Renoproctective effect of hight periprocedural doses of oral N- ACETYLCYSTEINE in patients scheduled to undergo a same - day angiography
BACKGROUND: Few studies that have assessed the effect of abbrcviated oral Nacctylcysteine (NAC) rcgimens in radiocontrast-induced nephropat hy (RCIN)yield mixed results. OBJECTJVE: To evaluate the rcnoprotective effect of high periprocedural oral doses (HPOD) of NAC in patients with chronic renal im...
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Formato: | Artículo revista |
Lenguaje: | Español |
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2004
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Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/33031 |
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institution |
Universidad Nacional de Córdoba |
institution_str |
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repository_str |
R-10 |
container_title_str |
Revistas de la UNC |
language |
Español |
format |
Artículo revista |
topic |
N-acetylcysteine contrast media angiography acute renal failure N- acetilcisteina Medio de contraste Angiografía Insuficiencia renal aguda |
spellingShingle |
N-acetylcysteine contrast media angiography acute renal failure N- acetilcisteina Medio de contraste Angiografía Insuficiencia renal aguda Baderramo, Domingo Badra Verdu, Mariano Ramacciotti , Constanza Cremona, Luis Lemos, Pablo Orías, Marcelo Moreyra Jr, Eduardo Renoproctective effect of hight periprocedural doses of oral N- ACETYLCYSTEINE in patients scheduled to undergo a same - day angiography |
topic_facet |
N-acetylcysteine contrast media angiography acute renal failure N- acetilcisteina Medio de contraste Angiografía Insuficiencia renal aguda |
author |
Baderramo, Domingo Badra Verdu, Mariano Ramacciotti , Constanza Cremona, Luis Lemos, Pablo Orías, Marcelo Moreyra Jr, Eduardo |
author_facet |
Baderramo, Domingo Badra Verdu, Mariano Ramacciotti , Constanza Cremona, Luis Lemos, Pablo Orías, Marcelo Moreyra Jr, Eduardo |
author_sort |
Baderramo, Domingo |
title |
Renoproctective effect of hight periprocedural doses of oral N- ACETYLCYSTEINE in patients scheduled to undergo a same - day angiography |
title_short |
Renoproctective effect of hight periprocedural doses of oral N- ACETYLCYSTEINE in patients scheduled to undergo a same - day angiography |
title_full |
Renoproctective effect of hight periprocedural doses of oral N- ACETYLCYSTEINE in patients scheduled to undergo a same - day angiography |
title_fullStr |
Renoproctective effect of hight periprocedural doses of oral N- ACETYLCYSTEINE in patients scheduled to undergo a same - day angiography |
title_full_unstemmed |
Renoproctective effect of hight periprocedural doses of oral N- ACETYLCYSTEINE in patients scheduled to undergo a same - day angiography |
title_sort |
renoproctective effect of hight periprocedural doses of oral n- acetylcysteine in patients scheduled to undergo a same - day angiography |
description |
BACKGROUND: Few studies that have assessed the effect of abbrcviated oral Nacctylcysteine (NAC) rcgimens in radiocontrast-induced nephropat hy (RCIN)yield mixed results. OBJECTJVE: To evaluate the rcnoprotective effect of high periprocedural oral doses (HPOD) of NAC in patients with chronic renal impairmcnt undergoing a same-day angiography. METHODS: Sixty one paticnts vi1Ii renal impaired function scheduled to undcrgo a same-day angiography were randomly assigned to NAC 1200 ing orally 3 hours before and 3 after the procedure, or a placebo. Al! patients received 0.9% salme intravenous. RCIN was defined as an increase in SCC > 0.5 mg/dl 48 hours after the procedure. RESULTS: The mean baseline SCC for all patients was 1.44 ± 0.42 mg/dl. A slgnificant difference in SCC change at 48 hours after the angiography was found (-0.07 mg/dl NAC, 0.09 mg/dl placebo, P=0.04). RCIN occurred in 1 (3%)patient of NAC group and in 2 (7.1%) patients of placebo group (P=0.59). Adverse effects were similar in both groups. CONCLUSIONS: In patients withmild renal impairment patients undergoing angiographic procedures. HPOD of NAC were more effective than placebo in preventing SCC change 48 hours. A non slgnlficant benefit in RCIN incidence vas found. |
publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
publishDate |
2004 |
url |
https://revistas.unc.edu.ar/index.php/med/article/view/33031 |
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