Angiotensin II involvement in the development and persistence of amphetamine-induced sensitization: Striatal dopamine reuptake implications
Impact Factor: 2023 (2024 update): 2.7
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| Autores principales: | , , , , , , |
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| Otros Autores: | |
| Formato: | publishedVersion article |
| Lenguaje: | Inglés |
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Federation of European Neuroscience Societies
2024
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| Acceso en línea: | http://hdl.handle.net/11086/552953 https://rdu.unc.edu.ar/handle/11086/18306 https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.16312 https://pubmed.ncbi.nlm.nih.gov/38480476/ https://doi.org/10.1111/ejn.16312 |
| Aporte de: |
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I10-R141-11086-552953 |
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dspace |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
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R-141 |
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Repositorio Digital Universitario (UNC) |
| language |
Inglés |
| topic |
Amphetamine AT1-R Dopamine reuptake Locomotor activity Schizophrenia Social interaction |
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Amphetamine AT1-R Dopamine reuptake Locomotor activity Schizophrenia Social interaction Basmadjian, Osvaldo M. Occhieppo, Victoria B. Montemerlo, Antonella E. Rivas, Gustavo A. Rubianes, María D. Baiardi, Gustavo Bregonzio, Claudia Angiotensin II involvement in the development and persistence of amphetamine-induced sensitization: Striatal dopamine reuptake implications |
| topic_facet |
Amphetamine AT1-R Dopamine reuptake Locomotor activity Schizophrenia Social interaction |
| description |
Impact Factor: 2023 (2024 update): 2.7 |
| author2 |
https://orcid.org/0000-0003-2354-6164 |
| author_facet |
https://orcid.org/0000-0003-2354-6164 Basmadjian, Osvaldo M. Occhieppo, Victoria B. Montemerlo, Antonella E. Rivas, Gustavo A. Rubianes, María D. Baiardi, Gustavo Bregonzio, Claudia |
| format |
publishedVersion article |
| author |
Basmadjian, Osvaldo M. Occhieppo, Victoria B. Montemerlo, Antonella E. Rivas, Gustavo A. Rubianes, María D. Baiardi, Gustavo Bregonzio, Claudia |
| author_sort |
Basmadjian, Osvaldo M. |
| title |
Angiotensin II involvement in the development and persistence of amphetamine-induced sensitization: Striatal dopamine reuptake implications |
| title_short |
Angiotensin II involvement in the development and persistence of amphetamine-induced sensitization: Striatal dopamine reuptake implications |
| title_full |
Angiotensin II involvement in the development and persistence of amphetamine-induced sensitization: Striatal dopamine reuptake implications |
| title_fullStr |
Angiotensin II involvement in the development and persistence of amphetamine-induced sensitization: Striatal dopamine reuptake implications |
| title_full_unstemmed |
Angiotensin II involvement in the development and persistence of amphetamine-induced sensitization: Striatal dopamine reuptake implications |
| title_sort |
angiotensin ii involvement in the development and persistence of amphetamine-induced sensitization: striatal dopamine reuptake implications |
| publisher |
Federation of European Neuroscience Societies |
| publishDate |
2024 |
| url |
http://hdl.handle.net/11086/552953 https://rdu.unc.edu.ar/handle/11086/18306 https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.16312 https://pubmed.ncbi.nlm.nih.gov/38480476/ https://doi.org/10.1111/ejn.16312 |
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1806949389967556608 |
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I10-R141-11086-5529532024-07-30T20:12:52Z Angiotensin II involvement in the development and persistence of amphetamine-induced sensitization: Striatal dopamine reuptake implications Basmadjian, Osvaldo M. Occhieppo, Victoria B. Montemerlo, Antonella E. Rivas, Gustavo A. Rubianes, María D. Baiardi, Gustavo Bregonzio, Claudia https://orcid.org/0000-0003-2354-6164 https://orcid.org/0000-0002-9325-3458 https://orcid.org/0000-0001-5665-2380 https://orcid.org/0000-0001-7411-6821 https://orcid.org/0000-0003-0729-7401 https://orcid.org/0000-0003-3542-2177 Amphetamine AT1-R Dopamine reuptake Locomotor activity Schizophrenia Social interaction Impact Factor: 2023 (2024 update): 2.7 info:eu-repo/semantics/publishedVersion Fil: Basmadjian, Osvaldo M. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. Fil: Basmadjian, Osvaldo M. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina. Fil: Occhieppo, Victoria B. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. Fil: Occhieppo, Victoria B. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina. Fil: Montemerlo, Antonella E. