Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A

Mostrar todas las versiones(2)

Intracellular transport based on molecular motors and its regulation are crucial to the functioning of cells. Filamentary tracks of the cells are abundantly decorated with nonmotile microtubule-associated proteins, such as tau. Motivated by experiments on kinesin-tau interactions [Dixit et al., Scie...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Sparacino, Javier, Farías, María Gimena, Lamberti, Pedro Walter
Formato: article
Lenguaje:Inglés
Publicado: 2021
Materias:
Motores moleculares
Proteína Tau
Dinámica
Acceso en línea:http://hdl.handle.net/11086/19280
https://doi.org/10.1103/PhysRevE.89.022714
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R141-11086-19280
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic Motores moleculares
Proteína Tau
Dinámica
spellingShingle Motores moleculares
Proteína Tau
Dinámica
Sparacino, Javier
Farías, María Gimena
Lamberti, Pedro Walter
Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A
topic_facet Motores moleculares
Proteína Tau
Dinámica
description Intracellular transport based on molecular motors and its regulation are crucial to the functioning of cells. Filamentary tracks of the cells are abundantly decorated with nonmotile microtubule-associated proteins, such as tau. Motivated by experiments on kinesin-tau interactions [Dixit et al., Science 319, 1086 (2008)] we developed a stochastic model of interacting single-headed motor proteins KIF1A that also takes into account the interactions between motor proteins and tau molecules. Our model reproduces experimental observations and predicts significant effects of tau on bound time and run length which suggest an important role of tau in regulation of kinesin-based transport.
format article
author Sparacino, Javier
Farías, María Gimena
Lamberti, Pedro Walter
author_facet Sparacino, Javier
Farías, María Gimena
Lamberti, Pedro Walter
author_sort Sparacino, Javier
title Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A
title_short Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A
title_full Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A
title_fullStr Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A
title_full_unstemmed Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A
title_sort effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins kif1a
publishDate 2021
url http://hdl.handle.net/11086/19280
https://doi.org/10.1103/PhysRevE.89.022714
work_keys_str_mv AT sparacinojavier effectofthemicrotubuleassociatedproteintauondynamicsofsingleheadedmotorproteinskif1a
AT fariasmariagimena effectofthemicrotubuleassociatedproteintauondynamicsofsingleheadedmotorproteinskif1a
AT lambertipedrowalter effectofthemicrotubuleassociatedproteintauondynamicsofsingleheadedmotorproteinskif1a
bdutipo_str Repositorios
_version_ 1764820391844380673

Ejemplares similares