Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function
Fil: Kembro, Jackelyn. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina.
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I10-R141-11086-5472172023-08-30T13:56:20Z Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function Kembro, Jackelyn Química biológica Redes mitocondriales reactive oxygen species [ROS] Investigaciones biológicas Fil: Kembro, Jackelyn. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Fil: Kembro, Jackelyn. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Biológica; Argentina. The time-keeping properties bestowed by oscillatory behavior on functional rhythms represent an evolutionarily conserved trait in living systems. Mitochondrial networks function as timekeepers maximizing energetic output while tuning reactive oxygen species [ROS] within physiological levels compatible with signaling. In this work, we explore the potential for timekeeping functions dependent on mitochondrial dynamics with the validated two-compartment mitochondrial energetic-redox (ME-R) computational model, that takes into account (a) four main redox couples (NADH, NADPH, GSH, Trx(SH)2), (b) scavenging systems (glutathione, thioredoxin, SOD, catalase) distributed in matrix and extra-matrix compartments, and (c) transport of ROS species between them. Fil: Kembro, Jackelyn. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Fil: Kembro, Jackelyn. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Biológica; Argentina. Biofísica 2023-04-27T13:00:32Z 2023-04-27T13:00:32Z 2014 conferenceObject http://hdl.handle.net/11086/547217 eng Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ Impreso |
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Universidad Nacional de Córdoba |
institution_str |
I-10 |
repository_str |
R-141 |
collection |
Repositorio Digital Universitario (UNC) |
language |
Inglés |
topic |
Química biológica Redes mitocondriales reactive oxygen species [ROS] Investigaciones biológicas |
spellingShingle |
Química biológica Redes mitocondriales reactive oxygen species [ROS] Investigaciones biológicas Kembro, Jackelyn Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function |
topic_facet |
Química biológica Redes mitocondriales reactive oxygen species [ROS] Investigaciones biológicas |
description |
Fil: Kembro, Jackelyn. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. |
format |
conferenceObject |
author |
Kembro, Jackelyn |
author_facet |
Kembro, Jackelyn |
author_sort |
Kembro, Jackelyn |
title |
Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function |
title_short |
Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function |
title_full |
Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function |
title_fullStr |
Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function |
title_full_unstemmed |
Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function |
title_sort |
complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function |
publishDate |
2023 |
url |
http://hdl.handle.net/11086/547217 |
work_keys_str_mv |
AT kembrojackelyn complexoscillatoryredoxdynamicswithsignalingpotentialattheedgebetweennormalandpathologicalmitochondrialfunction |
_version_ |
1782013926246973440 |