Oral squamous cell carcinoma (OSCC) tumors from heavy alcohol consumers are associated with higher levels of TLR9 and a particular immunophenotype: Impact on patient survival

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Head and neck cancer was identified as the seventh most common cancer worldwide in 2018, with 890,000 new cases and 450,000 deaths being reported. Oral squamous cell carcinoma (OSCC) is the most prevalent subgroup of head and neck cancer and includes the lips, the tongue, the gums, the buccal mucos...

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Autores principales: Bolesina, Nicolás, Gatti, Gerardo, López de Blanc, Silvia, Dhooge, Sabrina, Rocha, Dario, Fernández, Elmer, Ferreyra, Ruth, Palla, Vanesa, Grupe, Verónica, Morelatto, Rosana, Maccioni, Mariana
Formato: article
Lenguaje:Inglés
Publicado: 2022
Materias:
Oral squamous cell carcinoma
Immunophenotype
Alcohol consumption
CD8+T cell infiltration
TLR9
Acceso en línea:http://hdl.handle.net/11086/28229
https://doi.org/10.3389/fimmu.2022.941667
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R141-11086-28229
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Oral squamous cell carcinoma
Immunophenotype
Alcohol consumption
CD8+T cell infiltration
TLR9
spellingShingle Oral squamous cell carcinoma
Immunophenotype
Alcohol consumption
CD8+T cell infiltration
TLR9
Bolesina, Nicolás
Gatti, Gerardo
López de Blanc, Silvia
Dhooge, Sabrina
Rocha, Dario
Fernández, Elmer
Ferreyra, Ruth
Palla, Vanesa
Grupe, Verónica
Morelatto, Rosana
Maccioni, Mariana
Oral squamous cell carcinoma (OSCC) tumors from heavy alcohol consumers are associated with higher levels of TLR9 and a particular immunophenotype: Impact on patient survival
topic_facet Oral squamous cell carcinoma
Immunophenotype
Alcohol consumption
CD8+T cell infiltration
TLR9
description Head and neck cancer was identified as the seventh most common cancer worldwide in 2018, with 890,000 new cases and 450,000 deaths being reported. Oral squamous cell carcinoma (OSCC) is the most prevalent subgroup of head and neck cancer and includes the lips, the tongue, the gums, the buccal mucosa, the floor of the mouth, the hard palate, and the alveolar ridge. It represents a major cause of morbidity and mortality worldwide, especially in Southern Asia and the Pacific islands (2). It arises as a consequence of multifactorial risk factors that include tobacco and alcohol, chronic inflammation, ultraviolet radiation (for lip cancer), human papilloma virus (HPV) or Candida infections, immunosuppression, genetic predisposition, and diet. However, tobacco smoking and alcohol consumption are considered as the main causal factors (3, 4). OSCC is still a leading cause of cancer death among men in many places and despite several advancements in therapeutic approaches, the 5-year survival rate is around 50% (1).
format article
author Bolesina, Nicolás
Gatti, Gerardo
López de Blanc, Silvia
Dhooge, Sabrina
Rocha, Dario
Fernández, Elmer
Ferreyra, Ruth
Palla, Vanesa
Grupe, Verónica
Morelatto, Rosana
Maccioni, Mariana
author_facet Bolesina, Nicolás
Gatti, Gerardo
López de Blanc, Silvia
Dhooge, Sabrina
Rocha, Dario
Fernández, Elmer
Ferreyra, Ruth
Palla, Vanesa
Grupe, Verónica
Morelatto, Rosana
Maccioni, Mariana
author_sort Bolesina, Nicolás
title Oral squamous cell carcinoma (OSCC) tumors from heavy alcohol consumers are associated with higher levels of TLR9 and a particular immunophenotype: Impact on patient survival
title_short Oral squamous cell carcinoma (OSCC) tumors from heavy alcohol consumers are associated with higher levels of TLR9 and a particular immunophenotype: Impact on patient survival
title_full Oral squamous cell carcinoma (OSCC) tumors from heavy alcohol consumers are associated with higher levels of TLR9 and a particular immunophenotype: Impact on patient survival
title_fullStr Oral squamous cell carcinoma (OSCC) tumors from heavy alcohol consumers are associated with higher levels of TLR9 and a particular immunophenotype: Impact on patient survival
title_full_unstemmed Oral squamous cell carcinoma (OSCC) tumors from heavy alcohol consumers are associated with higher levels of TLR9 and a particular immunophenotype: Impact on patient survival
title_sort oral squamous cell carcinoma (oscc) tumors from heavy alcohol consumers are associated with higher levels of tlr9 and a particular immunophenotype: impact on patient survival
publishDate 2022
url http://hdl.handle.net/11086/28229
https://doi.org/10.3389/fimmu.2022.941667
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