Long-term results in patients with lung resections for colorectal cancer metastases. Experience of a single center in Argentina
Introduction: Between 5-10% of patients who undergo curative surgery for colorectal cancer (CRC) will present recurrence of their disease on the lungs. Surgical treatment of pulmonary metastases (PM) has gained popularity over the years, different publications report an overall survival rate at 5 ye...
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Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2022
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/32403 |
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I10-R10-article-32403 |
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Universidad Nacional de Córdoba |
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I-10 |
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Revistas de la UNC |
| language |
Español |
| format |
Artículo revista |
| topic |
neoplasm metastasis pulmonary surgical procedures colorectal surgery metástasis de la neoplasia procedimientos quirúrgicos pulmonares cirugía colorrectal metástase neoplásica procedimentos cirúrgicos pulmonares cirurgia colorretal |
| spellingShingle |
neoplasm metastasis pulmonary surgical procedures colorectal surgery metástasis de la neoplasia procedimientos quirúrgicos pulmonares cirugía colorrectal metástase neoplásica procedimentos cirúrgicos pulmonares cirurgia colorretal Olivera Lopez, Soledad Belen Raices, Micaela Basbus, Luis Cerini, Matias Minatta, Nicolas Dietrich, Agustin Smith, David Long-term results in patients with lung resections for colorectal cancer metastases. Experience of a single center in Argentina |
| topic_facet |
neoplasm metastasis pulmonary surgical procedures colorectal surgery metástasis de la neoplasia procedimientos quirúrgicos pulmonares cirugía colorrectal metástase neoplásica procedimentos cirúrgicos pulmonares cirurgia colorretal |
| author |
Olivera Lopez, Soledad Belen Raices, Micaela Basbus, Luis Cerini, Matias Minatta, Nicolas Dietrich, Agustin Smith, David |
| author_facet |
Olivera Lopez, Soledad Belen Raices, Micaela Basbus, Luis Cerini, Matias Minatta, Nicolas Dietrich, Agustin Smith, David |
| author_sort |
Olivera Lopez, Soledad Belen |
| title |
Long-term results in patients with lung resections for colorectal cancer metastases. Experience of a single center in Argentina |
| title_short |
Long-term results in patients with lung resections for colorectal cancer metastases. Experience of a single center in Argentina |
| title_full |
Long-term results in patients with lung resections for colorectal cancer metastases. Experience of a single center in Argentina |
| title_fullStr |
Long-term results in patients with lung resections for colorectal cancer metastases. Experience of a single center in Argentina |
| title_full_unstemmed |
Long-term results in patients with lung resections for colorectal cancer metastases. Experience of a single center in Argentina |
| title_sort |
long-term results in patients with lung resections for colorectal cancer metastases. experience of a single center in argentina |
| description |
Introduction: Between 5-10% of patients who undergo curative surgery for colorectal cancer (CRC) will present recurrence of their disease on the lungs. Surgical treatment of pulmonary metastases (PM) has gained popularity over the years, different publications report an overall survival rate at 5 years of between 30% and 60%. We present a review of patients with PM resections of CRC treated in a single center in Argentina.
Materials and methods: A descriptive, observational, retrospective study was conducted between 2008 and 2018. All patients with pulmonary metastasectomy of colorectal cancer were included. The primary endpoint was to evaluate overall survival and disease-free survival. Possible prognostic factors were evaluated as a secondary endpoint.
Results: A total of 99 surgeries were performed in the 68 patients, the resection was multiple in 48.5%, with more than 3 nodules in 13%. Overall and progression-free survival at 5 years was 55% and 27%, respectively. In the statistical analysis we found that the lesions in more than one lobe (p = 0.015) and the resection of more than 3 nodules (p = 0.011) presented a lower overall survival.
Conclusions: in this retrospective analysis we evidenced comparable values to the world literature regarding morbidity, mortality, overall survival and progression-free. In our series, patients with disease in more than one lobe or more than three resected lesions had significantly lower overall survival.
