Alteration of salivary amylase concentration in submandibular gland of wistar rats by the effect of Bevacizumab, 5- Fluorouracil and Oxaliplatin

Fil: Dubersarsky, Claudio Gastón. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Fisiología; Argentina.

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Detalles Bibliográficos
Autores principales: Dubersarsky, Claudio Gastón, Bachmeier, Evelin, Wietz, Fernando Martí, Ferreyra Mariani, Emma Gloria, Migueles Goitea, María Elena, Brunotto, Mabel, Mazzeo, Marcelo Adrián
Formato: conferenceObject
Lenguaje:Inglés
Publicado: Sociedad Argentina de Investigación Odontológica 2023
Materias:
Bevacizumab
Oxaliplatin
Amylases
Acceso en línea:http://hdl.handle.net/11086/548623
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R141-11086-548623
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Bevacizumab
Oxaliplatin
Amylases
spellingShingle Bevacizumab
Oxaliplatin
Amylases
Dubersarsky, Claudio Gastón
Bachmeier, Evelin
Wietz, Fernando Martí
Ferreyra Mariani, Emma Gloria
Migueles Goitea, María Elena
Brunotto, Mabel
Mazzeo, Marcelo Adrián
Alteration of salivary amylase concentration in submandibular gland of wistar rats by the effect of Bevacizumab, 5- Fluorouracil and Oxaliplatin
topic_facet Bevacizumab
Oxaliplatin
Amylases
description Fil: Dubersarsky, Claudio Gastón. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Fisiología; Argentina.
format conferenceObject
author Dubersarsky, Claudio Gastón
Bachmeier, Evelin
Wietz, Fernando Martí
Ferreyra Mariani, Emma Gloria
Migueles Goitea, María Elena
Brunotto, Mabel
Mazzeo, Marcelo Adrián
author_facet Dubersarsky, Claudio Gastón
Bachmeier, Evelin
Wietz, Fernando Martí
Ferreyra Mariani, Emma Gloria
Migueles Goitea, María Elena
Brunotto, Mabel
Mazzeo, Marcelo Adrián
author_sort Dubersarsky, Claudio Gastón
title Alteration of salivary amylase concentration in submandibular gland of wistar rats by the effect of Bevacizumab, 5- Fluorouracil and Oxaliplatin
title_short Alteration of salivary amylase concentration in submandibular gland of wistar rats by the effect of Bevacizumab, 5- Fluorouracil and Oxaliplatin
title_full Alteration of salivary amylase concentration in submandibular gland of wistar rats by the effect of Bevacizumab, 5- Fluorouracil and Oxaliplatin
title_fullStr Alteration of salivary amylase concentration in submandibular gland of wistar rats by the effect of Bevacizumab, 5- Fluorouracil and Oxaliplatin
title_full_unstemmed Alteration of salivary amylase concentration in submandibular gland of wistar rats by the effect of Bevacizumab, 5- Fluorouracil and Oxaliplatin
title_sort alteration of salivary amylase concentration in submandibular gland of wistar rats by the effect of bevacizumab, 5- fluorouracil and oxaliplatin
publisher Sociedad Argentina de Investigación Odontológica
publishDate 2023
url http://hdl.handle.net/11086/548623
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AT wietzfernandomarti alterationofsalivaryamylaseconcentrationinsubmandibularglandofwistarratsbytheeffectofbevacizumab5fluorouracilandoxaliplatin
AT ferreyramarianiemmagloria alterationofsalivaryamylaseconcentrationinsubmandibularglandofwistarratsbytheeffectofbevacizumab5fluorouracilandoxaliplatin
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_version_ 1782014221170507776
spelling I10-R141-11086-5486232023-08-31T18:14:04Z Alteration of salivary amylase concentration in submandibular gland of wistar rats by the effect of Bevacizumab, 5- Fluorouracil and Oxaliplatin Dubersarsky, Claudio Gastón Bachmeier, Evelin Wietz, Fernando Martí Ferreyra Mariani, Emma Gloria Migueles Goitea, María Elena Brunotto, Mabel Mazzeo, Marcelo Adrián Bevacizumab Oxaliplatin Amylases Fil: Dubersarsky, Claudio Gastón. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Fisiología; Argentina. Fil: Bachmeier, Evelin. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Fisiología; Argentina. Fil: Wietz, Fernando Martí, Emma Gloria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Fisiología; Argentina. Fil: Ferreyra Mariani, Emma Gloria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Fisiología; Argentina. Fil: Migueles Goitea, María Elena. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Fisiología; Argentina. Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina. Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Mazzeo, Marcelo Adrián. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Fisiología; Argentina. Objectives: The aim of this study was to determine the concentration of salivary amylase in the submandibular gland (SMG) of Wistar rats treated with Bevacizumab, 5- Fluorouracil and Oxaliplatin.Material and Methods: Forty-eight three-month-old male Wistar rats with body weight (bw) 300/350 grams were used divided into: G1 (control, n: 8), G2 (5-fluorouracil+Leucovorin Calcium, n:8), G3 (Bevacizumab, n:8), G 4 (Oxaliplatin, n:8), G5 (5-Fluorouracil+Leucovorin Calcium+ Bevacizumab+Oxaliplatin, n:8), G6 (paired feeding, no drug, n:8). They received ad libitum feeding, exceptG6, which received the average daily intake of the G5 animals. Doses applied intraperitoneally: G2 (20mg and 10 mg/ kg bw for 5 consecutive days), G3(10 mg/kg bw on days 1 and 15), G4 (8 mg/kg bw on days 1 and 15) and G5 (drugsof G2, G3 and G4 were administered). The animals were fasted, anesthetized, SMG were removed and sacrificed.Salivary amylase concentration was measured by spectrophotometric method. Comparison between groups wasperformed by Analysis of Variance- Tukey test a posteriori, setting p value <0.05 for statistical significance. Protocol approved CICUAL: FCM - FO - UNC. Results: G1 showed a significantly higher salivary amylase concentration in comparison to other groups (137.9 ± 4.64 U/gram of gland) and G2, G4 and G5 had significantly lower average amylase concentration (60,95±4,64, 26.17 ±4.64 and 10.77 ±4.64 U/gram of gland respectively) in relation to G1, G3 and G6. (p=0,0001) .Conclusion: The combined administration of cytostatics and monoclonal antibodies would alterthe functional activity of SMG due to the deleterious action of cytostatic drugs, not due to Bevacizumab. Although the lower intake affected the amylase concentration compared to control group, the effect was significantly greaterdue to the action of the oncological drugs used in the present animal model. Further study on parotid gland will be carried out. https://saio.org.ar/?page_id=104 Fil: Dubersarsky, Claudio Gastón. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Fisiología; Argentina. Fil: Bachmeier, Evelin. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Fisiología; Argentina. Fil: Wietz, Fernando Martí, Emma Gloria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Fisiología; Argentina. Fil: Ferreyra Mariani, Emma Gloria. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Fisiología; Argentina. Fil: Migueles Goitea, María Elena. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Fisiología; Argentina. Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina. Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Mazzeo, Marcelo Adrián. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Fisiología; Argentina. Oncología 2023-08-29T15:57:46Z 2023-08-29T15:57:46Z 2021 conferenceObject 978-987-46399-4-3 http://hdl.handle.net/11086/548623 eng Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ Electrónico y/o Digital Sociedad Argentina de Investigación Odontológica

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