How glycobiology can help us treat and beat the COVID-19 pandemic
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) emerged during the last months of 2019, spreading throughout the world as a highly transmissible infectious illness designated as COVID-19. Vaccines have now appeared, but the challenges in producing sufficient material and distributing the...
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| Formato: | article |
| Lenguaje: | Inglés |
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2021
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| Acceso en línea: | http://hdl.handle.net/11086/20041 https://www.jbc.org/article/S0021-9258(21)00147-2/fulltext |
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I10-R14111086-20041 |
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dspace |
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Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-141 |
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Repositorio Digital Universitario (UNC) |
| language |
Inglés |
| topic |
Covid 19 SARS-CoV-2 Glycobiology Potential therapies FDA - approved drugs Food and Drug Administration |
| spellingShingle |
Covid 19 SARS-CoV-2 Glycobiology Potential therapies FDA - approved drugs Food and Drug Administration Lardone, Ricardo D. Garay, Yohana C. Parodi, Pedro de la Fuente, Sofia Angeloni, Genaro Bravo, Eduardo O. Schmider, Anneke K. Irazoqui, Fernando J. How glycobiology can help us treat and beat the COVID-19 pandemic |
| topic_facet |
Covid 19 SARS-CoV-2 Glycobiology Potential therapies FDA - approved drugs Food and Drug Administration |
| description |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) emerged during the last months of 2019, spreading throughout the world as a highly transmissible infectious illness designated as COVID-19. Vaccines have now appeared, but the challenges in producing sufficient material and distributing them around the world means that effective treatments to limit infection and improve recovery are still urgently needed. This review focuses on the relevance of different glycobiological molecules that could potentially serve as or inspire therapeutic tools during SARS-CoV-2 infection. As such, we highlight the glycobiology of the SARS-CoV-2 infection process, where glycans on viral proteins and on host glycosaminoglycans have critical roles in efficient infection. We also take notice of the glycan-binding proteins involved in the infective capacity of virus and in human defense. In addition, we critically evaluate the glycobiological contribution of candidate drugs for COVID19 therapy such as glycans for vaccines, anti-glycan antibodies, recombinant lectins, lectin inhibitors, glycosidase inhibitors, polysaccharides, and numerous glycosides, emphasizing some opportunities to repurpose FDA-approved drugs. For the nextgeneration drugs suggested here, biotechnological engineering of new probes to block the SARS-CoV-2 infection might be based on the essential glycobiological insight on glycosyltransferases, glycans, glycan-binding proteins, and glycosidases related to this pathology. |
| format |
article |
| author |
Lardone, Ricardo D. Garay, Yohana C. Parodi, Pedro de la Fuente, Sofia Angeloni, Genaro Bravo, Eduardo O. Schmider, Anneke K. Irazoqui, Fernando J. |
| author_facet |
Lardone, Ricardo D. Garay, Yohana C. Parodi, Pedro de la Fuente, Sofia Angeloni, Genaro Bravo, Eduardo O. Schmider, Anneke K. Irazoqui, Fernando J. |
| author_sort |
Lardone, Ricardo D. |
| title |
How glycobiology can help us treat and beat the COVID-19 pandemic |
| title_short |
How glycobiology can help us treat and beat the COVID-19 pandemic |
| title_full |
How glycobiology can help us treat and beat the COVID-19 pandemic |
| title_fullStr |
How glycobiology can help us treat and beat the COVID-19 pandemic |
| title_full_unstemmed |
How glycobiology can help us treat and beat the COVID-19 pandemic |
| title_sort |
how glycobiology can help us treat and beat the covid-19 pandemic |
| publishDate |
2021 |
| url |
http://hdl.handle.net/11086/20041 https://www.jbc.org/article/S0021-9258(21)00147-2/fulltext |
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