Impairment of glutamate homeostasis in the nucleus accumbens core underpins cross-sensitization to cocaine following chronic restraint stress
Fil: Avalos, María Paula. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina.
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2023
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Acceso en línea: | http://hdl.handle.net/11086/548507 |
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I10-R141-11086-548507 |
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Universidad Nacional de Córdoba |
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R-141 |
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Repositorio Digital Universitario (UNC) |
language |
Inglés |
topic |
Chronic restraint stress Ceftriaxone Cocaine Dendritic spines GLT-1 Glutamate Nucleus accumbens Sensitization https://purl.org/becyt/ford/3 |
spellingShingle |
Chronic restraint stress Ceftriaxone Cocaine Dendritic spines GLT-1 Glutamate Nucleus accumbens Sensitization https://purl.org/becyt/ford/3 Avalos, Maria Paula Bollati, Flavia Andrea Calfa, Gaston Diego Sanchez, Marianela Adela Rigoni, Daiana Esparza, Maria Alejandra Mongi Bragato, Bethania del Carmen Garcia Keller, Constanza Guzman, Andrea Susana Cancela, Liliana Marina Impairment of glutamate homeostasis in the nucleus accumbens core underpins cross-sensitization to cocaine following chronic restraint stress |
topic_facet |
Chronic restraint stress Ceftriaxone Cocaine Dendritic spines GLT-1 Glutamate Nucleus accumbens Sensitization https://purl.org/becyt/ford/3 |
description |
Fil: Avalos, María Paula. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. |
author2 |
https://orcid.org/0000-0003-1358-4298 |
author_facet |
https://orcid.org/0000-0003-1358-4298 Avalos, Maria Paula Bollati, Flavia Andrea Calfa, Gaston Diego Sanchez, Marianela Adela Rigoni, Daiana Esparza, Maria Alejandra Mongi Bragato, Bethania del Carmen Garcia Keller, Constanza Guzman, Andrea Susana Cancela, Liliana Marina |
format |
dataSet |
author |
Avalos, Maria Paula Bollati, Flavia Andrea Calfa, Gaston Diego Sanchez, Marianela Adela Rigoni, Daiana Esparza, Maria Alejandra Mongi Bragato, Bethania del Carmen Garcia Keller, Constanza Guzman, Andrea Susana Cancela, Liliana Marina |
author_sort |
Avalos, Maria Paula |
title |
Impairment of glutamate homeostasis in the nucleus accumbens core underpins cross-sensitization to cocaine following chronic restraint stress |
title_short |
Impairment of glutamate homeostasis in the nucleus accumbens core underpins cross-sensitization to cocaine following chronic restraint stress |
title_full |
Impairment of glutamate homeostasis in the nucleus accumbens core underpins cross-sensitization to cocaine following chronic restraint stress |
title_fullStr |
Impairment of glutamate homeostasis in the nucleus accumbens core underpins cross-sensitization to cocaine following chronic restraint stress |
title_full_unstemmed |
Impairment of glutamate homeostasis in the nucleus accumbens core underpins cross-sensitization to cocaine following chronic restraint stress |
title_sort |
impairment of glutamate homeostasis in the nucleus accumbens core underpins cross-sensitization to cocaine following chronic restraint stress |
publishDate |
2023 |
url |
http://hdl.handle.net/11086/548507 |
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I10-R141-11086-5485072023-08-28T18:49:29Z Impairment of glutamate homeostasis in the nucleus accumbens core underpins cross-sensitization to cocaine following chronic restraint stress Avalos, Maria Paula Bollati, Flavia Andrea Calfa, Gaston Diego Sanchez, Marianela Adela Rigoni, Daiana Esparza, Maria Alejandra Mongi Bragato, Bethania del Carmen Garcia Keller, Constanza Guzman, Andrea Susana Cancela, Liliana Marina https://orcid.org/0000-0003-1358-4298 https://orcid.org/0000-0001-6485-7765 https://orcid.org/0000-0002-8162-7109 https://orcid.org/0000-0001-8008-1856 https://orcid.org/0000-0002-4247-4330 https://orcid.org/0000-0002-0483-5238 https://orcid.org/0000-0002-3141-9571 https://orcid.org/0000-0002-4567-4952 https://orcid.org/0000-0002-5141-0929 Chronic restraint stress Ceftriaxone Cocaine Dendritic spines GLT-1 Glutamate Nucleus accumbens Sensitization https://purl.org/becyt/ford/3 Fil: Avalos, María Paula. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Fil: Cancela, Liliana Marina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. Fil: Cancela, Liliana Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina. Fil: Bollati, Flavia Andrea. