Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.013 mM

Analytical methods. Numerical integration of the ME-R model equations was performed with MatCont 2.4 in MATLAB 7.1, until steady-state solutions were obtained (i.e., when the magnitude of each time derivative was -10). Time series with duration of at least 6e6 ms were constructed by numerical integr...

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Detalles Bibliográficos
Autores principales:	Kembro, Jackeline Melissa, Cortassa, Sonia, Lloyd, David, Sollott, Steven, Aon, Miguel
Formato:	workingPaper
Lenguaje:	Inglés
Publicado:	2020
Materias:	Mitochondria- bioenergetics model Oxidative stress effect Oxidative stress factors Oscilaciones Signaling Respiration Superoxide dismutase activity Oxidative stress enzymes Time series Biologia Molecular
Acceso en línea:	https://doi.org/10.6084/m9.figshare.7117808.v1 http://hdl.handle.net/11086/17029
Aporte de:	Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba

id	I10-R14111086-17029
record_format	dspace
institution	Universidad Nacional de Córdoba
institution_str	I-10
repository_str	R-141
collection	Repositorio Digital Universitario (UNC)
language	Inglés
topic	Mitochondria- bioenergetics model Oxidative stress effect Oxidative stress factors Oscilaciones Signaling Respiration Superoxide dismutase activity Oxidative stress enzymes Time series Biologia Molecular
spellingShingle	Mitochondria- bioenergetics model Oxidative stress effect Oxidative stress factors Oscilaciones Signaling Respiration Superoxide dismutase activity Oxidative stress enzymes Time series Biologia Molecular Kembro, Jackeline Melissa Cortassa, Sonia Lloyd, David Sollott, Steven Aon, Miguel Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.013 mM
topic_facet	Mitochondria- bioenergetics model Oxidative stress effect Oxidative stress factors Oscilaciones Signaling Respiration Superoxide dismutase activity Oxidative stress enzymes Time series Biologia Molecular
description	Analytical methods. Numerical integration of the ME-R model equations was performed with MatCont 2.4 in MATLAB 7.1, until steady-state solutions were obtained (i.e., when the magnitude of each time derivative was -10). Time series with duration of at least 6e6 ms were constructed by numerical integration of model equations. To allow transient states to vanish, the system was computed during a time lapse of 2 e8 ms. All studies were performed using the parameter setting optimized in our previous work (Kembro et al. 2013. Biophys J 104(2):332-343; Kembro et al., 2014. Front Physiol 5:257), with ADPm = 0.01mM, i.e. consistent with energized mitochondria under state 4 respiration. The two .txt file represents the time reference and the time series of variables output of the model, in order from left to right column: 1) Mitochondrial Ca+;2) Mitochondrial ADP; 3) Membrane potential; 4)Mitocondrial NADH; 5) Mitochondrial H+; 6) Mitochondrial Phosfate, Pi; 7) Isocitrate; 8) a-ketoglutarate; 9) Succinyl CoA; 10) Succinate; 11) Fumarate; 12) Malate; 13) Oxaloacetate; 14) NADPH; 15) Mitochondrial superoxide; 16) Extramitochondrial superoxide; 17) Mitochondrial hydrogen peroxide; 18) Extramitochondrial hydrogen peroxide; 19) Mitochondrial GSH; 20) Extramitochondrial GSH; 21)Mitochondrial GSSG; 22) Mitochondrial TrxSH2; 23) ExtramitochondrialTrxSH; 24)Mitochondrial PSSGm; 25) Extramitochondrial PSSG.
format	workingPaper
author	Kembro, Jackeline Melissa Cortassa, Sonia Lloyd, David Sollott, Steven Aon, Miguel
author_facet	Kembro, Jackeline Melissa Cortassa, Sonia Lloyd, David Sollott, Steven Aon, Miguel
author_sort	Kembro, Jackeline Melissa
title	Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.013 mM
title_short	Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.013 mM
title_full	Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.013 mM
title_fullStr	Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.013 mM
title_full_unstemmed	Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.013 mM
title_sort	periodic oscillations in mitochondrial function under oxidative stress. sod2 concentrations of 0.013 mm
publishDate	2020
url	https://doi.org/10.6084/m9.figshare.7117808.v1 http://hdl.handle.net/11086/17029
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bdutipo_str	Repositorios
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Periodic oscillations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.013 mM

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