Magnetic resonance as initial screening diagnosis of secondary involvement of central nervous system in NHL diffuse large B cell lymphoma

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Background: Central Nervous System (CNS) relapse in Diffuse Large B-cell Lymphoma occurs mostly 6-8 months after disease onset. This has led to propose that CNS infiltration is an early event in the evolution of the disease. We intend to evaluate the role of magnetic resonance imaging (MR) at diagno...

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Autores principales: Oliver, Ana Carolina, Irigoin, Victoria, Sgarbi, Nicolas, Peixoto, Adriana, Turcatti, Paola, Diaz, Lilian, Zunino, Juan
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2018
Materias:
magnetic resonace
diffuse large B cell lymphoma
central nervous system
resonancia magnética
linfoma difuso de grandes células B
sistema nervioso central
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/17517
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Revistas de la UNC de Universidad Nacional de Córdoba
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institution Universidad Nacional de Córdoba
institution_str I-10
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container_title_str Revistas de la UNC
language Español
format Artículo revista
topic magnetic resonace
diffuse large B cell lymphoma
central nervous system
resonancia magnética
linfoma difuso de grandes células B
sistema nervioso central
spellingShingle magnetic resonace
diffuse large B cell lymphoma
central nervous system
resonancia magnética
linfoma difuso de grandes células B
sistema nervioso central
Oliver, Ana Carolina
Irigoin, Victoria
Sgarbi, Nicolas
Peixoto, Adriana
Turcatti, Paola
Diaz, Lilian
Zunino, Juan
Magnetic resonance as initial screening diagnosis of secondary involvement of central nervous system in NHL diffuse large B cell lymphoma
topic_facet magnetic resonace
diffuse large B cell lymphoma
central nervous system
resonancia magnética
linfoma difuso de grandes células B
sistema nervioso central
author Oliver, Ana Carolina
Irigoin, Victoria
Sgarbi, Nicolas
Peixoto, Adriana
Turcatti, Paola
Diaz, Lilian
Zunino, Juan
author_facet Oliver, Ana Carolina
Irigoin, Victoria
Sgarbi, Nicolas
Peixoto, Adriana
Turcatti, Paola
Diaz, Lilian
Zunino, Juan
author_sort Oliver, Ana Carolina
title Magnetic resonance as initial screening diagnosis of secondary involvement of central nervous system in NHL diffuse large B cell lymphoma
title_short Magnetic resonance as initial screening diagnosis of secondary involvement of central nervous system in NHL diffuse large B cell lymphoma
title_full Magnetic resonance as initial screening diagnosis of secondary involvement of central nervous system in NHL diffuse large B cell lymphoma
title_fullStr Magnetic resonance as initial screening diagnosis of secondary involvement of central nervous system in NHL diffuse large B cell lymphoma
title_full_unstemmed Magnetic resonance as initial screening diagnosis of secondary involvement of central nervous system in NHL diffuse large B cell lymphoma
title_sort magnetic resonance as initial screening diagnosis of secondary involvement of central nervous system in nhl diffuse large b cell lymphoma
description Background: Central Nervous System (CNS) relapse in Diffuse Large B-cell Lymphoma occurs mostly 6-8 months after disease onset. This has led to propose that CNS infiltration is an early event in the evolution of the disease. We intend to evaluate the role of magnetic resonance imaging (MR) at diagnosis to detect early SNC compromise. Materials and Methods: Prospective longitudinal cohort’s study in DGCB patients treated at Hospital de Clínicas between 2013 and 2015. Skull MRI was performed in all patients at diagnosis and lumbar puncture was done according to predefined risk factors. Results: 35 patients were analyzed. Median age: 68 years (24-85 years). Stage III-IV: 62%, 57% good prognosis according to RIPI score and 43% poor prognosis. MRI was performed in all patients, with no pathological findings in any of them. Twenty-one patients fullfilled criteria for cerebrospinal fluid study. Twenty-two patients were studied and received intrathecal methotrexate prophylaxis. Meningeal relapse was observed in a single patient who had negative studies at diagnosis and had received complete prophylaxis at the end of the 6 R-CHOP series. Conclusions: Only one of the 35 patients relapsed in the CNS. This patient had a noral MRI and CSF study at diagnosis and had received prophylaxis with intrathecal chemotherapy. This results lead us to believe that the value of MRI to detect early infiltration in asymptomatic patients at diagnosis is low.
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2018
url https://revistas.unc.edu.ar/index.php/med/article/view/17517
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