Hemophagocytic lymphohistiocytosis as a presentation of T-cell lymphoma: Case report: Hemophagocytic lymphohistiocytosis

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Introduction: Hemophagocytic lymphohistiocytosis (HHL), a severe hyperinﬂammatory syndrome caused by aberrant activation of macrophages and cytotoxic T cells, is clinically manifested as a febrile onset along with cytopenias, high ferritin serum level and splenomegaly. In adult patients, secondary c...

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Autores principales:	Casares Diaz, Silvina Ayelén, Milanesio, Martín, Amelia, Enzo Marcelo, Saad, Emanuel José, Guanchiale, Luciana, Alomar, Juan Manuel
Formato:	Artículo revista
Lenguaje:	Español
Publicado:	Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021
Materias:	lymphohistiocytosis, hemophagocytic lymphoma immunocompromised host lymphadenopathy linfohistiocitosis hemofagocítica linfoma huésped inmunocomprometido linfadenopatía linfo-histiocitose hemofagocítica hospedeiro imunocomprometido linfadenopatia
Acceso en línea:	https://revistas.unc.edu.ar/index.php/med/article/view/30373
Aporte de:	Revistas de la UNC de Universidad Nacional de Córdoba

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language	Español
format	Artículo revista
topic	lymphohistiocytosis, hemophagocytic lymphoma immunocompromised host lymphadenopathy linfohistiocitosis hemofagocítica linfoma huésped inmunocomprometido linfadenopatía linfo-histiocitose hemofagocítica linfoma hospedeiro imunocomprometido linfadenopatia
spellingShingle	lymphohistiocytosis, hemophagocytic lymphoma immunocompromised host lymphadenopathy linfohistiocitosis hemofagocítica linfoma huésped inmunocomprometido linfadenopatía linfo-histiocitose hemofagocítica linfoma hospedeiro imunocomprometido linfadenopatia Casares Diaz, Silvina Ayelén Milanesio, Martín Amelia, Enzo Marcelo Saad, Emanuel José Guanchiale, Luciana Alomar, Juan Manuel Hemophagocytic lymphohistiocytosis as a presentation of T-cell lymphoma: Case report: Hemophagocytic lymphohistiocytosis
topic_facet	lymphohistiocytosis, hemophagocytic lymphoma immunocompromised host lymphadenopathy linfohistiocitosis hemofagocítica linfoma huésped inmunocomprometido linfadenopatía linfo-histiocitose hemofagocítica linfoma hospedeiro imunocomprometido linfadenopatia
author	Casares Diaz, Silvina Ayelén Milanesio, Martín Amelia, Enzo Marcelo Saad, Emanuel José Guanchiale, Luciana Alomar, Juan Manuel
author_facet	Casares Diaz, Silvina Ayelén Milanesio, Martín Amelia, Enzo Marcelo Saad, Emanuel José Guanchiale, Luciana Alomar, Juan Manuel
author_sort	Casares Diaz, Silvina Ayelén
title	Hemophagocytic lymphohistiocytosis as a presentation of T-cell lymphoma: Case report: Hemophagocytic lymphohistiocytosis
title_short	Hemophagocytic lymphohistiocytosis as a presentation of T-cell lymphoma: Case report: Hemophagocytic lymphohistiocytosis
title_full	Hemophagocytic lymphohistiocytosis as a presentation of T-cell lymphoma: Case report: Hemophagocytic lymphohistiocytosis
title_fullStr	Hemophagocytic lymphohistiocytosis as a presentation of T-cell lymphoma: Case report: Hemophagocytic lymphohistiocytosis
title_full_unstemmed	Hemophagocytic lymphohistiocytosis as a presentation of T-cell lymphoma: Case report: Hemophagocytic lymphohistiocytosis
title_sort	hemophagocytic lymphohistiocytosis as a presentation of t-cell lymphoma: case report: hemophagocytic lymphohistiocytosis
description	Introduction: Hemophagocytic lymphohistiocytosis (HHL), a severe hyperinﬂammatory syndrome caused by aberrant activation of macrophages and cytotoxic T cells, is clinically manifested as a febrile onset along with cytopenias, high ferritin serum level and splenomegaly. In adult patients, secondary causes of it should be looked for, such as autoimmune and infectious diseases and neoplasms. Prompt initiation of treatment is important due to the high mortality of this syndrome. Methods: A case of a 53-year-old patient diagnosed with HHL associated with T-cell lymphoma is presented as a sudden onset of several symptoms and signs of HHL, along with infectious complications. Results: Once the diagnosis of HHL was made, treatment with Etoposide and Dexamethasone was started, and with the diagnosis of T-cell lymphoma established, chemotherapy treatment with a CHOEP scheme was started, with a favorable initial evolution. Main conclusion: As HHL is a rare entity associated with high mortality, initial suspicion must be high when facing an acute onset of fever, cytopenia and splenomegaly. Nonetheless, diagnosing HHL is challenging and often appear superimposed on multiple infectious diseases. The early initiation of treatment is important given the high mortality of this pathology Key words: lymphohistiocytosis, hemophagocytic; lymphoma; immunocompromised host; lymphadenopathy
publisher	Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate	2021
url	https://revistas.unc.edu.ar/index.php/med/article/view/30373
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Hemophagocytic lymphohistiocytosis as a presentation of T-cell lymphoma: Case report: Hemophagocytic lymphohistiocytosis

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