Histone deacetylase gene expression is regulated by sex chromosome complement in the amygdala of the developing mouse brain

Fil: Sosa, Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina.

Guardado en:
Detalles Bibliográficos
Autores principales: Sosa, Camila, Cisternas, Carla Daniela, Conti, Romina Paula, Cambiasso, María Julia
Formato: conferenceObject
Lenguaje:Inglés
Publicado: 2022
Materias:
Sexual differentiation
Androgens
Sex chromosomes
Acceso en línea:http://hdl.handle.net/11086/28254
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R141-11086-28254
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Sexual differentiation
Androgens
Sex chromosomes
spellingShingle Sexual differentiation
Androgens
Sex chromosomes
Sosa, Camila
Cisternas, Carla Daniela
Conti, Romina Paula
Cambiasso, María Julia
Histone deacetylase gene expression is regulated by sex chromosome complement in the amygdala of the developing mouse brain
topic_facet Sexual differentiation
Androgens
Sex chromosomes
description Fil: Sosa, Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina.
format conferenceObject
author Sosa, Camila
Cisternas, Carla Daniela
Conti, Romina Paula
Cambiasso, María Julia
author_facet Sosa, Camila
Cisternas, Carla Daniela
Conti, Romina Paula
Cambiasso, María Julia
author_sort Sosa, Camila
title Histone deacetylase gene expression is regulated by sex chromosome complement in the amygdala of the developing mouse brain
title_short Histone deacetylase gene expression is regulated by sex chromosome complement in the amygdala of the developing mouse brain
title_full Histone deacetylase gene expression is regulated by sex chromosome complement in the amygdala of the developing mouse brain
title_fullStr Histone deacetylase gene expression is regulated by sex chromosome complement in the amygdala of the developing mouse brain
title_full_unstemmed Histone deacetylase gene expression is regulated by sex chromosome complement in the amygdala of the developing mouse brain
title_sort histone deacetylase gene expression is regulated by sex chromosome complement in the amygdala of the developing mouse brain
publishDate 2022
url http://hdl.handle.net/11086/28254
work_keys_str_mv AT sosacamila histonedeacetylasegeneexpressionisregulatedbysexchromosomecomplementintheamygdalaofthedevelopingmousebrain
AT cisternascarladaniela histonedeacetylasegeneexpressionisregulatedbysexchromosomecomplementintheamygdalaofthedevelopingmousebrain
AT contirominapaula histonedeacetylasegeneexpressionisregulatedbysexchromosomecomplementintheamygdalaofthedevelopingmousebrain
AT cambiassomariajulia histonedeacetylasegeneexpressionisregulatedbysexchromosomecomplementintheamygdalaofthedevelopingmousebrain
_version_ 1782014104562565120
spelling I10-R141-11086-282542023-08-31T18:13:57Z Histone deacetylase gene expression is regulated by sex chromosome complement in the amygdala of the developing mouse brain Sosa, Camila Cisternas, Carla Daniela Conti, Romina Paula Cambiasso, María Julia Sexual differentiation Androgens Sex chromosomes Fil: Sosa, Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Fil: Sosa, Camila. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Fil: Cisternas, Carla Daniela. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Biología Celular; Argentina. Fil: Cisternas, Carla Daniela. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Cátedra de Fisiología Animal; Argentina. Fil: Cisternas, Carla Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Fil: Conti, Romina Paula. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Biología Celular; Argentina. Fil: Cambiasso, María Julia. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Biología Celular; Argentina. Fil: Cambiasso, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Sexual differentiation of the rodent brain depends mainly on the action of androgens secreted by the fetal testis during the perinatal critical period (E17-P10). Recently, the role of genetic factors derived from sex chromosome complement has been recognized. Both hormonal and genetic factors interact to induce long lasting effects on sexually dimorphic gene expression. Epigenetic histone modifications have emerged as mechanisms of regulation and maintenance of hormonal-dependent effects in the brain and histone deacetylation induced by histone deacetylases (Hdacs) has recently been implicated in brain masculinization. To analyse the contribution of sex chromosome complement on this process, we evaluated the expression of Class I and II Hdacs in E15 amygdala derived from the ?Four Core Genotypes? mouse model which comprises XX and XY gonadal males and XX and XY gonadal females. The mRNA expression of Class I Hdac1, 2 and 8 as well as Class II Hdac4 and 6 in amygdalae was analyzed by qPCR. Hdac1, 2 and 8 expression levels were higher in amygdala derived from XX embryos compared to XY, irrespectively of gonadal sex. No differences were observed in Hdac4 and 6. Our results suggest that sex chromosomes may determine a sexually dimorphic gene expression through Class I Hdacs in specific areas of the mouse brain before the in utero exposure to gonadal hormones. Current experiments are evaluating candidate genes regulated by Class I Hdacs relevant to sexual differentiation. https://san2020.saneurociencias.org.ar/epostersbytopics/ Fil: Sosa, Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Fil: Sosa, Camila. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Fil: Cisternas, Carla Daniela. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Biología Celular; Argentina. Fil: Cisternas, Carla Daniela. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Cátedra de Fisiología Animal; Argentina. Fil: Cisternas, Carla Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Fil: Conti, Romina Paula. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Biología Celular; Argentina. Fil: Cambiasso, María Julia. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Biología Celular; Argentina. Fil: Cambiasso, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Otras Ciencias de la Salud 2022-08-22T12:34:38Z 2022-08-22T12:34:38Z 2020 conferenceObject http://hdl.handle.net/11086/28254 eng Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ Electrónico y/o Digital

Ejemplares similares