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| publisher |
Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2022 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/32403 |
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I10-R10-article-324032022-09-29T15:08:29Z Long-term results in patients with lung resections for colorectal cancer metastases. Experience of a single center in Argentina Resultados a largo plazo en pacientes con resecciones pulmonares por metástasis de cáncer colorrectal. Experiencia de un solo centro de Argentina Resultados a longo prazo em pacientes com ressecções pulmonares para metástases de câncer colorretal. Experiência de um único centro na Argentina Olivera Lopez, Soledad Belen Raices, Micaela Basbus, Luis Cerini, Matias Minatta, Nicolas Dietrich, Agustin Smith, David neoplasm metastasis pulmonary surgical procedures colorectal surgery metástasis de la neoplasia procedimientos quirúrgicos pulmonares cirugía colorrectal metástase neoplásica procedimentos cirúrgicos pulmonares cirurgia colorretal Introduction: Between 5-10% of patients who undergo curative surgery for colorectal cancer (CRC) will present recurrence of their disease on the lungs. Surgical treatment of pulmonary metastases (PM) has gained popularity over the years, different publications report an overall survival rate at 5 years of between 30% and 60%. We present a review of patients with PM resections of CRC treated in a single center in Argentina. Materials and methods: A descriptive, observational, retrospective study was conducted between 2008 and 2018. All patients with pulmonary metastasectomy of colorectal cancer were included. The primary endpoint was to evaluate overall survival and disease-free survival. Possible prognostic factors were evaluated as a secondary endpoint. Results: A total of 99 surgeries were performed in the 68 patients, the resection was multiple in 48.5%, with more than 3 nodules in 13%. Overall and progression-free survival at 5 years was 55% and 27%, respectively. In the statistical analysis we found that the lesions in more than one lobe (p = 0.015) and the resection of more than 3 nodules (p = 0.011) presented a lower overall survival. Conclusions: in this retrospective analysis we evidenced comparable values to the world literature regarding morbidity, mortality, overall survival and progression-free. In our series, patients with disease in more than one lobe or more than three resected lesions had significantly lower overall survival. Introducción: Entre el 5-10% de los pacientes que se someten a cirugía curativa por cáncer colorrectal (CCR) presentarán en algún momento recurrencia de su enfermedad a nivel pulmonar. El tratamiento quirúrgico de las metástasis pulmonares (MP) fue ganando popularidad a través de los años, diferentes publicaciones informan una tasa de supervivencia global a los 5 años de entre 30% a 60%. Presentamos una revisión de pacientes con resecciones por MP de CCR tratados en un único centro en Argentina. Materiales y métodos: Se realizó un estudio descriptivo, observacional, retrospectivo entre 2008 y 2018. Se incluyeron todos los pacientes con resecciones de MP de CCR. El objetivo primario fue evaluar la supervivencia global y supervivencia libre de enfermedad. Como objetivo secundario se evaluaron posibles factores pronósticos. Resultados: Se realizaron un total de 99 cirugías en los 68 pacientes, la resección fue múltiple en un 48,5%, siendo más de 3 nódulos en un 13%. La supervivencia global y libre de progresión a los 5 años fue del 55% y del 27% respectivamente. En el análisis estadístico encontramos que las lesiones en más de un lóbulo (p=0.015) y la resección de más de 3 nódulos (p=0.011) presentaron una menor supervivencia global. Conclusiones: En este análisis retrospectivo evidenciamos valores comparables a la literatura mundial con respecto a morbilidad, mortalidad, supervivencia global y libre de progresión. En nuestra serie los pacientes con enfermedad en más de un lóbulo o más de tres lesiones resecadas presentan significativamente menor supervivencia global. Introdução: Entre 5 e 10% dos pacientes submetidos à cirurgia curativa para câncer colorretal (CCR), em algum momento, terão recorrência da doença pulmonar. O tratamento cirúrgico das metástases pulmonares (PM) tem ganhado popularidade ao longo dos anos; diferentes publicações relatam uma taxa de sobrevida global em 5 anos entre 30% e 60%. Apresentamos uma revisão de pacientes com ressecções de MP de CCR tratados em um único centro na Argentina. Materiais e métodos: Um estudo descritivo, observacional e retrospectivo foi realizado entre 2008 e 2018. Todos os pacientes com ressecções de MP RCC foram incluídos. O objetivo principal foi avaliar a sobrevida global e a sobrevida livre de doença. Possíveis fatores prognósticos foram avaliados como objetivo secundário. Resultados: Um total de 99 cirurgias foram realizadas nos 68 pacientes, a ressecção foi múltipla em 48,5%, com mais de 3 nódulos em 13%. A sobrevida geral e livre de progressão em 5 anos foi de 55% e 27%, respectivamente. Na análise estatística constatamos que as lesões em mais de um lobo (p = 0,015) e a ressecção de mais de 3 nódulos (p = 0,011) apresentaram menor sobrevida global. Conclusões: Nesta análise retrospectiva, evidenciamos valores comparáveis à literatura mundial em relação à morbidade, mortalidade, sobrevida global e livre de progressão. Em nossa série, os pacientes com doença em mais de um lobo ou mais de três lesões ressecadas tiveram sobrevida global significativamente menor.. Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2022-09-16 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html https://revistas.unc.edu.ar/index.php/med/article/view/32403 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 79 No. 3 (2022); 217-222 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 79 Núm. 3 (2022); 217-222 Revista da Faculdade de Ciências Médicas de Córdoba; v. 79 n. 3 (2022); 217-222 1853-0605 0014-6722 10.31053/1853.0605.v79.n3 spa https://revistas.unc.edu.ar/index.php/med/article/view/32403/38746 https://revistas.unc.edu.ar/index.php/med/article/view/32403/38835 Derechos de autor 2022 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0 |