Differences in T regulatory cells between mouse strains frequently used in immunological research: Treg cell quantities and subpopulations in NOD, B6 and BALB/c mice
Fil: Godoy, Gloria J. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina.
Guardado en:
Autores principales: | , , , , , |
---|---|
Otros Autores: | |
Formato: | publishedVersion article |
Lenguaje: | Inglés |
Publicado: |
European Federation of Immunological Societies
2023
|
Materias: | |
Acceso en línea: | http://hdl.handle.net/11086/548177 https://www.sciencedirect.com/science/article/pii/S0165247819305826 |
Aporte de: |
id |
I10-R141-11086-548177 |
---|---|
record_format |
dspace |
institution |
Universidad Nacional de Córdoba |
institution_str |
I-10 |
repository_str |
R-141 |
collection |
Repositorio Digital Universitario (UNC) |
language |
Inglés |
topic |
NOD mice Regulatory T cells iTregs Naïve and Central memory Tregs Chemokine receptors |
spellingShingle |
NOD mice Regulatory T cells iTregs Naïve and Central memory Tregs Chemokine receptors Godoy, Gloria J. Paira, Daniela A. Olivera, Carolina Breser, Maria L. Sanchez, Leonardo R. Motrich, Rubén D. Differences in T regulatory cells between mouse strains frequently used in immunological research: Treg cell quantities and subpopulations in NOD, B6 and BALB/c mice |
topic_facet |
NOD mice Regulatory T cells iTregs Naïve and Central memory Tregs Chemokine receptors |
description |
Fil: Godoy, Gloria J. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina. |
author2 |
https://orcid.org/0000-0003-1378-9170 |
author_facet |
https://orcid.org/0000-0003-1378-9170 Godoy, Gloria J. Paira, Daniela A. Olivera, Carolina Breser, Maria L. Sanchez, Leonardo R. Motrich, Rubén D. |
format |
publishedVersion article |
author |
Godoy, Gloria J. Paira, Daniela A. Olivera, Carolina Breser, Maria L. Sanchez, Leonardo R. Motrich, Rubén D. |
author_sort |
Godoy, Gloria J. |
title |
Differences in T regulatory cells between mouse strains frequently used in immunological research: Treg cell quantities and subpopulations in NOD, B6 and BALB/c mice |
title_short |
Differences in T regulatory cells between mouse strains frequently used in immunological research: Treg cell quantities and subpopulations in NOD, B6 and BALB/c mice |
title_full |
Differences in T regulatory cells between mouse strains frequently used in immunological research: Treg cell quantities and subpopulations in NOD, B6 and BALB/c mice |
title_fullStr |
Differences in T regulatory cells between mouse strains frequently used in immunological research: Treg cell quantities and subpopulations in NOD, B6 and BALB/c mice |
title_full_unstemmed |
Differences in T regulatory cells between mouse strains frequently used in immunological research: Treg cell quantities and subpopulations in NOD, B6 and BALB/c mice |
title_sort |
differences in t regulatory cells between mouse strains frequently used in immunological research: treg cell quantities and subpopulations in nod, b6 and balb/c mice |
publisher |
European Federation of Immunological Societies |
publishDate |
2023 |
url |
http://hdl.handle.net/11086/548177 https://www.sciencedirect.com/science/article/pii/S0165247819305826 |
work_keys_str_mv |
AT godoygloriaj differencesintregulatorycellsbetweenmousestrainsfrequentlyusedinimmunologicalresearchtregcellquantitiesandsubpopulationsinnodb6andbalbcmice AT pairadanielaa differencesintregulatorycellsbetweenmousestrainsfrequentlyusedinimmunologicalresearchtregcellquantitiesandsubpopulationsinnodb6andbalbcmice AT oliveracarolina differencesintregulatorycellsbetweenmousestrainsfrequentlyusedinimmunologicalresearchtregcellquantitiesandsubpopulationsinnodb6andbalbcmice AT bresermarial differencesintregulatorycellsbetweenmousestrainsfrequentlyusedinimmunologicalresearchtregcellquantitiesandsubpopulationsinnodb6andbalbcmice AT sanchezleonardor differencesintregulatorycellsbetweenmousestrainsfrequentlyusedinimmunologicalresearchtregcellquantitiesandsubpopulationsinnodb6andbalbcmice AT motrichrubend differencesintregulatorycellsbetweenmousestrainsfrequentlyusedinimmunologicalresearchtregcellquantitiesandsubpopulationsinnodb6andbalbcmice |
_version_ |
1782014776260427776 |
spelling |
