Effects of ω-3 PUFA-enriched diet on growth parameters in a syngenic murine model of breast adenocarcinoma: a possible role for estrogen receptor alpha
Background: Breast cancer (BC) is the most common tumour among women and 75% of BC are estrogen receptor (ER)dependent. In particular, ERα promotes tumour growth, while ERβ has an anti-proliferative effect [1]. Epidemiological data have linked ω-3 polyunsaturated fatty acid (PUFA) consumption to...
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Lenguaje: | Inglés |
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2022
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Acceso en línea: | http://hdl.handle.net/11086/22318 |
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I10-R14111086-22318 |
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institution |
Universidad Nacional de Córdoba |
institution_str |
I-10 |
repository_str |
R-141 |
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Repositorio Digital Universitario (UNC) |
language |
Inglés |
topic |
Syngenic Breast adenocarcinoma Receptor alpha |
spellingShingle |
Syngenic Breast adenocarcinoma Receptor alpha Vara Messler, Marianela Pasqualini, María Eugenia Comba, Andrea Toniolo, Alicia Trenti, Annalisa Quiroga, Patricia Valentich, Mirta Ana Bolego, Chiara Effects of ω-3 PUFA-enriched diet on growth parameters in a syngenic murine model of breast adenocarcinoma: a possible role for estrogen receptor alpha |
topic_facet |
Syngenic Breast adenocarcinoma Receptor alpha |
description |
Background: Breast cancer (BC) is the most common tumour among women and 75% of BC are estrogen receptor
(ER)dependent. In particular, ERα promotes tumour growth, while ERβ has an anti-proliferative effect [1].
Epidemiological data have linked ω-3 polyunsaturated fatty acid (PUFA) consumption to lower incidence of BC and
several experimental studies showed the anti-proliferative effects of ω-3 fish oil in different tumour models [2,3]. Chia
seed oil is rich in α-linolenic acid (ALA 18:3 ω-3), while corn oil is rich in linoleic acid (LA 18:2 ω-6), precursors of
eicosapentaenoic acid (EPA) and arachidonic acid (AA), respectively. Based on substrate availability, these FAs give rise
to different eicosanoid signatures with opposite effects in cancer [4]. ω-3 PUFAs generate both anti-inflammatory
prostanoids and reactive oxygen species (ROS), which in turn could affect NF-κB. Indeed, NF-κB belongs to a family of
transcription factors with a key role in inflammation and oxidative stress, but its role in tumour development is still
controversial [5]. The aim of the study was to determine possible processes that are activated by dietary lipids regulating
BC growth and metastasis. |
format |
conferenceObject |
author |
Vara Messler, Marianela Pasqualini, María Eugenia Comba, Andrea Toniolo, Alicia Trenti, Annalisa Quiroga, Patricia Valentich, Mirta Ana Bolego, Chiara |
author_facet |
Vara Messler, Marianela Pasqualini, María Eugenia Comba, Andrea Toniolo, Alicia Trenti, Annalisa Quiroga, Patricia Valentich, Mirta Ana Bolego, Chiara |
author_sort |
Vara Messler, Marianela |
title |
Effects of ω-3 PUFA-enriched diet on growth parameters in a syngenic murine model of breast adenocarcinoma: a possible role for estrogen receptor alpha |
title_short |
Effects of ω-3 PUFA-enriched diet on growth parameters in a syngenic murine model of breast adenocarcinoma: a possible role for estrogen receptor alpha |
title_full |
Effects of ω-3 PUFA-enriched diet on growth parameters in a syngenic murine model of breast adenocarcinoma: a possible role for estrogen receptor alpha |
title_fullStr |
Effects of ω-3 PUFA-enriched diet on growth parameters in a syngenic murine model of breast adenocarcinoma: a possible role for estrogen receptor alpha |
title_full_unstemmed |
Effects of ω-3 PUFA-enriched diet on growth parameters in a syngenic murine model of breast adenocarcinoma: a possible role for estrogen receptor alpha |
title_sort |
effects of ω-3 pufa-enriched diet on growth parameters in a syngenic murine model of breast adenocarcinoma: a possible role for estrogen receptor alpha |
publishDate |
2022 |
url |
http://hdl.handle.net/11086/22318 |
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