Neuronal degeneration in mice induced by an epidemic strain of Saint Louis Encephalitis virus isolated in Argentina
11 p.
| Autores principales: | , , , , , , , |
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| Formato: | publishedVersion article |
| Lenguaje: | Inglés |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/11086/549377 |
| Aporte de: |
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I10-R141-11086-549377 |
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| record_format |
dspace |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-141 |
| collection |
Repositorio Digital Universitario (UNC) |
| language |
Inglés |
| topic |
Saint Louis Encephalitis Virus Neurotropic Arbovirus Encephalitis Neurodegeneration Apoptosis |
| spellingShingle |
Saint Louis Encephalitis Virus Neurotropic Arbovirus Encephalitis Neurodegeneration Apoptosis Rivarola, María Elisa de Olmos, Soledad Albrieu Llinás, Guillermo Tauro, Laura Beatríz Gorosito-Serran, Melisa Konigheim, Brenda Gruppi, Adriana Contigiani, Marta Neuronal degeneration in mice induced by an epidemic strain of Saint Louis Encephalitis virus isolated in Argentina |
| topic_facet |
Saint Louis Encephalitis Virus Neurotropic Arbovirus Encephalitis Neurodegeneration Apoptosis |
| description |
11 p. |
| format |
publishedVersion article |
| author |
Rivarola, María Elisa de Olmos, Soledad Albrieu Llinás, Guillermo Tauro, Laura Beatríz Gorosito-Serran, Melisa Konigheim, Brenda Gruppi, Adriana Contigiani, Marta |
| author_facet |
Rivarola, María Elisa de Olmos, Soledad Albrieu Llinás, Guillermo Tauro, Laura Beatríz Gorosito-Serran, Melisa Konigheim, Brenda Gruppi, Adriana Contigiani, Marta |
| author_sort |
Rivarola, María Elisa |
| title |
Neuronal degeneration in mice induced by an epidemic strain of Saint Louis Encephalitis virus isolated in Argentina |
| title_short |
Neuronal degeneration in mice induced by an epidemic strain of Saint Louis Encephalitis virus isolated in Argentina |
| title_full |
Neuronal degeneration in mice induced by an epidemic strain of Saint Louis Encephalitis virus isolated in Argentina |
| title_fullStr |
Neuronal degeneration in mice induced by an epidemic strain of Saint Louis Encephalitis virus isolated in Argentina |
| title_full_unstemmed |
Neuronal degeneration in mice induced by an epidemic strain of Saint Louis Encephalitis virus isolated in Argentina |
| title_sort |
neuronal degeneration in mice induced by an epidemic strain of saint louis encephalitis virus isolated in argentina |
| publishDate |
2023 |
| url |
http://hdl.handle.net/11086/549377 |
| work_keys_str_mv |
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| _version_ |
1806949807530442752 |
| spelling |
I10-R141-11086-5493772023-12-06T13:07:29Z Neuronal degeneration in mice induced by an epidemic strain of Saint Louis Encephalitis virus isolated in Argentina Rivarola, María Elisa de Olmos, Soledad Albrieu Llinás, Guillermo Tauro, Laura Beatríz Gorosito-Serran, Melisa Konigheim, Brenda Gruppi, Adriana Contigiani, Marta Saint Louis Encephalitis Virus Neurotropic Arbovirus Encephalitis Neurodegeneration Apoptosis 11 p. info:eu-repo/semantics/publishedVersion Fil: de Olmos, Soledad. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Laboratorio de Neuroanatomía e Histología Experimental; Argentina. Fil: de Olmos, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Laboratorio de Neuroanatomía e Histología Experimental; Argentina. Fil: Albrieu Llinás, Guillermo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J.M Vanella". Laboratorio de Arbovirus; Argentina. Fil: Rivarola, María Elisa. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J.M Vanella". Laboratorio de Arbovirus; Argentina. Fil: Tauro, Laura Beatríz . Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Fil: Gorosito-Serran, Melisa. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica. Inmunología; Argentina. Fil: Gruppi, Adriana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica. Inmunología; Argentina. Fil: Contigiani, Marta. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J.M Vanella". Laboratorio de Arbovirus; Argentina. Saint Louis encephalitis virus (SLEV) is a neglected flavivirus that causes severe neurological disorders. The epidemic strain of SLEV, CbaAr-4005, isolated during an outbreak in Córdoba city (Argentina), causes meningitis and encephalitis associated with neurological symptoms in a murine experimental model. Here, we identified the affected brain areas and the damage triggered by this neurotropic arbovirus. We performed a detailed analysis of brain neurodegeneration associated with CbaAr-4005 SLEV infection in mice. The motor cortex, corpus striatum and cerebellum were the most affected structures. Neurodegeneration was also found in the olfactory bulb, thalamus, hypothalamus, hippocampus, and hindbrain. SLEV infection triggered brain cell apoptosis as well as somatodendritic and terminal degeneration. In addition, we observed massive excitotoxic-like degeneration in many cortical structures. Apoptosis was also detected in the neuroblastoma cell line N2a cultured with SLEV. The results evidenced that SLEV CbaAr-4005 infection induced severe degenerative alterations within the central nervous system of infected mice, providing new information about the targets of this flavivirus infection. https://www.frontiersin.org/journals/microbiology info:eu-repo/semantics/publishedVersion Fil: de Olmos, Soledad. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Laboratorio de Neuroanatomía e Histología Experimental; Argentina. Fil: de Olmos, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Laboratorio de Neuroanatomía e Histología Experimental; Argentina. Fil: Albrieu Llinás, Guillermo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J.M Vanella". Laboratorio de Arbovirus; Argentina. Fil: Rivarola, María Elisa. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J.M Vanella". Laboratorio de Arbovirus; Argentina. Fil: Tauro, Laura Beatríz . Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Fil: Gorosito-Serran, Melisa. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica. Inmunología; Argentina. Fil: Gruppi, Adriana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica. Inmunología; Argentina. Fil: Contigiani, Marta. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. J.M Vanella". Laboratorio de Arbovirus; Argentina. Virología 2023-10-05T19:13:14Z 2023-10-05T19:13:14Z 2018 article 1664-302X http://hdl.handle.net/11086/549377 eng Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ Impreso; Electrónico y/o Digital |