I10-R141-11086-5481772023-08-30T14:26:59Z Differences in T regulatory cells between mouse strains frequently used in immunological research: Treg cell quantities and subpopulations in NOD, B6 and BALB/c mice Godoy, Gloria J. Paira, Daniela A. Olivera, Carolina Breser, Maria L. Sanchez, Leonardo R. Motrich, Rubén D. https://orcid.org/0000-0003-1378-9170 NOD mice Regulatory T cells iTregs Naïve and Central memory Tregs Chemokine receptors info:eu-repo/semantics/publishedVersion Fil: Godoy, Gloria J. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina. Fil: Godoy, Gloria J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina. Fil: Paira Daniela A. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina. Fil: Paira Daniela A. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina. Fil: Olivera, Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina. Fil: Olivera, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina. Fil: Breser, Maria L. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina. Fil: Breser, Maria L. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina. Fil: Sánchez, Leonardo R. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina. Fil: Sánchez, Leonardo R. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina. Fil: Motrich, Ruben D. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina. Fil: Motrich, Ruben D. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina. Fil: Rivero, Virginia E. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina. Fil: Rivero, Virginia E. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina. Foxp3+ Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self. Therefore, it is expected that lower numbers and/or less than optimal function could impact on the functioning of the immune system, and thereby contributing to the development of autoimmune diseases. In the present report, by comparing Tregs from most frequently used mouse strains in immunological research (C57BL/6 (B6), BALB/c and NOD), we provide evidence showing that the NOD mouse strain, highly predisposed to develop autoimmune responses, exhibit a generalized decreased in Tregs counts with enhanced proportions of CD44hiCD62Llow Tregs when compared with BALB/c mice. No major differences were observed in Helios+ or Helios- Tregs between strains. The expression of CXCR3, CCR5 and CCR6 on Tregs from all strains showed minor proportions of CXCR3+ and CCR5+ cells in NOD Tregs. Naïve CD4+CD25- T cells from NOD mice also showed decreased capacity to induce in vitro iTregs when compared with B6 and BALB/c mice. Lower expression of molecules involved in Treg suppressor mechanisms such as CD25, LAP-1, CD39 and PD-1 was observed both in NOD iTregs and Tregs from lymph nodes of NOD mice. Moreover, in vitro assays showed that Tregs from NOD mice exhibited reduced ability to suppress proliferation of CD4+CD25- responder T cells when compared with B6 and BALB/c mice. Major differences were consistently observed between NOD and BALB/c mice, whereas no major differences were found for many of the analyzed parameters between the NOD and B6 mice, suggesting that highly and mildly autoimmune prone mouse strains may share some Tregs features. On the contrary, BALB/c Tregs were in major quantities, expressed higher levels of Foxp3 and exhibited more potent ability to inhibit effector T cell proliferation, data that could be related to its natural resistance to the induction of different experimental autoimmune conditions. Altogether our results demonstrate a generalized Treg cell dysfunction in NOD mice, a strain characterized by its high predisposition to develop spontaneous and induced autoimmune diseases. info:eu-repo/semantics/publishedVersion Fil: Godoy, Gloria J. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina. Fil: Godoy, Gloria J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina. Fil: Paira Daniela A. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina. Fil: Paira Daniela A. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina. Fil: Olivera, Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina. Fil: Olivera, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina. Fil: Breser, Maria L. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina. Fil: Breser, Maria L. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina. Fil: Sánchez, Leonardo R. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina. Fil: Sánchez, Leonardo R. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina. Fil: Motrich, Ruben D. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina. Fil: Motrich, Ruben D. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina. Fil: Rivero, Virginia E. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina. Fil: Rivero, Virginia E. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina. 2023-07-10T15:30:10Z 2023-07-10T15:30:10Z 2020-07 article Godoy, Gloria Janet; Paira, Daniela Andrea; Olivera, Carolina; Breser, Maria Laura; Sanchez, Leonardo Rodolfo; et al.; Differences in T regulatory cells between mouse strains frequently used in immunological research: Treg cell quantities and subpopulations in NOD, B6 and BALB/c mice; Elsevier Science; Immunology Letters; 223; 7-2020; 17-25. https://doi.org/10.1016/j.imlet.2020.04.006 http://hdl.handle.net/11086/548177 https://www.sciencedirect.com/science/article/pii/S0165247819305826 0165-2478 eng Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ European Federation of Immunological Societies |