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina. Fil: Montemerlo, Antonella E. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Físico-Química de Córdoba; Argentina. Fil: Rivas, Gustavo A. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina. Fil: Rivas, Gustavo A. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Físico-Química de Córdoba; Argentina. Fil: Rubianes, María D. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina. Fil: Rubianes, María D. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Físico-Química de Córdoba; Argentina. Fil: Baiardi, Gustavo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Laboratorio de Neurofarmacología; Argentina. Fil: Baiardi, Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Fil: Bregonzio, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina. Fil: Bregonzio, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina. Amphetamine (AMPH) exposure induces behavioural and neurochemical sensitization observed in rodents as hyperlocomotion and increased dopamine release in response to a subsequent dose. Brain Angiotensin II modulates dopaminergic neurotransmission through its AT1 receptors (AT1-R), positively regulating striatal dopamine synthesis and release. This work aims to evaluate the AT1-R role in the development and maintenance of AMPH-induced sensitization. Also, the AT1-R involvement in striatal dopamine reuptake was analysed. The sensitization protocol consisted of daily AMPH administration for 5 days and tested 21 days after withdrawal. An AT1-R antagonist, candesartan, was administered before or after AMPH exposure to evaluate the participation of AT1-R in the development and maintenance of sensitization, respectively. Sensitization was evaluated by locomotor activity and c-Fos immunostaining. Changes in dopamine reuptake kinetics were evaluated 1 day after AT1-R blockade withdrawal treatment, with or without the addition of AMPH in vitro. The social interaction test was performed as another behavioural output. Repeated AMPH exposure induced behavioural and neurochemical sensitization, which was prevented and reversed by candesartan. The AT1-R blockade increased the dopamine reuptake kinetics. Neither the AMPH administration nor the AT1-R blockade altered the performance of social interaction. Our results highlight the AT1-R's crucial role in AMPH sensitization. The enhancement of dopamine reuptake kinetics induced by the AT1-R blockade might attenuate the neuroadaptive changes that lead to AMPH sensitization and its self-perpetuation. Therefore, AT1-R is a prominent candidate as a target for pharmacological treatment of pathologies related to dopamine imbalance, including drug addiction and schizophrenia. Datos de investigación. Todos los datos en los que se basan los resultados están plenamente disponibles en https://rdu.unc.edu.ar/handle/11086/18306 info:eu-repo/semantics/publishedVersion Fil: Basmadjian, Osvaldo M. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. Fil: Basmadjian, Osvaldo M. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina. Fil: Occhieppo, Victoria B. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. Fil: Occhieppo, Victoria B. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina. Fil: Montemerlo, Antonella E. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina. Fil: Montemerlo, Antonella E. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Físico-Química de Córdoba; Argentina. Fil: Rivas, Gustavo A. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina. Fil: Rivas, Gustavo A. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Físico-Química de Córdoba; Argentina. Fil: Rubianes, María D. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina. Fil: Rubianes, María D. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Físico-Química de Córdoba; Argentina. Fil: Baiardi, Gustavo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Laboratorio de Neurofarmacología; Argentina. Fil: Baiardi, Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Fil: Bregonzio, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina. Fil: Bregonzio, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina. 2024-07-29T16:20:00Z 2024-07-29T16:20:00Z 2024-05-21 article Basmadjian, O. M., Occhieppo, V. B., Montemerlo, A. E., Rivas, G. A., Rubianes, M. D., Baiardi, G., &Bregonzio, C. (2024). Angiotensin II involvement in the development and persistence of amphetamine‐induced sensitization: Striatal dopamine reuptake implications. European Journal of Neuroscience, 59(10), 2450-2464. http://hdl.handle.net/11086/552953 1460-9568 https://rdu.unc.edu.ar/handle/11086/18306 https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.16312 https://pubmed.ncbi.nlm.nih.gov/38480476/ https://doi.org/10.1111/ejn.16312 eng Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Federation of European Neuroscience Societies |