Systemic and intra-accumbal administration of the 5-ht1b receptor agonist CP94253 modulates oral self-administration of ethanol in rats

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It has been suggested that some addictive properties of ethanol (EtOH) are modulated by 5-HT1B receptors in the nucleus accumbens (nAcc). This research was designed to assess the effects of systemic and intra-accumbal administration of the 5-HT1B receptor agonist CP94253 on the oral self-administrat...

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Autores principales: Jiménez, Juan C., Cortés-Salazar, Felipe, Cedillo-Ildefonso, Benita, Miranda, Florencio
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional de Córdoba 2022
Materias:
5-HT1B receptors
EtOH
nAcc
self-administration
receptores 5-HT1B
auto-administración
Acceso en línea:https://revistas.unc.edu.ar/index.php/racc/article/view/30138
Aporte de:
Revistas de la UNC de Universidad Nacional de Córdoba
id I10-R10-article-30138
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spelling I10-R10-article-301382022-04-22T18:59:46Z Systemic and intra-accumbal administration of the 5-ht1b receptor agonist CP94253 modulates oral self-administration of ethanol in rats La administración sistémica e intra-accumbens del agonista 5-HT1B CP94253 modula la auto-administración oral de etanol en ratas Jiménez, Juan C. Cortés-Salazar, Felipe Cedillo-Ildefonso, Benita Miranda, Florencio 5-HT1B receptors EtOH nAcc self-administration receptores 5-HT1B EtOH nAcc auto-administración It has been suggested that some addictive properties of ethanol (EtOH) are modulated by 5-HT1B receptors in the nucleus accumbens (nAcc). This research was designed to assess the effects of systemic and intra-accumbal administration of the 5-HT1B receptor agonist CP94253 on the oral self-administration of EtOH in rats. Male Wistar rats were water deprived for 24 h, and then trained to lever-press for EtOH reinforcement on a FR3 schedule until response rate remained stable at 80%. After this training, a group of rats received an intraperitoneal injection of 5-HT1B receptor agonist CP94253 before rats were under FR3 schedule of reinforcement for EtOH access. Another group of rats, after similar training, received intra-accumbal injection of CP94253. The data showed that both systemic and intra-accumbal injections reduced oral self-administration of EtOH. These findings suggest that the 5-HT1B receptors activation may modulate the reduction of oral self-administration of EtOH in rats. moduladas por receptores 5-HT1B en el núcleo accumbens (nAcc). Esta investigación se diseñó para evaluar los efectos de la administración sistémica e intra-accumbens del agonista 5-HT1B CP94253 en la auto-administración oral de EtOH. Se utilizaron ratas machos Wistar que se privaron de agua por 24 h, y se entrenaron a presionar una palanca para obtener EtOH como reforzador hasta que la tasa de respuestas permaneció estable al 80%. Después, a un grupo de ratas se les administró una inyección intraperitoneal del agonista 5-HT1B CP94253 antes de someterse al programa RF3 (razón fija 3) con EtOH como reforzador. Otro grupo de ratas, después de un entrenamiento similar, se les administró una inyección intra-accumbens de CP94253. Los datos indicaron que tanto la inyección sistémica como la intra-accumbens de CP94253 redujeron la auto-administración oral de EtOH. Esto sugiere que los receptores 5-HT1B podrían participar en la modulación de la auto-administración oral de EtOH. Universidad Nacional de Córdoba 2022-04-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/racc/article/view/30138 Argentinean Journal of Behavioral Sciences; Vol. 14 No. 1 (2022): REVISTA ARGENTINA DE CIENCIAS DEL COMPORTAMIENTO; 68-81 Revista Argentina de Ciencias del Comportamiento; Vol. 14 Núm. 1 (2022): REVISTA ARGENTINA DE CIENCIAS DEL COMPORTAMIENTO; 68-81 1852-4206 10.32348/1852.4206.v14.n1 spa https://revistas.unc.edu.ar/index.php/racc/article/view/30138/37569 Derechos de autor 2022 Juan C. Jiménez, Felipe Cortés-Salazar, Benita Cedillo-Ildefonso, Florencio Miranda http://creativecommons.org/licenses/by/4.0
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-10
container_title_str Revistas de la UNC
language Español
format Artículo revista
topic 5-HT1B receptors
EtOH
nAcc
self-administration
receptores 5-HT1B
EtOH
nAcc
auto-administración
spellingShingle 5-HT1B receptors
EtOH
nAcc
self-administration
receptores 5-HT1B
EtOH
nAcc
auto-administración
Jiménez, Juan C.
Cortés-Salazar, Felipe
Cedillo-Ildefonso, Benita
Miranda, Florencio
Systemic and intra-accumbal administration of the 5-ht1b receptor agonist CP94253 modulates oral self-administration of ethanol in rats
topic_facet 5-HT1B receptors
EtOH
nAcc
self-administration
receptores 5-HT1B
EtOH
nAcc
auto-administración
author Jiménez, Juan C.
Cortés-Salazar, Felipe
Cedillo-Ildefonso, Benita
Miranda, Florencio
author_facet Jiménez, Juan C.
Cortés-Salazar, Felipe
Cedillo-Ildefonso, Benita
Miranda, Florencio
author_sort Jiménez, Juan C.
title Systemic and intra-accumbal administration of the 5-ht1b receptor agonist CP94253 modulates oral self-administration of ethanol in rats
title_short Systemic and intra-accumbal administration of the 5-ht1b receptor agonist CP94253 modulates oral self-administration of ethanol in rats
title_full Systemic and intra-accumbal administration of the 5-ht1b receptor agonist CP94253 modulates oral self-administration of ethanol in rats
title_fullStr Systemic and intra-accumbal administration of the 5-ht1b receptor agonist CP94253 modulates oral self-administration of ethanol in rats
title_full_unstemmed Systemic and intra-accumbal administration of the 5-ht1b receptor agonist CP94253 modulates oral self-administration of ethanol in rats
title_sort systemic and intra-accumbal administration of the 5-ht1b receptor agonist cp94253 modulates oral self-administration of ethanol in rats
description It has been suggested that some addictive properties of ethanol (EtOH) are modulated by 5-HT1B receptors in the nucleus accumbens (nAcc). This research was designed to assess the effects of systemic and intra-accumbal administration of the 5-HT1B receptor agonist CP94253 on the oral self-administration of EtOH in rats. Male Wistar rats were water deprived for 24 h, and then trained to lever-press for EtOH reinforcement on a FR3 schedule until response rate remained stable at 80%. After this training, a group of rats received an intraperitoneal injection of 5-HT1B receptor agonist CP94253 before rats were under FR3 schedule of reinforcement for EtOH access. Another group of rats, after similar training, received intra-accumbal injection of CP94253. The data showed that both systemic and intra-accumbal injections reduced oral self-administration of EtOH. These findings suggest that the 5-HT1B receptors activation may modulate the reduction of oral self-administration of EtOH in rats.
publisher Universidad Nacional de Córdoba
publishDate 2022
url https://revistas.unc.edu.ar/index.php/racc/article/view/30138
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first_indexed 2022-08-20T00:49:59Z
last_indexed 2022-08-20T00:49:59Z
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