Determination of some oxidative stress, functional and immunological markers in the saliva of patients undergoing bone marrow transplantation (BMT).
OBJECTIVE: high doses of chemotherapy used prior to bone marrow transplantation (BMT) promote severe changes in the stomatognathic system. The objective of the present work consisted in evaluating some functional, immunological and oxidative stress markers in saliva of these patients. METHODS: a lon...
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/33227 |
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I10-R10-article-33227 |
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ojs |
| institution |
Universidad Nacional de Córdoba |
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I-10 |
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R-10 |
| container_title_str |
Revistas de la UNC |
| language |
Español |
| format |
Artículo revista |
| topic |
Bone Marrow Transplantation Saliva Biomarkers Oxidative Stress Trasplante de Médula Ósea Saliva Biomarcadores Estrés Oxidativo Transplante de Medula Óssea Saliva Biomarcadores Estresse Oxidativo |
| spellingShingle |
Bone Marrow Transplantation Saliva Biomarkers Oxidative Stress Trasplante de Médula Ósea Saliva Biomarcadores Estrés Oxidativo Transplante de Medula Óssea Saliva Biomarcadores Estresse Oxidativo Bachmeier, Evelin Migueles Goitea, María Elena Linares, Jorge Alberto Wietz, Fernando Martin Jarchum, Sol Jarchum, Gustavo Brunotto, Mabel Noemi Mazzeo, Marcelo Adrian Determination of some oxidative stress, functional and immunological markers in the saliva of patients undergoing bone marrow transplantation (BMT). |
| topic_facet |
Bone Marrow Transplantation Saliva Biomarkers Oxidative Stress Trasplante de Médula Ósea Saliva Biomarcadores Estrés Oxidativo Transplante de Medula Óssea Saliva Biomarcadores Estresse Oxidativo |
| author |
Bachmeier, Evelin Migueles Goitea, María Elena Linares, Jorge Alberto Wietz, Fernando Martin Jarchum, Sol Jarchum, Gustavo Brunotto, Mabel Noemi Mazzeo, Marcelo Adrian |
| author_facet |
Bachmeier, Evelin Migueles Goitea, María Elena Linares, Jorge Alberto Wietz, Fernando Martin Jarchum, Sol Jarchum, Gustavo Brunotto, Mabel Noemi Mazzeo, Marcelo Adrian |
| author_sort |
Bachmeier, Evelin |
| title |
Determination of some oxidative stress, functional and immunological markers in the saliva of patients undergoing bone marrow transplantation (BMT). |
| title_short |
Determination of some oxidative stress, functional and immunological markers in the saliva of patients undergoing bone marrow transplantation (BMT). |
| title_full |
Determination of some oxidative stress, functional and immunological markers in the saliva of patients undergoing bone marrow transplantation (BMT). |
| title_fullStr |
Determination of some oxidative stress, functional and immunological markers in the saliva of patients undergoing bone marrow transplantation (BMT). |
| title_full_unstemmed |
Determination of some oxidative stress, functional and immunological markers in the saliva of patients undergoing bone marrow transplantation (BMT). |
| title_sort |
determination of some oxidative stress, functional and immunological markers in the saliva of patients undergoing bone marrow transplantation (bmt). |
| description |
OBJECTIVE: high doses of chemotherapy used prior to bone marrow transplantation (BMT) promote severe changes in the stomatognathic system. The objective of the present work consisted in evaluating some functional, immunological and oxidative stress markers in saliva of these patients.
METHODS: a longitudinal observational study was carried out on 22 patients admitted to the Bone Marrow Transplant Unit of the Oncohematology Service of the Sanatorio Allende between March 2019 and February 2020. Basal saliva collection was carried out in the initial stage (I ) prior to isolation and middle stage (M) 14 days after conditioning therapy and transplantation. The concentration of uric acid (UA), superoxide dismutase (SOD), malondialdehyde (MDA), salivary alpha amylase, secretory immunoglobulin A (Ig As), lactoferrin, ceruloplasmin and urea were analyzed.
RESULTS: in (M) the levels of SOD and MAD increased significantly compared to (I) (p <0.01). The concentration of salivary alpha amylase, Ig As, lactoferrin and uric acid was significantly lower in (M) compared to (I ) p <0.0001, p <0.01, p <0.0001, p <0.02 respectively. Ceruloplasmin and Urea did not show variations during treatment.
