and low risk HPV in BL. The prevalence of C. trachomatis was 16% (n=54) and HSV was 3% (n=10). We detected 4% (n=13) co infections HPV- C. trachomatis, mostly in BL and 0.3% (n=1) co infection HPV-HSV in BL too. Conclusions. Due the association of HPV and cervical cancer and morphological similarity of genital and oropharyngeal epithelia, these preliminary results allow us to infer that the evolution of the oral lesions could be influenced not only by the conventional risk factors, also the HPV genotype detected. These results show the importance of detecting these pathogens as well as HPV genotype in all kind of oral lesions. Such data are important to improve our knowledge of the epidemiology of oral HPV and co-infections. Indeed, C. trachomatis infection can alter the normal structure of epithelial cell junctions, increasing susceptibility to HPV or HSV infection, both in genital and oral mucosa.
format conferenceObject
author Mosmann, Jessica Paola
Talavera, Angel Daniel
Criscuolo, María Inés
Venezuela, Raul Fernando
Kiguen, Ana Ximena
Ferreyra de Prato, Ruth
López de Blanc, Silvia
Ré, Viviana Elisabeth
Cuffini, Cecilia Gabriela
author_facet Mosmann, Jessica Paola
Talavera, Angel Daniel
Criscuolo, María Inés
Venezuela, Raul Fernando
Kiguen, Ana Ximena
Ferreyra de Prato, Ruth
López de Blanc, Silvia
Ré, Viviana Elisabeth
Cuffini, Cecilia Gabriela
author_sort Mosmann, Jessica Paola
title Human Papillomavirus, Chlamydia trachomatis and Herpes Simplex Virus
title_short Human Papillomavirus, Chlamydia trachomatis and Herpes Simplex Virus
title_full Human Papillomavirus, Chlamydia trachomatis and Herpes Simplex Virus
title_fullStr Human Papillomavirus, Chlamydia trachomatis and Herpes Simplex Virus
title_full_unstemmed Human Papillomavirus, Chlamydia trachomatis and Herpes Simplex Virus
title_sort human papillomavirus, chlamydia trachomatis and herpes simplex virus
publishDate 2022
url http://hdl.handle.net/11086/24665
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