Incidence of the nordihydroguaiaretic acid content on the in vitro antiviral activity of extracts obtained from larrea divaricata cav. (Zygophyllaceae)

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Detalles Bibliográficos
Autores principales:	Konigheim, Brenda S., Aguilar, Juan Javier, Grasso, Sergio, Contigiani, Marta, Nuñez Montoya, Susana C.
Formato:	publishedVersion article
Lenguaje:	Español
Publicado:	2022
Materias:	Virología Larrea divaricata
Acceso en línea:	http://hdl.handle.net/11086/28692
Aporte de:	Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba

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spelling	I10-R141-11086-286922024-05-29T19:10:32Z Incidence of the nordihydroguaiaretic acid content on the in vitro antiviral activity of extracts obtained from larrea divaricata cav. (Zygophyllaceae) Konigheim, Brenda S. Aguilar, Juan Javier Grasso, Sergio Contigiani, Marta Nuñez Montoya, Susana C. Virología Larrea divaricata 6 p. publishedVersion Fil: Konigheim, Brenda S. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Konigheim, Brenda S. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Fil: Aguilar, Juan Javier. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Grasso, Sergio. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia. Instituto Multidisciplinario de Biología Vegetal; Argentina. Fil: Contigiani, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Nuñez Montoya, Susana C. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Nuñez Montoya, Susana C. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia. Instituto Multidisciplinario de Biología Vegetal; Argentina. The South American species Larrea divaricata Cav. (Zygophyllaceae) has been widely used in folk medicine against infectious diseases. In previous studies, we reported that several extracts obtained from the aerial parts of this species and the nordihydroguaiaretic acid (NDGA), its main lignan, inhibited Junin Virus (JUNV) in vitro. In this work, the objective was to assess whether NDGA is truly responsible for the antiviral activity produced by the extracts. Therefore, the presence and amount of NDGA in extracts were determined by HPLC. We established that NDGA in the extracts analyzed is required to inhibit JUNV and observed that some components of the bioactive extracts would increase the antiviral effect of NDGA. On the other hand, we estimated the selectivity index for NDGA against JUNV. Thus, NDGA and extracts containing this lignan exhibited potential therapeutic effects against the etiologic agent of the Argentine Hemorrhagic Fever, an endemo-epidemic illness in this country publishedVersion 2032 Fil: Konigheim, Brenda S. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Konigheim, Brenda S. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Fil: Aguilar, Juan Javier. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Grasso, Sergio. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia. Instituto Multidisciplinario de Biología Vegetal; Argentina. Fil: Contigiani, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Nuñez Montoya, Susana C. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología "Dr. José María Vanella"; Argentina. Fil: Nuñez Montoya, Susana C. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia. Instituto Multidisciplinario de Biología Vegetal; Argentina. Virología 2022-10-05T16:21:54Z 2013 article 0326-2383 http://hdl.handle.net/11086/28692 spa Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ Impreso y/o Electrónico
institution	Universidad Nacional de Córdoba
institution_str	I-10
repository_str	R-141
collection	Repositorio Digital Universitario (UNC)
language	Español
topic	Virología Larrea divaricata
spellingShingle	Virología Larrea divaricata Konigheim, Brenda S. Aguilar, Juan Javier Grasso, Sergio Contigiani, Marta Nuñez Montoya, Susana C. Incidence of the nordihydroguaiaretic acid content on the in vitro antiviral activity of extracts obtained from larrea divaricata cav. (Zygophyllaceae)
topic_facet	Virología Larrea divaricata
description	6 p.
format	publishedVersion article
author	Konigheim, Brenda S. Aguilar, Juan Javier Grasso, Sergio Contigiani, Marta Nuñez Montoya, Susana C.
author_facet	Konigheim, Brenda S. Aguilar, Juan Javier Grasso, Sergio Contigiani, Marta Nuñez Montoya, Susana C.
author_sort	Konigheim, Brenda S.
title	Incidence of the nordihydroguaiaretic acid content on the in vitro antiviral activity of extracts obtained from larrea divaricata cav. (Zygophyllaceae)
title_short	Incidence of the nordihydroguaiaretic acid content on the in vitro antiviral activity of extracts obtained from larrea divaricata cav. (Zygophyllaceae)
title_full	Incidence of the nordihydroguaiaretic acid content on the in vitro antiviral activity of extracts obtained from larrea divaricata cav. (Zygophyllaceae)
title_fullStr	Incidence of the nordihydroguaiaretic acid content on the in vitro antiviral activity of extracts obtained from larrea divaricata cav. (Zygophyllaceae)
title_full_unstemmed	Incidence of the nordihydroguaiaretic acid content on the in vitro antiviral activity of extracts obtained from larrea divaricata cav. (Zygophyllaceae)
title_sort	incidence of the nordihydroguaiaretic acid content on the in vitro antiviral activity of extracts obtained from larrea divaricata cav. (zygophyllaceae)
publishDate	2022
url	http://hdl.handle.net/11086/28692
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Incidence of the nordihydroguaiaretic acid content on the in vitro antiviral activity of extracts obtained from larrea divaricata cav. (Zygophyllaceae)

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