Expression of key steroidogenic enzymes in developing brain: hormonal compensation of sex chromosomes-induced sex differences

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Developing brain of mammals is organized by gonadal steroids during the critical period of sexual differentiation (E18-PN10). The regulatory role of neurosteroids in the early brain is unclear. It is known that 17-β-estradiol (E2) is produced within the brain itself primarily due to local aromatizat...

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Autores principales: Cisternas, Carla Daniela, Tomé, Karina, Cambiasso, María Julia
Formato: conferenceObject
Lenguaje:Inglés
Publicado: 2021
Materias:
Aromatasa
Cerebro
Cromosomas
Acceso en línea:http://hdl.handle.net/11086/21946
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R14111086-21946
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Aromatasa
Cerebro
Cromosomas
spellingShingle Aromatasa
Cerebro
Cromosomas
Cisternas, Carla Daniela
Tomé, Karina
Cambiasso, María Julia
Expression of key steroidogenic enzymes in developing brain: hormonal compensation of sex chromosomes-induced sex differences
topic_facet Aromatasa
Cerebro
Cromosomas
description Developing brain of mammals is organized by gonadal steroids during the critical period of sexual differentiation (E18-PN10). The regulatory role of neurosteroids in the early brain is unclear. It is known that 17-β-estradiol (E2) is produced within the brain itself primarily due to local aromatization of gonadal testosterone and also due to de novo synthesis from cholesterol. Little is known about the circulating and local levels of steroids in the embryonic brain. Thus, the use of animal models that dissociate the effect of gonadal sex from sex chromosomes heritage facilitates the study of organizational actions of gonadal steroids and neurosteroids in each sex.
format conferenceObject
author Cisternas, Carla Daniela
Tomé, Karina
Cambiasso, María Julia
author_facet Cisternas, Carla Daniela
Tomé, Karina
Cambiasso, María Julia
author_sort Cisternas, Carla Daniela
title Expression of key steroidogenic enzymes in developing brain: hormonal compensation of sex chromosomes-induced sex differences
title_short Expression of key steroidogenic enzymes in developing brain: hormonal compensation of sex chromosomes-induced sex differences
title_full Expression of key steroidogenic enzymes in developing brain: hormonal compensation of sex chromosomes-induced sex differences
title_fullStr Expression of key steroidogenic enzymes in developing brain: hormonal compensation of sex chromosomes-induced sex differences
title_full_unstemmed Expression of key steroidogenic enzymes in developing brain: hormonal compensation of sex chromosomes-induced sex differences
title_sort expression of key steroidogenic enzymes in developing brain: hormonal compensation of sex chromosomes-induced sex differences
publishDate 2021
url http://hdl.handle.net/11086/21946
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AT tomekarina expressionofkeysteroidogenicenzymesindevelopingbrainhormonalcompensationofsexchromosomesinducedsexdifferences
AT cambiassomariajulia expressionofkeysteroidogenicenzymesindevelopingbrainhormonalcompensationofsexchromosomesinducedsexdifferences
bdutipo_str Repositorios
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