How glycobiology can help us treat and beat the COVID-19 pandemic

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged during the last months of 2019, spreading throughout the world as a highly transmissible infectious illness designated as COVID-19. Vaccines have now appeared, but the challenges in producing sufficient material and distributing th...

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Autores principales:	Lardone, Ricardo Dante, Garay, Yohana Camila, Parodi, Pedro, de la Fuente, Sofia, Angeloni, Genaro, Bravo, Eduardo O., Schmider, Anneke K., Irazoqui, Fernando José
Formato:	article
Lenguaje:	Inglés
Publicado:	2021
Materias:	Covid 19 SARS-CoV-2 Glycobiology Potential therapies FDA-approved drugs
Acceso en línea:	http://hdl.handle.net/11086/19354 https://www.sciencedirect.com/science/article/pii/S0021925821001472
Aporte de:	Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba

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institution	Universidad Nacional de Córdoba
institution_str	I-10
repository_str	R-141
collection	Repositorio Digital Universitario (UNC)
language	Inglés
topic	Covid 19 SARS-CoV-2 Glycobiology Potential therapies FDA-approved drugs
spellingShingle	Covid 19 SARS-CoV-2 Glycobiology Potential therapies FDA-approved drugs Lardone, Ricardo Dante Garay, Yohana Camila Parodi, Pedro de la Fuente, Sofia Angeloni, Genaro Bravo, Eduardo O. Schmider, Anneke K. Irazoqui, Fernando José How glycobiology can help us treat and beat the COVID-19 pandemic
topic_facet	Covid 19 SARS-CoV-2 Glycobiology Potential therapies FDA-approved drugs
description	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged during the last months of 2019, spreading throughout the world as a highly transmissible infectious illness designated as COVID-19. Vaccines have now appeared, but the challenges in producing sufficient material and distributing them around the world means that effective treatments to limit infection and improve recovery are still urgently needed. This review focuses on the relevance of different glycobiological molecules that could potentially serve as or inspire therapeutic tools during SARS-CoV-2 infection. As such, we highlight the glycobiology of the SARS-CoV-2 infection process, where glycans on viral proteins and on host glycosaminoglycans have critical roles in efficient infection. We also take notice of the glycan-binding proteins involved in the infective capacity of virus and in human defense. In addition, we critically evaluate the glycobiological contribution of candidate drugs for COVID-19 therapy such as glycans for vaccines, anti-glycan antibodies, recombinant lectins, lectin inhibitors, glycosidase inhibitors, polysaccharides, and numerous glycosides, emphasizing some opportunities to repurpose FDA-approved drugs. For the next-generation drugs suggested here, biotechnological engineering of new probes to block the SARS-CoV-2 infection might be based on the essential glycobiological insight on glycosyltransferases, glycans, glycan-binding proteins, and glycosidases related to this pathology.
format	article
author	Lardone, Ricardo Dante Garay, Yohana Camila Parodi, Pedro de la Fuente, Sofia Angeloni, Genaro Bravo, Eduardo O. Schmider, Anneke K. Irazoqui, Fernando José
author_facet	Lardone, Ricardo Dante Garay, Yohana Camila Parodi, Pedro de la Fuente, Sofia Angeloni, Genaro Bravo, Eduardo O. Schmider, Anneke K. Irazoqui, Fernando José
author_sort	Lardone, Ricardo Dante
title	How glycobiology can help us treat and beat the COVID-19 pandemic
title_short	How glycobiology can help us treat and beat the COVID-19 pandemic
title_full	How glycobiology can help us treat and beat the COVID-19 pandemic
title_fullStr	How glycobiology can help us treat and beat the COVID-19 pandemic
title_full_unstemmed	How glycobiology can help us treat and beat the COVID-19 pandemic
title_sort	how glycobiology can help us treat and beat the covid-19 pandemic
publishDate	2021
url	http://hdl.handle.net/11086/19354 https://www.sciencedirect.com/science/article/pii/S0021925821001472
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How glycobiology can help us treat and beat the COVID-19 pandemic

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