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. Fil: Bollati, Flavia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina. Fil: Rigoni, Daiana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Fil: Garcia Keller, Constanza. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Fil: Guzmán, Andrea Susana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Fil: Calfa, Diego Gastón. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Fil: Calfa, Diego Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina. Fil: Sanchez, Marianela Adela. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Fil: Sanchez, Marianela Adela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina. Fil: Esparza, Maria Alejandra. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Fil: Esparza, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina. Fil: Mongi Bragato, Bethania del Carmen. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Fil: Mongi Bragato, Bethania del Carmen. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. Though the facilitating influence of stress on drug abuse is well documented, the mechanisms underlying this interaction have yet to be fully elucidated. The present study explores the neurobiological mechanisms underpinning the sensitized response to the psychomotor-stimulating effects of cocaine following chronic restraint stress (CRS), emphasizing the differential contribution of both subcompartments of the nucleus accumbens (NA), the core (NAcore) and shell (NAshell), to this phenomenon. Adult male Wistar rats were restrained for 2 h/ day for 7 days and, 2 weeks after the last stress exposure (day 21), all animals were randomly assigned to behavioral, biochemical or neurochemical tests. Our results demonstrated that the enduring CRS-induced increase in psychostimulant response to cocaine was paralleled by an increase of extracellular dopamine levels in the NAcore, but not the NAshell, greater than that observed in the non-stress group. Furthermore, we found that CRS induced an impairment of glutamate homeostasis in the NAcore, but not the NAshell. Its hallmarks were increased basal extracellular glutamate concentrations driven by a CRS-induced downregulation of GLT-1, blunted glutamate levels in response to cocaine and postsynaptic structural remodeling in pre-stressed animals. In addition, ceftriaxone, a known GLT-1 enhancer, prevented the CRS-induced GLT-1 downregulation, increased basal extracellular glutamate concentrations and changes in structural plasticity in the NAcore as well as behavioral cross-sensitization to cocaine, emphasizing the biological importance of GLT-1 in the comorbidity between chronic stress exposure and drug abuse. A future perspective concerning the paramount relevance of the stress-induced disruption of glutamate homeostasis as a vulnerability factor to the development of stress and substance use disorders during early life or adulthood of descendants is provided Fil: Avalos, María Paula. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Fil: Cancela, Liliana Marina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. Fil: Cancela, Liliana Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina. Fil: Bollati, Flavia Andrea. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. Fil: Bollati, Flavia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina. Fil: Rigoni, Daiana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Fil: Garcia Keller, Constanza. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Fil: Guzmán, Andrea Susana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Fil: Calfa, Diego Gastón. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Fil: Calfa, Diego Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina. Fil: Sanchez, Marianela Adela. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Fil: Sanchez, Marianela Adela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina. Fil: Esparza, Maria Alejandra. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Fil: Esparza, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina. Fil: Mongi Bragato, Bethania del Carmen. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. Fil: Mongi Bragato, Bethania del Carmen. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. 2023-08-17T19:19:12Z 2023-08-17T19:19:12Z 2022 dataSet http://hdl.handle.net/11086/548507 eng https://rdu.unc.edu.ar/handle/11086/548569 https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |