Bioavailability of phenolic compounds and redox state of murine liver and kidney as sex-dependent responses to phytoextracts

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Background: Plant extracts can be obtained to carry bioactive compounds, useful for prevention and treatment of different illnesses. This also supports the intake of teas as functional beverages. Nonetheless, it is incompletely known whether these extracts can act as effective sources and vehicles d...

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Autores principales: Albrecht, Claudia, Guzmán, María Laura, Cittadini, María Cecilia, Canalis, Alejandra Mariel, Valentich, Mirta Ana, Olivera, María Eugenia, Soria, Elio Andrés
Formato: Artículo revista
Lenguaje:Inglés
Publicado: Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2017
Materias:
quebracho
Ilex paraguariensis
Lantana
absorción
oxidación-reducción
Quebracho
Absorption
Oxidation-Reduction
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/15412
Aporte de:
Revistas de la UNC de Universidad Nacional de Córdoba
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record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-10
container_title_str Revistas de la UNC
language Inglés
format Artículo revista
topic quebracho
Ilex paraguariensis
Lantana
absorción
oxidación-reducción
Quebracho
Ilex paraguariensis
Lantana
Absorption
Oxidation-Reduction
spellingShingle quebracho
Ilex paraguariensis
Lantana
absorción
oxidación-reducción
Quebracho
Ilex paraguariensis
Lantana
Absorption
Oxidation-Reduction
Albrecht, Claudia
Guzmán, María Laura
Cittadini, María Cecilia
Canalis, Alejandra Mariel
Valentich, Mirta Ana
Olivera, María Eugenia
Soria, Elio Andrés
Bioavailability of phenolic compounds and redox state of murine liver and kidney as sex-dependent responses to phytoextracts
topic_facet quebracho
Ilex paraguariensis
Lantana
absorción
oxidación-reducción
Quebracho
Ilex paraguariensis
Lantana
Absorption
Oxidation-Reduction
author Albrecht, Claudia
Guzmán, María Laura
Cittadini, María Cecilia
Canalis, Alejandra Mariel
Valentich, Mirta Ana
Olivera, María Eugenia
Soria, Elio Andrés
author_facet Albrecht, Claudia
Guzmán, María Laura
Cittadini, María Cecilia
Canalis, Alejandra Mariel
Valentich, Mirta Ana
Olivera, María Eugenia
Soria, Elio Andrés
author_sort Albrecht, Claudia
title Bioavailability of phenolic compounds and redox state of murine liver and kidney as sex-dependent responses to phytoextracts
title_short Bioavailability of phenolic compounds and redox state of murine liver and kidney as sex-dependent responses to phytoextracts
title_full Bioavailability of phenolic compounds and redox state of murine liver and kidney as sex-dependent responses to phytoextracts
title_fullStr Bioavailability of phenolic compounds and redox state of murine liver and kidney as sex-dependent responses to phytoextracts
title_full_unstemmed Bioavailability of phenolic compounds and redox state of murine liver and kidney as sex-dependent responses to phytoextracts
title_sort bioavailability of phenolic compounds and redox state of murine liver and kidney as sex-dependent responses to phytoextracts
description Background: Plant extracts can be obtained to carry bioactive compounds, useful for prevention and treatment of different illnesses. This also supports the intake of teas as functional beverages. Nonetheless, it is incompletely known whether these extracts can act as effective sources and vehicles de phenolic compounds (phenolics/polyphenols) to reach their targets. Objective: To establish whether phytoextract ingestion modified in a sex-dependent manner the phenolic bioavailability and redox response in liver and kidney. Method: BALB/C mice ingested for a month 100 mg/Kg/d of extracts (tea-like) from Aspidosperma quebracho-blanco (AQB), Lantana grisebachii (LG) or Ilex paraguariensis (IP). Then, phenolics, peroxides and nitrites were analyzed by spectrophotometry. Also, phenolic permeation from digested and undigested extracts was evaluated in vitro with a rat jejunum-based assay. Results: Phenolic permeation depended on extract digestion. In males, IP showed a special time course of hepatic phenolics, whereas all extracts decreased renal phenolics at 15 days. Extracts induced hepatic lipoperoxides at 15 days. LG reduced renal hydroperoxides at 15 days and hepatic nitrites at 30 days, whereas AQB and IP reduced renal lipoperoxides and nitrites at 30 days. In females, extracts reduced hydroperoxides, with LG and AQB also reducing lipoperoxides. IP increased renal lipoperoxides at 30 days. Conclusion: IP was a relevant phenolic source. Sex-dependent responses were found in all variables, which should be considered to prevent misleading generalizations in phytodrug bioprospecting.
publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2017
url https://revistas.unc.edu.ar/index.php/med/article/view/15412
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