Undifferentiated high grade pleomorphic sarcoma/ malignant fibrous histiocytoma associated a gouty tophus. a case report

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Background: Gout is a metabolic disease by deposition of uric acid crystals, which undertakes joint and soft tissue in both acute and chronic stages. Is a rare event the onset of a tumor in the site of the lesion.Objective: To present a rare case of association between sarcoma and tophi.Methods: 83...

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Autores principales: Szlabi, Susana, Flores, Jorge O., L. de Diller, Ana, Cabrera, Marta B.
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2012
Materias:
gouty tophus
malignant fibrous histiocytoma
undifferentiated high grade pleomorphic sarcoma
tofo gotoso
fibrohistiocitoma maligno
arcoma pleomórfico indiferenciado
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/20886
Aporte de:
Revistas de la UNC de Universidad Nacional de Córdoba
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institution Universidad Nacional de Córdoba
institution_str I-10
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container_title_str Revistas de la UNC
language Español
format Artículo revista
topic gouty tophus
malignant fibrous histiocytoma
undifferentiated high grade pleomorphic sarcoma
tofo gotoso
fibrohistiocitoma maligno
arcoma pleomórfico indiferenciado
spellingShingle gouty tophus
malignant fibrous histiocytoma
undifferentiated high grade pleomorphic sarcoma
tofo gotoso
fibrohistiocitoma maligno
arcoma pleomórfico indiferenciado
Szlabi, Susana
Flores, Jorge O.
L. de Diller, Ana
Cabrera, Marta B.
Undifferentiated high grade pleomorphic sarcoma/ malignant fibrous histiocytoma associated a gouty tophus. a case report
topic_facet gouty tophus
malignant fibrous histiocytoma
undifferentiated high grade pleomorphic sarcoma
tofo gotoso
fibrohistiocitoma maligno
arcoma pleomórfico indiferenciado
author Szlabi, Susana
Flores, Jorge O.
L. de Diller, Ana
Cabrera, Marta B.
author_facet Szlabi, Susana
Flores, Jorge O.
L. de Diller, Ana
Cabrera, Marta B.
author_sort Szlabi, Susana
title Undifferentiated high grade pleomorphic sarcoma/ malignant fibrous histiocytoma associated a gouty tophus. a case report
title_short Undifferentiated high grade pleomorphic sarcoma/ malignant fibrous histiocytoma associated a gouty tophus. a case report
title_full Undifferentiated high grade pleomorphic sarcoma/ malignant fibrous histiocytoma associated a gouty tophus. a case report
title_fullStr Undifferentiated high grade pleomorphic sarcoma/ malignant fibrous histiocytoma associated a gouty tophus. a case report
title_full_unstemmed Undifferentiated high grade pleomorphic sarcoma/ malignant fibrous histiocytoma associated a gouty tophus. a case report
title_sort undifferentiated high grade pleomorphic sarcoma/ malignant fibrous histiocytoma associated a gouty tophus. a case report
description Background: Gout is a metabolic disease by deposition of uric acid crystals, which undertakes joint and soft tissue in both acute and chronic stages. Is a rare event the onset of a tumor in the site of the lesion.Objective: To present a rare case of association between sarcoma and tophi.Methods: 83 year old man who consulted for tumor in his left elbow about 40 years of evolution, which spontaneously started to hurt. With the presumptive diagnosis of tophi treated surgically. The lesion recurred after 60 days, reintervention and radiotherapy was performed for diagnosis of malignant mesenchymal tumor associated with tophi. At 10 months developed ipsilateral nodal metastases, died within 2 years of the initial consultation.Results: The diagnosis of the first material resected was tophi. In the reintervention material was diagnosed mesenchymal spindle cell high grade neoplasm associated with tophi; immunohistochemistry revealed: vimentin + / +, MYO D1 - / - ASMA - / -, FVIII - / -, A1ATT - / -, CD68-/ -, S100-/ - with final diagnosis the undifferentiated high grade pleomorphic sarcoma.Conclusions: It is uncommon for gouty tophi are associated with other diseases and even fewer do so to tumors. In the literature have reported three previous cases concurrent with neoplasms, which were angiosarcoma, giant cell tumor and malignant fibrous histiocytoma. The latter have a high tendency to recur locally and have ability to distant metastases, especially lung and regional lymph nodes.
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2012
url https://revistas.unc.edu.ar/index.php/med/article/view/20886
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