CONSLUSION: in the present study, a decrease in the defensive capacity of saliva was observed as a consequence of a reduction in the concentration of Ig As and lactoferrin. The increase in SOD in (M) could be interpreted as a defense mechanism of saliva against oxidative stress produced by chemotherapy. The decrease in uric acid in stage (M) could allow the worsening of mucositis. The synthesis and release of amylase was affected by treatment with cytostatic drugs. |
| publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/33227 |
| work_keys_str_mv |
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2022-08-20T01:27:53Z |
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2022-08-20T01:27:53Z |
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I10-R10-article-332272021-12-29T20:14:46Z Determination of some oxidative stress, functional and immunological markers in the saliva of patients undergoing bone marrow transplantation (BMT). Determinación de algunos marcadores de estrés oxidativo, funcionales e inmunológicos en saliva de pacientes sometidos a trasplante de médula ósea (TMO). Determinação de algunos marcadores de estrés oxidativo, funcionales e inmunológicos na saliva de pacientes em algum lugar a trasplante de médula ósea (TMO). Bachmeier, Evelin Migueles Goitea, María Elena Linares, Jorge Alberto Wietz, Fernando Martin Jarchum, Sol Jarchum, Gustavo Brunotto, Mabel Noemi Mazzeo, Marcelo Adrian Bone Marrow Transplantation Saliva Biomarkers Oxidative Stress Trasplante de Médula Ósea Saliva Biomarcadores Estrés Oxidativo Transplante de Medula Óssea Saliva Biomarcadores Estresse Oxidativo OBJECTIVE: high doses of chemotherapy used prior to bone marrow transplantation (BMT) promote severe changes in the stomatognathic system. The objective of the present work consisted in evaluating some functional, immunological and oxidative stress markers in saliva of these patients. METHODS: a longitudinal observational study was carried out on 22 patients admitted to the Bone Marrow Transplant Unit of the Oncohematology Service of the Sanatorio Allende between March 2019 and February 2020. Basal saliva collection was carried out in the initial stage (I ) prior to isolation and middle stage (M) 14 days after conditioning therapy and transplantation. The concentration of uric acid (UA), superoxide dismutase (SOD), malondialdehyde (MDA), salivary alpha amylase, secretory immunoglobulin A (Ig As), lactoferrin, ceruloplasmin and urea were analyzed. RESULTS: in (M) the levels of SOD and MAD increased significantly compared to (I) (p <0.01). The concentration of salivary alpha amylase, Ig As, lactoferrin and uric acid was significantly lower in (M) compared to (I ) p <0.0001, p <0.01, p <0.0001, p <0.02 respectively. Ceruloplasmin and Urea did not show variations during treatment. CONSLUSION: in the present study, a decrease in the defensive capacity of saliva was observed as a consequence of a reduction in the concentration of Ig As and lactoferrin. The increase in SOD in (M) could be interpreted as a defense mechanism of saliva against oxidative stress produced by chemotherapy. The decrease in uric acid in stage (M) could allow the worsening of mucositis. The synthesis and release of amylase was affected by treatment with cytostatic drugs. OBJETIVO: altas dosis de quimioterapia utilizadas previo al trasplante de médula ósea (TMO) pueden promover severos cambios en el sistema estomatognático. El objetivo consistió en evaluar algunos marcadores funcionales, inmunológicos y de estrés oxidativo en saliva de pacientes sometidos a dicho tratamiento. MÉTODOS: estudio observacional longitudinal en 22 pacientes de la Unidad de trasplante de Médula Ósea del Servicio de Oncohematología del Sanatorio Allende. Se efectuó recolección de saliva basal en etapa inicial (I) previa al aislamiento y etapa media (M) 14 días posteriores a la terapia de acondicionamiento y trasplante. Se analizó la concentración de ácido úrico (AU), superóxido dismutasa (SOD), malondialdehido (MDA), alfa amilasa salival, inmunoglobulina A secretora (Ig As), lactoferrina, ceruloplasmina y urea. RESULTADOS: en (M) los niveles de SOD y MAD aumentaron significativamente respecto de (I) (p< 0.01). La concentración de alfa amilasa salival, Ig As, lactoferrina y ácido úrico fue significativamente menor en (M) respecto de ( I ) p < 0.0001, p < 0.01, p < 0.0001, p <0.02 respectivamente. Ceruloplasmina y Urea no mostraron variaciones. CONCLUSIÓN: se observó una disminución de la capacidad defensiva de la saliva como consecuencia de una reducción de la concentración de Ig As y lactoferrina. El incremento de SOD en (M) podría interpretarse como un mecanismo de defensa de la saliva contra el estrés oxidativo producido por la quimioterapia. La disminución de ácido úrico en la etapa (M) podría favorecer el agravamiento de mucositis. La síntesis y liberación de amilasa fue afectada por el tratamiento con citostáticos. OBJETIVO: Altas doses de quimioterapia utilizadas antes do transplante de medula óssea (TMO) podem promover alterações graves no sistema estomatognático. O objetivo do presente trabalho consiste em avaliar algunos marcadores funcionais, imunológicos e de estrés oxidativos na saliva de pacientes em algum tipo de tratamento. MÉTODOS: se efetuou um estúdio observacional longitudinal em 22 pacientes que incorporaram ao isolamento da Unidade de Transplante de Médula Ósea do Serviço de Oncohematologia do Sanatório Allende entre março de 2019 e fevereiro de 2020. Se efetuou a recuperação da saliva basal na fase inicial (I ) Aislamiento anterior y etapa media (M) 14 días posteriores a la terapia de acondicionamiento y trasplante. Analise a concentração de ácido úrico (AU), superóxido dismutasa (SOD), malondialdehido (MDA), alfa amilasa salival, imunoglobulina A secretora (Ig As), lactoferrina, ceruloplasmina e ureia. RESULTADOS: en (M) los niveles de SOD e MAD aumentaron completar o respecto de (I) (p <0,01). La concentración de alfa amilasa salival, Ig As, lactoferrina y ácido úrico fue complete menor en (M) respecto de (I) p <0,0001, p <0,01, p <0,0001, p <0,02 respectivamente. Ceruloplasmina y Urea no mostraron variaciones durante o tratamiento. CONCLUSÃO: no presente trabalho se observa uma redução da capacidade defensiva da saliva como consequência de uma redução da concentração de Ig As e lactoferrina. O incremento de SOD en (M) pode ser interpretado como um mecanismo de defesa da saliva contra o estrés oxidativo produzido pela quimioterapia. A eliminação de ácido úrico na etapa (M) pode favorecer o agravamento da mucosite. La síntesis y liberación de amilasa fue afectada por el tratamiento con citostáticos. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-12-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion text texto texto application/pdf text/html https://revistas.unc.edu.ar/index.php/med/article/view/33227 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. 4 (2021); 384-390 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. 4 (2021); 384-390 Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. 4 (2021); 384-390 1853-0605 0014-6722 10.31053/1853.0605.v78.n4 spa https://revistas.unc.edu.ar/index.php/med/article/view/33227/36608 https://revistas.unc.edu.ar/index.php/med/article/view/33227/36613 Derechos de autor 2021 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0 |