An infrequent cause of cholestasis: morphine-induced cholestasis
Introduction: Extrahepatic cholestasis by opiates is a very rare entity of which only case reports are recorded in the literature. Methods: We present the case of a patient who developed abdominal pain and cholestasis after consumption of high doses of morphine for pain management of her underlying...
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2022
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/33738 |
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I10-R10-article-337382022-09-29T15:08:29Z An infrequent cause of cholestasis: morphine-induced cholestasis Una causa infrecuente de colestasis extrahepática: colestasis inducida por morfina Uma causa rara de colestase extra-hepática: colestase induzida por morfina Canullan, Carlos du Plessis, María Cristina Merchan del Hierro, Pablo Quesada, Bernabe Petracchi, Enrique surgery morphine cholestasis extrahepatic cholestasis General Surgery colestasis estrahepatica colestasis cirugia morfina Cirugía General morfina cirugia colestase colestase extra-hepatica Cirugia geral Introduction: Extrahepatic cholestasis by opiates is a very rare entity of which only case reports are recorded in the literature. Methods: We present the case of a patient who developed abdominal pain and cholestasis after consumption of high doses of morphine for pain management of her underlying disease, treated by laparoscopic surgery. Results: The patient evolved favorably in the postoperative period without bilirrhage and was discharged on the fifth day with bilirubin values within normal parameters. Conclusion: Sphincter of Oddi dysfunction syndrome secondary to long-term use of opioids is a very rare entity. However, it should be suspected in cases of extrahepatic cholestasis in which no stones or tumors are observed and in patients with long-term use of high-dose opiates either due to addiction or chronic pain treatment. Introducción: La colestasis extrahepática producida por opiáceos es una entidad sumamente infrecuente de la cual solo se registran reportes de casos en la literatura. Métodos: Se presenta el caso clínico de una paciente que desarrolló dolor abdominal y colestasis luego del consumo prolongado de morfina a altas dosis, tratada por cirugía laparoscópica. Resultados: La paciente evoluciona favorablemente en el postoperatorio sin bilirragia y es dada de alta al quinto día con valores de bilirrubina dentro de los parámetros normales. Conclusión: El síndrome de disfunción del esfínter de Oddi secundario a consumo por tiempo prolongado de opioides es una entidad muy infrecuente. Sin embargo, debe sospecharse ante cuadros de colestasis extrahepáticas en los que no se observe litiasis ni tumores y en pacientes con consumo de opiáceos a altas dosis por tiempo prolongado ya sea por adicción o por tratamiento del dolor crónico. Introdução: A colestase extra-hepática produzida por opiáceos é uma entidade extremamente rara, da qual apenas relatos de casos são registrados na literatura. Métodos: Apresentamos o caso clínico de uma paciente que desenvolveu dor abdominal e colestase após consumo prolongado de morfina em altas doses, tratada por cirurgia laparoscópica. Resultados: O paciente evoluiu favoravelmente no pós-operatório sem bilirragia e recebeu alta no quinto dia com valores de bilirrubina dentro dos parâmetros da normalidade. Conclusão: A síndrome da disfunção do esfíncter de Oddi secundária ao uso prolongado de opioides é uma entidade muito rara. No entanto, deve-se suspeitar em casos de colestase extra-hepática em que não são observados cálculos ou tumores e em pacientes em uso prolongado de opiáceos em altas doses, seja devido ao vício ou ao tratamento da dor crônica. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2022-09-16 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Text Texto texto application/pdf text/html https://revistas.unc.edu.ar/index.php/med/article/view/33738 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 79 No. 3 (2022); 277-279 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 79 Núm. 3 (2022); 277-279 Revista da Faculdade de Ciências Médicas de Córdoba; v. 79 n. 3 (2022); 277-279 1853-0605 0014-6722 10.31053/1853.0605.v79.n3 spa https://revistas.unc.edu.ar/index.php/med/article/view/33738/38800 https://revistas.unc.edu.ar/index.php/med/article/view/33738/38841 Derechos de autor 2022 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0 |
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Universidad Nacional de Córdoba |
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R-10 |
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Revistas de la UNC |
| language |
Español |
| format |
Artículo revista |
| topic |
surgery morphine cholestasis extrahepatic cholestasis General Surgery colestasis estrahepatica colestasis cirugia morfina Cirugía General morfina cirugia colestase colestase extra-hepatica Cirugia geral |
| spellingShingle |
surgery morphine cholestasis extrahepatic cholestasis General Surgery colestasis estrahepatica colestasis cirugia morfina Cirugía General morfina cirugia colestase colestase extra-hepatica Cirugia geral Canullan, Carlos du Plessis, María Cristina Merchan del Hierro, Pablo Quesada, Bernabe Petracchi, Enrique An infrequent cause of cholestasis: morphine-induced cholestasis |
| topic_facet |
surgery morphine cholestasis extrahepatic cholestasis General Surgery colestasis estrahepatica colestasis cirugia morfina Cirugía General morfina cirugia colestase colestase extra-hepatica Cirugia geral |
| author |
Canullan, Carlos du Plessis, María Cristina Merchan del Hierro, Pablo Quesada, Bernabe Petracchi, Enrique |
| author_facet |
Canullan, Carlos du Plessis, María Cristina Merchan del Hierro, Pablo Quesada, Bernabe Petracchi, Enrique |
| author_sort |
Canullan, Carlos |
| title |
An infrequent cause of cholestasis: morphine-induced cholestasis |
| title_short |
An infrequent cause of cholestasis: morphine-induced cholestasis |
| title_full |
An infrequent cause of cholestasis: morphine-induced cholestasis |
| title_fullStr |
An infrequent cause of cholestasis: morphine-induced cholestasis |
| title_full_unstemmed |
An infrequent cause of cholestasis: morphine-induced cholestasis |
| title_sort |
infrequent cause of cholestasis: morphine-induced cholestasis |
| description |
Introduction: Extrahepatic cholestasis by opiates is a very rare entity of which only case reports are recorded in the literature. Methods: We present the case of a patient who developed abdominal pain and cholestasis after consumption of high doses of morphine for pain management of her underlying disease, treated by laparoscopic surgery. Results: The patient evolved favorably in the postoperative period without bilirrhage and was discharged on the fifth day with bilirubin values within normal parameters. Conclusion: Sphincter of Oddi dysfunction syndrome secondary to long-term use of opioids is a very rare entity. However, it should be suspected in cases of extrahepatic cholestasis in which no stones or tumors are observed and in patients with long-term use of high-dose opiates either due to addiction or chronic pain treatment. |
| publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2022 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/33738 |
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