Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability

Mitochondria serve multiple key cellular functions, including energy generation, redox balance, and regulation of apoptotic cell death, thus making a major impact on healthy and diseased states. Increasingly recognized is that biological network stability/instability can play critical roles in deter...

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Detalles Bibliográficos
Autores principales:	Kembro, Jackeline Melissa, Cortassa, Sonia, Lloyd, David, Sollott, Steven, Aon, Miguel
Formato:	article
Lenguaje:	Inglés
Publicado:	2020
Materias:	Mitochondria Biophysics Biologia Molecular Chaotic Dynamics Redox perturbations Complex Oscillatory Behavior Lyapunov Exponent Strange Attractors
Acceso en línea:	https://doi.org/10.1038/s41598-018-33582-w http://hdl.handle.net/11086/17032
Aporte de:	Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba

id	I10-R14111086-17032
record_format	dspace
institution	Universidad Nacional de Córdoba
institution_str	I-10
repository_str	R-141
collection	Repositorio Digital Universitario (UNC)
language	Inglés
topic	Mitochondria Biophysics Biologia Molecular Chaotic Dynamics Redox perturbations Complex Oscillatory Behavior Lyapunov Exponent Strange Attractors
spellingShingle	Mitochondria Biophysics Biologia Molecular Chaotic Dynamics Redox perturbations Complex Oscillatory Behavior Lyapunov Exponent Strange Attractors Kembro, Jackeline Melissa Cortassa, Sonia Lloyd, David Sollott, Steven Aon, Miguel Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability
topic_facet	Mitochondria Biophysics Biologia Molecular Chaotic Dynamics Redox perturbations Complex Oscillatory Behavior Lyapunov Exponent Strange Attractors
description	Mitochondria serve multiple key cellular functions, including energy generation, redox balance, and regulation of apoptotic cell death, thus making a major impact on healthy and diseased states. Increasingly recognized is that biological network stability/instability can play critical roles in determining health and disease. We report for the first-time mitochondrial chaotic dynamics, characterizing the conditions leading from stability to chaos in this organelle. Using an experimentally validated computational model of mitochondrial function, we show that complex oscillatory dynamics in key metabolic variables, arising at the “edge” between fully functional and pathological behavior, sets the stage for chaos. Under these conditions, a mild, regular sinusoidal redox forcing perturbation triggers chaotic dynamics with main signature traits such as sensitivity to initial conditions, positive Lyapunov exponents, and strange attractors. At the “edge” mitochondrial chaos is exquisitely sensitive to the antioxidant capacity of matrix Mn superoxide dismutase as well as to the amplitude and frequency of the redox perturbation. These results have potential implications both for mitochondrial signaling determining health maintenance, and pathological transformation, including abnormal cardiac rhythms.
format	article
author	Kembro, Jackeline Melissa Cortassa, Sonia Lloyd, David Sollott, Steven Aon, Miguel
author_facet	Kembro, Jackeline Melissa Cortassa, Sonia Lloyd, David Sollott, Steven Aon, Miguel
author_sort	Kembro, Jackeline Melissa
title	Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability
title_short	Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability
title_full	Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability
title_fullStr	Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability
title_full_unstemmed	Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability
title_sort	mitochondrial chaotic dynamics: redox-energetic behavior at the edge of stability
publishDate	2020
url	https://doi.org/10.1038/s41598-018-33582-w http://hdl.handle.net/11086/17032
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bdutipo_str	Repositorios
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Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability

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