Abolition of the sex difference in Ngn3 by estradiol is depending on sex chromosome complement

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A growing body of evidences indicates that some sexually dimorphic traits cannot be solely explained as a result of gonadal steroid action during the critical period of brain masculinization (E18-PN10). Neurogenin 3 (Ngn3), a gene located in mouse chromosome 10 (MGI:893591), is involved in neuri...

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Autores principales: Tomé, Karina, Cisternas, Carla Daniela, Scerbo Jaureguiberry, Maria Julia, Cambiasso, María Julia
Formato: conferenceObject
Lenguaje:Inglés
Publicado: Universidad Nacional de Córdoba 2022
Materias:
Dimorfismo sexual
Hipotálamo
Neurogénesis
Acceso en línea:http://hdl.handle.net/11086/22176
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R14111086-22176
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Dimorfismo sexual
Hipotálamo
Neurogénesis
spellingShingle Dimorfismo sexual
Hipotálamo
Neurogénesis
Tomé, Karina
Cisternas, Carla Daniela
Scerbo Jaureguiberry, Maria Julia
Cambiasso, María Julia
Abolition of the sex difference in Ngn3 by estradiol is depending on sex chromosome complement
topic_facet Dimorfismo sexual
Hipotálamo
Neurogénesis
description A growing body of evidences indicates that some sexually dimorphic traits cannot be solely explained as a result of gonadal steroid action during the critical period of brain masculinization (E18-PN10). Neurogenin 3 (Ngn3), a gene located in mouse chromosome 10 (MGI:893591), is involved in neuritogenesis and morphological differentiation of hippocampal neurons (Salama-Cohen et al., 2006). Recent works from our laboratory have shown the existence of sex difference in the neuritogenic transcription factor Ngn3 in hypothalamic neurons before brain masculization. Moreover 17β-estradiol (E2) abolishes this sex difference (Scerbo et al., 2014). The sex difference in Ngn3 in hypothalamic neurons is depending on sex chromosome complement (Scerbo et al., 2014). In order to study if cell-autonomous actions of sex chromosomes are involved in the effect of E2 on Ngn3, we evaluated Ngn3 mRNA in neuronal cultures.
format conferenceObject
author Tomé, Karina
Cisternas, Carla Daniela
Scerbo Jaureguiberry, Maria Julia
Cambiasso, María Julia
author_facet Tomé, Karina
Cisternas, Carla Daniela
Scerbo Jaureguiberry, Maria Julia
Cambiasso, María Julia
author_sort Tomé, Karina
title Abolition of the sex difference in Ngn3 by estradiol is depending on sex chromosome complement
title_short Abolition of the sex difference in Ngn3 by estradiol is depending on sex chromosome complement
title_full Abolition of the sex difference in Ngn3 by estradiol is depending on sex chromosome complement
title_fullStr Abolition of the sex difference in Ngn3 by estradiol is depending on sex chromosome complement
title_full_unstemmed Abolition of the sex difference in Ngn3 by estradiol is depending on sex chromosome complement
title_sort abolition of the sex difference in ngn3 by estradiol is depending on sex chromosome complement
publisher Universidad Nacional de Córdoba
publishDate 2022
url http://hdl.handle.net/11086/22176
work_keys_str_mv AT tomekarina abolitionofthesexdifferenceinngn3byestradiolisdependingonsexchromosomecomplement
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