Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death

Fil: Hoffiz, Yarely C. Georgia State University; Estados Unidos.

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Detalles Bibliográficos
Autores principales: Hoffiz, Yareley C., Castillo-Ruiz, Alexandra, Hall, Megan A. L., Hite, Taylor A., Gray, Jennifer M., Cisternas, Carla D., Cortes, Laura R, Jacobs, Andrew J., Forger, Nancy G.
Otros Autores: https://orcid.org/0000-0003-4269-3725
Formato: publishedVersion article
Lenguaje:Inglés
Publicado: 2023
Materias:
Vasopressin
Vaginal birth
Cesarean section
Neural activation
Acceso en línea:http://hdl.handle.net/11086/549295
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R141-11086-549295
record_format dspace
spelling I10-R141-11086-5492952023-10-04T06:33:14Z Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death Hoffiz, Yareley C. Castillo-Ruiz, Alexandra Hall, Megan A. L. Hite, Taylor A. Gray, Jennifer M. Cisternas, Carla D. Cortes, Laura R Jacobs, Andrew J. Forger, Nancy G. https://orcid.org/0000-0003-4269-3725 https://orcid.org/0000-0002-6503-1700 https://orcid.org/0000-0002-7777-718X https://orcid.org/0000-0002-6497-9479 https://orcid.org/0000-0003-4574-1307 Vasopressin Vaginal birth Cesarean section Neural activation info:eu-repo/semantics/publishedVersion Fil: Hoffiz, Yarely C. Georgia State University; Estados Unidos. Fil: Castillo Ruiz, Alexandra. Georgia State University; Estados Unidos. Fil: Hall, Megan A. L. Georgia State University; Estados Unidos. Fil: Hite, Taylor A. Georgia State University; Estados Unidos. Fil: Gray, Jennifer M. Georgia State University; Estados Unidos. Fil: Cisternas, Carla Daniela. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina. Fil: Cisternas, Carla Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Fil: Cortes, Laura R. Georgia State University; Estados Unidos. Fil: Jacobs, Andrew J. Georgia State University; Estados Unidos. Fil: Forger, Nancy G.Georgia State University; Estados Unidos. Long-standing clinical findings report a dramatic surge of vasopressin in umbilical cord blood of the human neonate, but the neural underpinnings and function(s) of this phenomenon remain obscure. We studied neural activation in perinatal mice and rats, and found that birth triggers activation of the suprachiasmatic, supraoptic, and paraventricular nuclei of the hypothalamus. This was seen whether mice were born vaginally or via Cesarean section (C-section), and when birth timing was experimentally manipulated. Neuronal phenotyping showed that the activated neurons were predominantly vasopressinergic, and vasopressin mRNA increased fivefold in the hypothalamus during the 2?3 days before birth. Copeptin, a surrogate marker of vasopressin, was elevated 30-to 50-fold in plasma of perinatal mice, with higher levels after a vaginal than a C-section birth. We also found an acute decrease in plasma osmolality after a vaginal, but not C-section birth, suggesting that the difference in vasopressin release between birth modes is functionally meaningful. When vasopressin was administered centrally to newborns, we found an ~ 50% reduction in neuronal cell death in specific brain areas. Collectively, our results identify a conserved neuroendocrine response to birth that is sensitive to birth mode, and influences peripheral physiology and neurodevelopment. https://rdcu.be/ceibH info:eu-repo/semantics/publishedVersion Fil: Hoffiz, Yarely C. Georgia State University; Estados Unidos. Fil: Castillo Ruiz, Alexandra. Georgia State University; Estados Unidos. Fil: Hall, Megan A. L. Georgia State University; Estados Unidos. Fil: Hite, Taylor A. Georgia State University; Estados Unidos. Fil: Gray, Jennifer M. Georgia State University; Estados Unidos. Fil: Cisternas, Carla Daniela. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina. Fil: Cisternas, Carla Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Fil: Cortes, Laura R. Georgia State University; Estados Unidos. Fil: Jacobs, Andrew J. Georgia State University; Estados Unidos. Fil: Forger, Nancy G.Georgia State University; Estados Unidos. Otras Ciencias de la Salud 2023-10-03T15:47:02Z 2023-10-03T15:47:02Z 2021 article 2045-2322 http://hdl.handle.net/11086/549295 eng Attribution-NonCommercial-ShareAlike 4.0 International https://creativecommons.org/licenses/by-nc-sa/4.0/ Electrónico y/o Digital
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Vasopressin
Vaginal birth
Cesarean section
Neural activation
spellingShingle Vasopressin
Vaginal birth
Cesarean section
Neural activation
Hoffiz, Yareley C.
Castillo-Ruiz, Alexandra
Hall, Megan A. L.
Hite, Taylor A.
Gray, Jennifer M.
Cisternas, Carla D.
Cortes, Laura R
Jacobs, Andrew J.
Forger, Nancy G.
Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
topic_facet Vasopressin
Vaginal birth
Cesarean section
Neural activation
description Fil: Hoffiz, Yarely C. Georgia State University; Estados Unidos.
author2 https://orcid.org/0000-0003-4269-3725
author_facet https://orcid.org/0000-0003-4269-3725
Hoffiz, Yareley C.
Castillo-Ruiz, Alexandra
Hall, Megan A. L.
Hite, Taylor A.
Gray, Jennifer M.
Cisternas, Carla D.
Cortes, Laura R
Jacobs, Andrew J.
Forger, Nancy G.
format publishedVersion
article
author Hoffiz, Yareley C.
Castillo-Ruiz, Alexandra
Hall, Megan A. L.
Hite, Taylor A.
Gray, Jennifer M.
Cisternas, Carla D.
Cortes, Laura R
Jacobs, Andrew J.
Forger, Nancy G.
author_sort Hoffiz, Yareley C.
title Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
title_short Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
title_full Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
title_fullStr Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
title_full_unstemmed Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
title_sort birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death
publishDate 2023
url http://hdl.handle.net/11086/549295
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